Evidence map›Paper›PMID 38428939›Full record

ArticleSouthern medical journal2024

Associations between Present-on-Admission Do-Not-Resuscitate Orders and Short-Term Outcomes in Patients with Pneumonia.

Megan M Sheehan, Marya D Zilberberg, Peter K Lindenauer, Thomas L Higgins, Peter B Imrey, Ning Guo, Abhishek Deshpande, Sarah D Haessler, Michael B Rothberg

Abstract read
In one paragraph

Article in Southern medical journal, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Megan M SheehanFrom the Hospital of the University of Pennsylvania, Philadelphia.
Marya D ZilberbergEviMed Research Group, Goshen, Massachusetts.
Peter K Lindenauer
Thomas L Higgins
Peter B ImreyDepartment of Quantitative Health Sciences.
Ning GuoDepartment of Quantitative Health Sciences.
Abhishek DeshpandeCenter for Value-Based Care Research, Cleveland Clinic, Cleveland, Ohio.
Sarah D HaesslerDepartment of Medicine, Division of Infectious Diseases, University of Massachusetts Chan Medical School-Baystate, Springfield, Massachusetts.
Michael B RothbergCenter for Value-Based Care Research, Cleveland Clinic, Cleveland, Ohio.

Funding

Reducing Antimicrobial Overuse in HCAP Through Personalized Antimicrobial RecommendationsR01HS024277 · AHRQ · CLEVELAND CLINIC FOUNDATION · PI ROTHBERG, MICHAEL B · 2015 to 2019
$2.5M
Using Large Observational Datasets to Improve Antibiotic Prescribing for Community-Acquired PneumoniaK08HS025026 · AHRQ · CLEVELAND CLINIC FOUNDATION · PI DESHPANDE, ABHISHEK · 2016 to 2020
$697k
AHRQ HHS K08 HS025026AHRQ HHS R01 HS024277
6 · The paper itself

Abstract

objectivesDo-not-resuscitate

methodsThis is a retrospective cohort study of 768,015 adult patients hospitalized with pneumonia from 2010 to 2015 in 646 US hospitals. The exposure was DNR orders present on admission. Secondary analyses stratified patients by predicted in-hospital mortality. Main outcomes included in-hospital mortality, length of stay, cost, intensive care admission, invasive mechanical ventilation, noninvasive ventilation, vasopressors, and dialysis initiation.

resultsOf 768,015 patients, 94,155 (12.3%) had an early DNR order. Compared with those without, patients with DNR orders were older (mean age 80.1 ± 10.6 years vs 67.8 ± 16.4 years), with higher comorbidity burden, intensive care use (31.6% vs 30.6%), and in-hospital mortality (28.2% vs 8.5%). After adjustment via propensity score weighting, these patients had higher mortality (odds ratio [OR] 2.39, 95% confidence interval [CI] 2.33-2.45) and lower use of intensive therapies such as vasopressors (OR 0.83, 95% CI 0.81-0.85) and invasive mechanical ventilation (OR 0.68, 95% CI 0.66-0.70). Although there was little relationship between predicted mortality and DNR orders, among those with highest predicted mortality, DNR orders were associated with lower intensive care use compared with those without (66.7% vs 80.8%).

conclusionsPatients with early DNR orders have higher in-hospital mortality rates than those without, but often receive intensive care. These orders have the most impact on the care of patients with the highest mortality risk.

Indexed as

PneumoniaResuscitation OrdersAdultAgedAged, 80 and overComorbidityHospitalizationHumansRetrospective Studies

Identifiers

PMID38428939
PMCPMC10914325

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.