ArticleLipids in health and disease2024
The predictive value of the hs-CRP/HDL-C ratio, an inflammation-lipid composite marker, for cardiovascular disease in middle-aged and elderly people: evidence from a large national cohort study.
Article in Lipids in health and disease, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 74 papers, 1 of them a synthesis that pooled it.
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Who cites it
74 citing papers in PubMed, 1 synthesis or guideline pooled it, 72 citations in OpenAlex.
- Hs-CRP as a biomarker for atherosclerosis progression and cardiovascular risk: a systematic review.PeerJ · 2026Pooled it
- Repurposing doxycycline as an adjunct to sitagliptin in type 2 diabetes mellitus: a randomized controlled study on glycemic, inflammatory, and cardiometabolic outcomes.Naunyn-Schmiedeberg's archives of pharmacology · 2026Trial
- Trial
- Omega-3 fatty acids effectively mitigate high-sensitivity C-reactive protein (hs-CRP) biomarker of inflammation in acute myocardial infarction patients: a randomized, double-blind, placebo-controlled clinical trial.Naunyn-Schmiedeberg's archives of pharmacology · 2025Trial
- The association of long-term air pollution with a composite neurodegenerative risk score among Chinese elderly: evidence from the CHARLS.Environmental health : a global access science source · 2026Article
- Screening for Suspected Microplastic-like Particles in Post-Mortem Human Liver: Correlating Histopathological Alterations with Clinical Profiles.Life (Basel, Switzerland) · 2026Article
- Association of high-sensitivity C-reactive protein-to-hemoglobin ratio with stroke risk: A study based on the China Health and Retirement Longitudinal Study and English Longitudinal Study of Ageing cohorts.The Journal of international medical research · 2026Article
- hs-CRP/HDL Ratio Across Obesity and Type 2 Diabetes Mellitus Phenotypes in Adults: A Cross-Sectional Study.Diagnostics (Basel, Switzerland) · 2026Article
- Combined impact of inflammation score and depression on clinical outcomes in patients after percutaneous coronary intervention: a retrospective cohort study.BMC cardiovascular disorders · 2026Article
- Uric acid to high-density lipoprotein cholesterol ratio as a novel biomarker for sarcopenia: a national study with machine learning insights.The journals of gerontology. Series A, Biological sciences and medical sciences · 2026Article
- Association between remnant cholesterol inflammation index and erectile dysfunction among U.S. adults: a cross-sectional study.Translational andrology and urology · 2026Article
- Changes in Immune-Inflammation Status and Acute Ischemic Stroke Prognosis in Prospective Cohort.Annals of clinical and translational neurology · 2026Article
- Cumulative inflammatory index and the risk of cardiometabolic multimorbidity: a prospective cohort study among middle-aged and older adults in China.Journal of health, population, and nutrition · 2026Article
- Associations of the hs-CRP/HDL-C ratio with cardiovascular metabolic multimorbidity: a large cross-sectional study.Scientific reports · 2026Article
- Comparative predictive value of three non-insulin-based insulin resistance indices for subclinical left ventricular dysfunction in type 2 diabetes mellitus.BMC cardiovascular disorders · 2026Article
- Identification of key cardiovascular disease predictive factors from the China Health and Retirement Longitudinal Study dataset using machine learning-based algorithms.Journal of translational medicine · 2026Article
- Association of C-reactive protein/high-density lipoprotein cholesterol ratio with stroke in Chinese adults across different glycemic status.Lipids in health and disease · 2026Article
- Beyond inflammation and cholesterol: atherogenic index of plasma mediates the link between hsCRP/HDL-C ratio and depression in US adults NHANES 2015-2020.Annals of general psychiatry · 2026Article
- Diagnostic and Prognostic Utility of DNI and CRP in Patients with Dilated Cardiomyopathy.International journal of molecular sciences · 2026Article
- A cohort study in Southern Xinjiang, China, 2018-2023 on the association of metabolic syndrome components and their interactions with cardiovascular disease risk.Frontiers in cardiovascular medicine · 2026Article
14 more citing papers are in PubMed but not listed here.
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Authors and funding
8 authors at 3 institutions in 1 country.
Funding
Abstract
BACKGROUND AND
aimsCardiovascular disease (CVD) is associated with inflammation and abnormal lipid metabolism. However, a single inflammatory index or a single lipid index cannot accurately predict the prognosis of CVD independently because it is prone to be affected by various confounding factors.
methodsThis population-based cohort study included 6,554 participants from the China Health and Retirement Longitudinal Study (CHARLS) to investigate correlations. In the present study, the occurrence of CVD events such as stroke and heart disease was evaluated by considering self-reported diagnoses at the beginning of the study and during wave 4, and a restricted cubic spline model was used to investigate potential nonlinear relationships in addition to multivariate logistic regression models. Stratified analyses were performed to examine how sociodemographic characteristics may influence the results.
resultsSeven years of follow-up (2011-2018) revealed that 786 people (11.99%) developed CVD. According to the adjusted model, the high-sensitivity C-reactive protein (hs-CRP)-to-high-density lipoprotein cholesterol (HDL-C) ratio is a contributing factor to CVD risk (OR 1.31, 95% CI 1.05-1.64). In addition, a nonlinear relationship was observed between the hs-CRP/HDL-C ratio and the occurrence of new CVD, stroke, or cardiac issues (P
conclusionsAccording to the present cohort study, a high hs-CRP/HDL-C ratio is a significant risk factor for CVD, new stroke, and heart problems. Early intervention in patients with increased hs-CRP/HDL-C ratios may further reduce the incidence of CVD, in addition to focusing on independent lipid markers or independent inflammatory markers.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.