Evidence map›Paper›PMID 38429289›Full record

ArticleNPJ microgravity2024

Dynamic changes in perivascular space morphology predict signs of spaceflight-associated neuro-ocular syndrome in bed rest.

Sutton B Richmond, Rachael D Seidler, Jeffrey J Iliff, Daniel L Schwartz, Madison Luther, Lisa C Silbert, Scott J Wood, Jacob J Bloomberg, Edwin Mulder, Jessica K Lee and 2 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in NPJ microgravity, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.5field-weighted citation impact, top 39% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 2 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 6 institutions in 3 countries.

Sutton B RichmondDepartment of Applied Physiology and Kinesiology, University of Florida, 1864, Stadium Rd., Gainesville, FL, USA.ORCID http://orcid.org/0000-0003-0205-7492
Rachael D SeidlerDepartment of Applied Physiology and Kinesiology, University of Florida, 1864, Stadium Rd., Gainesville, FL, USA.ORCID http://orcid.org/0000-0003-2452-9024
Jeffrey J IliffDepartment of Psychiatry and Behavioral Sciences, University of Washington School of Medicine, Seattle, WA, USA.
Daniel L SchwartzLayton-NIA Oregon Aging and Alzheimer's Disease Research Center, Department of Neurology, Oregon Health & Science University, Portland, OR, USA.
Madison LutherDepartment of Pediatrics, Division of Child Neurology, Doernbecher Children's Hospital, Oregon Health and Science University, Portland, OR, USA.ORCID http://orcid.org/0000-0002-1462-8689
Lisa C SilbertLayton-NIA Oregon Aging and Alzheimer's Disease Research Center, Department of Neurology, Oregon Health & Science University, Portland, OR, USA.
Scott J WoodNASA Johnson Space Center, Houston, TX, USA.ORCID http://orcid.org/0000-0002-2603-7552
Jacob J BloombergNASA Johnson Space Center, Houston, TX, USA.
Edwin MulderGerman Aerospace Center (DLR), Cologne, Germany.
Jessica K LeeDepartment of Applied Physiology and Kinesiology, University of Florida, 1864, Stadium Rd., Gainesville, FL, USA.
Alberto De LucaDepartment of Radiology, University Medical Center Utrecht, Utrecht, Netherlands.
Juan PiantinoDepartment of Pediatrics, Division of Child Neurology, Doernbecher Children's Hospital, Oregon Health and Science University, Portland, OR, USA. piantino@ohsu.edu.ORCID http://orcid.org/0000-0002-8861-5709
Oregon Health & Science University · USDeutsches Zentrum für Luft- und Raumfahrt e. V. (DLR) · DEJohnson Space Center · USUniversity of Florida · USUniversity Medical Center Utrecht · NLUniversity of Washington · US

Funding

Research Education ComponentP30AG066518 · NIA · OREGON HEALTH & SCIENCE UNIVERSITY · PI Zachary Beattie · 2020 to 2026
$28.6M
NIA NIH HHS P30 AG066518
6 · The paper itself

Abstract

During long-duration spaceflight, astronauts experience headward fluid shifts and expansion of the cerebral perivascular spaces (PVS). A major limitation to our understanding of the changes in brain structure and physiology induced by spaceflight stems from the logistical difficulties of studying astronauts. The current study aimed to determine whether PVS changes also occur on Earth with the spaceflight analog head-down tilt bed rest (HDBR). We examined how the number and morphology of magnetic resonance imaging-visible PVS (MV-PVS) are affected by HDBR with and without elevated carbon dioxide (CO

Identifiers

PMID38429289
PMCPMC10907584
OpenAlexW4392363440

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.