ArticleCommunications biology2024
Unraveling the transcriptomic landscape of eye migration and visual adaptations during flatfish metamorphosis.
Article in Communications biology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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4 citing papers in PubMed, 8 citations in OpenAlex.
- UV-protective sunscreen compounds and their differential accumulation across ocular tissues in fish eyes from Baltic Sea.Scientific reports · 2026Article
- A thyroid hormone-mediated opsin switch initiates metamorphosis in a proto-vertebrate.Science advances · 2026Article
- Dna methylation dynamics associated with visual system remodeling during flatfish metamorphosis.Epigenetics & chromatin · 2025Article
- Unraveling the transcriptomic landscape of eye migration and visual adaptations during flatfish metamorphosis.Communications biology · 2024Article
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Authors and funding
8 authors at 2 institutions in 2 countries.
Funding
Abstract
Flatfish undergo a remarkable metamorphosis from symmetrical pelagic larvae to fully asymmetrical benthic juveniles. The most distinctive features of this transformation is the migration of one eye. The molecular role of thyroid hormone in the metamorphosis process in flatfishes is well established. However, the regulatory network that facilitates eye movement remains enigmatic. This paper presents a morphological investigation of the metamorphic process in turbot eyes, using advanced imaging techniques and a global view of gene expression. The study covers migrant and non-migrant eyes and aims to identify the genes that are active during ocular migration. Our transcriptomic analysis shows a significant up-regulation of immune-related genes. The analysis of eye-specific genes reveals distinct patterns during the metamorphic process. Myosin is highlighted in the non-migrant eye, while ependymin is highlighted in the migrant eye, possibly involved in optic nerve regeneration. Furthermore, a potential association between the alx3 gene and cranial restructuring has been identified. Additionally, it confirmed simultaneous adaptation to low light in both eyes, as described by changes in opsins expression during the metamorphic process. The study also revealed that ocular migration activates systems asynchronously in both eyes, providing insight into multifaceted reorganization processes during metamorphosis of flatfish.
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