Evidence map›Paper›PMID 38429414›Full record

ArticleNature cancer2024

Modeling T cell temporal response to cancer immunotherapy rationalizes development of combinatorial treatment protocols.

Oren Barboy, Akhiad Bercovich, Hanjie Li, Yaniv Eyal-Lubling, Adam Yalin, Yuval Shapir Itai, Kathleen Abadie, Mor Zada, Eyal David, Shir Shlomi-Loubaton and 11 more

Abstract read
PubMed Publisher
In one paragraph

Article in Nature cancer, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
7.6field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 27 citations in OpenAlex.

  1. Article
  2. Review
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  4. Spatiotemporal dynamics of adoptively transferred stem-like CD8bioRxiv : the preprint server for biology · 2026
    Article
  5. Article
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  13. Microwave Ablation Combined with Flt3L Provokes Tumor-Specific Memory CD8Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025
    Article
  14. Article
  15. Review
  16. Article
  17. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

21 authors at 6 institutions in 4 countries.

Oren Barboy *Department of Systems Immunology, Weizmann Institute of Science, Rehovot, Israel.
Akhiad Bercovich *Department of Computer Science and Applied Mathematics and Department of Molecular Cell Biology, Weizmann Institute of Science, Rehovot, Israel.
Hanjie LiDepartment of Synthetic Immunology, Shenzhen Institutes of Advanced Technology, Shenzhen, China.
Yaniv Eyal-LublingCancer Research UK Cambridge Institute, University of Cambridge, Li Ka Shing Centre, Cambridge, UK.
Adam YalinDepartment of Systems Immunology, Weizmann Institute of Science, Rehovot, Israel.
Yuval Shapir ItaiDepartment of Systems Immunology, Weizmann Institute of Science, Rehovot, Israel.ORCID http://orcid.org/0000-0003-3430-1269
Kathleen AbadieDepartment of Systems Immunology, Weizmann Institute of Science, Rehovot, Israel.ORCID http://orcid.org/0000-0003-2021-7365
Mor ZadaDepartment of Systems Immunology, Weizmann Institute of Science, Rehovot, Israel.
Eyal DavidDepartment of Systems Immunology, Weizmann Institute of Science, Rehovot, Israel.
Shir Shlomi-LoubatonDepartment of Systems Immunology, Weizmann Institute of Science, Rehovot, Israel.
Yonatan KatzenelenbogenDepartment of Systems Immunology, Weizmann Institute of Science, Rehovot, Israel.
Diego Adhemar JaitinDepartment of Systems Immunology, Weizmann Institute of Science, Rehovot, Israel.
Chamutal GurDepartment of Systems Immunology, Weizmann Institute of Science, Rehovot, Israel.
Ido YofeDepartment of Systems Immunology, Weizmann Institute of Science, Rehovot, Israel.
Tali FefermanDepartment of Systems Immunology, Weizmann Institute of Science, Rehovot, Israel.
Merav CohenDepartment of Clinical Microbiology and Immunology, Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel.ORCID http://orcid.org/0000-0001-5536-1418
Rony DahanDepartment of Systems Immunology, Weizmann Institute of Science, Rehovot, Israel.ORCID http://orcid.org/0000-0002-8420-7601
Evan W NewellFred Hutchinson Cancer Research Center, University of Washington, Seattle, WA, USA.ORCID http://orcid.org/0000-0002-2889-243X
Aviezer LifshitzDepartment of Computer Science and Applied Mathematics and Department of Molecular Cell Biology, Weizmann Institute of Science, Rehovot, Israel.ORCID http://orcid.org/0000-0002-8458-9507
Amos TanayDepartment of Computer Science and Applied Mathematics and Department of Molecular Cell Biology, Weizmann Institute of Science, Rehovot, Israel. amos.tanay@weizmann.ac.il.ORCID http://orcid.org/0000-0001-9419-3824
Ido AmitDepartment of Systems Immunology, Weizmann Institute of Science, Rehovot, Israel. ido.amit@weizmann.ac.il.ORCID http://orcid.org/0000-0003-2968-877X
Weizmann Institute of Science · ILUniversity of Washington · USHebrew University of Jerusalem · ILShenzhen Institutes of Advanced Technology · CNTel Aviv University · ILUniversity of Cambridge · GB

Funding

Melanoma Research Alliance (MRA) 509044
6 · The paper itself

Abstract

Successful immunotherapy relies on triggering complex responses involving T cell dynamics in tumors and the periphery. Characterizing these responses remains challenging using static human single-cell atlases or mouse models. To address this, we developed a framework for in vivo tracking of tumor-specific CD8

Indexed as

CD8-Positive T-LymphocytesImmunotherapyTumor MicroenvironmentAnimalsCell Line, TumorDendritic CellsHumansImmune Checkpoint InhibitorsMiceNeoplasmsProgrammed Cell Death 1 ReceptorImmune Checkpoint InhibitorsProgrammed Cell Death 1 Receptor

Identifiers

PMID38429414
OpenAlexW4392355786

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.