ArticleCell reports. Medicine2024
Mediator complex subunit 1 architects a tumorigenic Treg cell program independent of inflammation.
Open access · goldAbstract read
In one paragraph
Article in Cell reports. Medicine, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
1.0field-weighted citation impact, top 27% of its field
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
4 citing papers in PubMed, 4 citations in OpenAlex.
- Endothelium-Treg Communication Through Extracellular Vesicle Transfer Exacerbates Acute Respiratory Distress Syndrome.Journal of extracellular vesicles · 2026Article
- Deciphering the causal relationships between plasma metabolites, peripheral cells, inflammatory factors and DLBCL for discovering novel therapeutic targets.Discover oncology · 2025Article
- Succinate drives gut inflammation by promoting FOXP3 degradation through a molecular switch.Nature immunology · 2025Article
- Genomic structural equation modeling elucidates the shared genetic architecture of allergic disorders.Journal of translational medicine · 2025Article
Corrections and comments
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Authors and funding
25 authors at 1 institution in 1 country.
Shuvam M ChaudhuriDepartment of Pathology, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA.
Samuel E WeinbergDepartment of Pathology, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA.
Dongmei WangDepartment of Pathology, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA; Robert H. Lurie Comprehensive Cancer Center, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA.
Lenore K YalomDepartment of Pathology, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA.
Elena MontautiDepartment of Pathology, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA.
Radhika IyerDepartment of Pathology, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA.
Amy Y TangDepartment of Pathology, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA.
Manuel A Torres AcostaDivision of Pulmonary and Critical Care Medicine, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA; Medical Scientist Training Program, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA.
Jian ShenDepartment of Pathology, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA.
Nikita L ManiDepartment of Pathology, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA.
Shengnan WangDepartment of Pathology, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA.
Kun LiuDepartment of Pathology, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA.
Weiyuan LuDepartment of Pathology, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA.
Triet M BuiDepartment of Pathology, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA.
Laura D ManzanaresDepartment of Pathology, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA.
Zeinab DehghaniDepartment of Pathology, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA.
Ching Man WaiCenter for Genetic Medicine, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA; Department of Biochemistry and Molecular Genetics, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA.
Beixue GaoDepartment of Pathology, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA.
Juncheng WeiDepartment of Pathology, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA.
Feng YueDepartment of Pathology, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA; Robert H. Lurie Comprehensive Cancer Center, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA; Department of Biochemistry and Molecular Genetics, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA.
Weiguo CuiDepartment of Pathology, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA.
Benjamin D SingerDivision of Pulmonary and Critical Care Medicine, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA; Department of Biochemistry and Molecular Genetics, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA.
Ronen SumaginDepartment of Pathology, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA.
Yana ZhangDepartment of Pathology, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA.
Deyu FangDepartment of Pathology, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA; Robert H. Lurie Comprehensive Cancer Center, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA. Electronic address: fangd@northwestern.edu.
Northwestern University · US
Funding
Tumor Environment and Metastasis (TEAM) Research ProgramP30CA060553 · NCI · NORTHWESTERN UNIVERSITY AT CHICAGO · PI LEONIDAS C. PLATANIAS · 1993 to 2026
$153.9MTissue resident macrophages regulate proteostasis in the aging lungP01AG049665 · NIA · NORTHWESTERN UNIVERSITY AT CHICAGO · PI GR Scott Budinger · 2015 to 2026
$26.9MTechnology CoreU19AI135964 · NIAID · NORTHWESTERN UNIVERSITY AT CHICAGO · PI LUIS A. Nunes AMARAL · 2018 to 2026
$24.7MThe Cell Phenotyping and Mouse CoreP01HL154998 · NHLBI · NORTHWESTERN UNIVERSITY AT CHICAGO · PI KAREN M RIDGE · 2021 to 2026
$18.9MTraining Program In Lung SciencesT32HL076139 · NHLBI · NORTHWESTERN UNIVERSITY AT CHICAGO · PI KAREN M RIDGE, Jacob I Sznajder · 2004 to 2026
$9.6MMedical Scientist Training ProgramT32GM144295 · NIGMS · NORTHWESTERN UNIVERSITY AT CHICAGO · PI ALAN R HAUSER · 2022 to 2026
$9.1MTRAINING IN METABOLISM, DIABETES AND ENDOCRINOLOGYT32DK007169 · NIDDK · NORTHWESTERN UNIVERSITY AT CHICAGO · PI Joseph Bass · 1988 to 2026
$6.6MNovel Role of Hepatic SEL1L-HRD1 ERAD in FGF21 Gene TranscriptionR01DK120330 · NIDDK · UNIVERSITY OF VIRGINIA · PI Deyu Fang, Ling Qi · 2018 to 2026
$4.9MMechanisms of regulatory T cell-mediated recovery from severe viral pneumoniaR01HL149883 · NHLBI · NORTHWESTERN UNIVERSITY AT CHICAGO · PI Benjamin David Singer · 2020 to 2026
$4.1MA deubiquitination module controls Treg adaptation to tumor microenvironmentR01CA257520 · NCI · NORTHWESTERN UNIVERSITY AT CHICAGO · PI FANG, DEYU, ZHANG, BIN · 2021 to 2025
$2.8MRegulation of Rhythmic m6A RNA Modification by ER‐associated DegradationR01DK126908 · NIDDK · WAYNE STATE UNIVERSITY · PI FANG, DEYU, ZHANG, KEZHONG · 2021 to 2024
$2.2MVascular endothelial cells and macrophages coordinate neutrophil trafficking in inflammationR01AI153568 · NIAID · NORTHWESTERN UNIVERSITY AT CHICAGO · PI SUMAGIN, RONEN · 2021 to 2025
$1.9MNCI NIH HHS P30 CA060553NCI NIH HHS R01 CA232347NCI NIH HHS R01 CA257520NHLBI NIH HHS P01 HL154998NHLBI NIH HHS R01 HL149883NHLBI NIH HHS R01 HL153122NHLBI NIH HHS T32 HL076139NIAID NIH HHS R01 AI153568NIAID NIH HHS U19 AI135964NIDDK NIH HHS R01 DK120330NIDDK NIH HHS R01 DK124199NIDDK NIH HHS R01 DK126908NIDDK NIH HHS T32 DK007169NIGMS NIH HHS T32 GM144295NIGMS NIH HHS T32 GM149439NIH HHS S10 OD025120
Abstract
While immunotherapy has revolutionized cancer treatment, its safety has been hampered by immunotherapy-related adverse events. Unexpectedly, we show that Mediator complex subunit 1 (MED1) is required for T regulatory (T
Indexed as
NeoplasmsT-Lymphocytes, RegulatoryAnimalsForkhead Transcription FactorsHumansInflammationMediator Complex Subunit 1MiceTumor MicroenvironmentForkhead Transcription FactorsMediator Complex Subunit 1ATAC-seqautoimmunitydifferentiationFOXP3MED1scRNA-seqtumor immunologytumor T regulatory cell
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.