Evidence map›Paper›PMID 38429764›Full record

ArticleEuropean journal of medical research2024

Study on the effect and mechanism of Zhenzhu Tongluo pills in treating diabetic peripheral neuropathy injury.

Pengfei Dong, Lin Zhou, Xiaohui Wang, Lianping Xue, Yang Du, Rui Cui

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in European journal of medical research, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
0.4field-weighted citation impact, top 36% of its field
1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 1 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 1 country.

Pengfei Dong *Department of Chinese Medicine, The Second Affiliated Hospital of Zhengzhou University, Zhengzhou, 450014, China.
Lin Zhou *Department of Pharmacy, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, 450052, China. fcczhoul@zzu.edu.cn.
Xiaohui WangDepartment of Ultrasound, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, 450052, China. xhhyykl@126.com.
Lianping XueDepartment of Pharmacy, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, 450052, China.
Yang DuSecond Ward of Internal Medicine, Rehabilitation Hospital of Zhengzhou Cigarette Factory, Zhengzhou, 450000, China.
Rui CuiDepartment of Ultrasonography, The Sixth Affiliated Hospital, Sun Yat-Sen University, Guangzhou, 510000, China.
First Affiliated Hospital of Zhengzhou University · CNSecond Affiliated Hospital of Zhengzhou University · CNSixth Affiliated Hospital of Sun Yat-sen University · CN

Funding

GuangDong Basic and Applied Basic Research Foundation 2021A1515110107Guangzhou Basic and Applied Basic Research Program 202102020992Key scientific research Project of colleges and universities in Henan Province 23A320050Key scientific research Project of colleges and universities in Henan Province 23A360018Medical Science and Technology Project of Henan Province (LHGJ20220496)
6 · The paper itself

Abstract

backgroundAs a traditional Mongolian medicine, Zhenzhu Tongluo pills has played a good neuroprotective function in clinic. However, the key mechanisms by which it works are poorly studied.

objectivesTo study the effect and mechanism of Zhenzhu Tongluo pills in treating diabetic peripheral neuropathy injury.

methodsDiabetic peripheral neuropathy model was established by injecting STZ into rats. Physiological, behavioral, morphological and functional analyses were used to evaluate that the overall therapeutic effect of rats, ELISA, qRT-PCR, Western blot, immunohistochemical staining, HE staining and TUNEL staining were used to further study the related mechanism.

resultsZhenzhu Tongluo pills can significantly improve the physiological changes, behavioral abnormalities, structural and functional damage in diabetic peripheral neuropathy rats, which may be related to the anti-inflammatory and anti-apoptotic effects that realized by regulating PI3K/AKT, MAPK, NF-κB signaling pathways.

conclusionsZhenzhu Tongluo pills has neuroprotective effect, and anti-inflammatory and anti-apoptosis may be the important way of its function.

Indexed as

Diabetes MellitusDiabetic NeuropathiesDrugs, Chinese HerbalAnimalsAnti-Inflammatory AgentsNF-kappa BPhosphatidylinositol 3-KinasesRatsAnti-Inflammatory AgentsDrugs, Chinese HerbalNF-kappa BPhosphatidylinositol 3-KinasestongluoDiabetic peripheral neuropathyHyperalgesiaNeuroprotectionStructural and functional damageZhenzhu Tongluo pills

Identifiers

PMID38429764
PMCPMC10908044
OpenAlexW4392360500

What OpenQuestion holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.