Evidence map›Paper›PMID 38428504›Full record

ReviewJournal of biotechnology2024

Engineering carboxylic acid reductases and unspecific peroxygenases for flavor and fragrance biosynthesis.

Alejandra Agosto-Maldonado, Jiantao Guo, Wei Niu

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Journal of biotechnology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Alejandra Agosto-MaldonadoDepartment of Chemistry, University of Nebraska-Lincoln, Lincoln, Nebraska 68588, United States.
Jiantao GuoDepartment of Chemistry, University of Nebraska-Lincoln, Lincoln, Nebraska 68588, United States; The Nebraska Center for Integrated Biomolecular Communication (NCIBC), University of Nebraska-Lincoln, Lincoln, Nebraska 68588, United States.
Wei NiuDepartment of Chemical & Biomolecular Engineering, University of Nebraska-Lincoln, Lincoln, Nebraska 68588, United States; The Nebraska Center for Integrated Biomolecular Communication (NCIBC), University of Nebraska-Lincoln, Lincoln, Nebraska 68588, United States. Electronic address: wniu2@unl.edu.

Funding

Targeted mass spectrometry approaches to understand CART processing and recepter interactionsP20GM113126 · NIGMS · UNIVERSITY OF NEBRASKA LINCOLN · PI GUO, JIANTAO · 2016 to 2025
$20.8M
Developing synthetic chemical biology strategies for biochemical investigations and biomedical applicationsR35GM149322 · NIGMS · UNIVERSITY OF NEBRASKA LINCOLN · PI Jiantao Guo · 2023 to 2026
$1.5M
Defining, studying, and targeting sulfated tyrosine residues of cell surface receptors for disease treatmentR01GM147785 · NIGMS · UNIVERSITY OF NEBRASKA LINCOLN · PI GUO, JIANTAO · 2022 to 2022
$301k
NIGMS NIH HHS P20 GM113126NIGMS NIH HHS R01 GM147785NIGMS NIH HHS R35 GM149322
6 · The paper itself

Abstract

Emerging consumer demand for safer, more sustainable flavors and fragrances has created new challenges for the industry. Enzymatic syntheses represent a promising green production route, but the broad application requires engineering advancements for expanded diversity, improved selectivity, and enhanced stability to be cost-competitive with current methods. This review discusses recent advances and future outlooks for enzyme engineering in this field. We focus on carboxylic acid reductases (CARs) and unspecific peroxygenases (UPOs) that enable selective productions of complex flavor and fragrance molecules. Both enzyme types consist of natural variants with attractive characteristics for biocatalytic applications. Applying protein engineering methods, including rational design and directed evolution in concert with computational modeling, present excellent examples for property improvements to unleash the full potential of enzymes in the biosynthesis of value-added chemicals.

Indexed as

OdorantsOxidoreductasesMixed Function Oxygenasescarboxylic acid reductaseMixed Function OxygenasesOxidoreductasesperoxygenaseCarboxylic Acid Reductase (CAR)Directed evolutionFlavor and fragranceProtein engineeringUnspecific Peroxygenase (UPO)

Identifiers

PMID38428504
PMCPMC11062483

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.