ArticleCell2024
The CARD8 inflammasome dictates HIV/SIV pathogenesis and disease progression.
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Article in Cell, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers.
0numbers the graph read from it
0cells of the map it votes in
38citing papers in PubMed
13.2field-weighted citation impact, top 1% of its field
What it found
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
38 citing papers in PubMed, 45 citations in OpenAlex.
- The gasdermin family: from pyroptosis mechanisms to therapeutic targets.Signal transduction and targeted therapy · 2026Review
- Reverse genetics in humanized mice reveals CARD8-mediated pyroptosis causing pancytopenia in human DPP9 deficiency.The Journal of clinical investigation · 2026Article
- Cell-autonomous immunity as an integrated immune network against bacterial and viral pathogens.Nature microbiology · 2026Review
- Reverse genetics in humanized mice reveals CARD8-mediated pyroptosis causing pancytopenia in human DPP9 deficiency.bioRxiv : the preprint server for biology · 2026Article
- A tissue-intrinsic mechanism sensitizes HIV-1 particles for TLR-triggered innate immune responses.Nature communications · 2026Article
- Recent advances in the construction of humanized animal models and applications in translational medicine.Animal models and experimental medicine · 2026Review
- Gout Inflammation Time Programming: Molecular Clock from Crystal Triggering to Tissue Remodeling.International journal of molecular sciences · 2026Review
- Antiviral Inflammasomes and How to Find Them.Viruses · 2026Review
- Caspase Recruitment Domain Family Member 8: A Favorable Target in the Pathogenesis of Atherosclerosis.Reviews in cardiovascular medicine · 2026Review
- Investigation of CNS damage following HIV infection and methamphetamine exposure using human iPSC-derived microglia and 3D cerebral assembloid models.bioRxiv : the preprint server for biology · 2025Article
- Grand Challenges on HIV/AIDS in China - The 5th Symposium, Yunnan 2024.Emerging microbes & infections · 2025Article
- Inflammasomes and pyroptosis in cancer: mechanisms and therapeutic advances.Journal of hematology & oncology · 2025Review
- Evasion of CARD8 activation during HIV-1 assembly.Science advances · 2025Article
- Molecular mechanisms and regulation of inflammasome activation and signaling: sensing of pathogens and damage molecular patterns.Cellular & molecular immunology · 2025Review
- BACH2 promotes seeding and establishment of long-lived HIV-1 reservoir in memory CD4Cell reports. Medicine · 2025Article
- HIV-2 evades restriction by ZAP through adaptations in the U3 LTR region despite increased CpG levels.Nucleic acids research · 2025Article
- SAMHD1 enhances HIV-1-induced apoptosis in monocytic cells via the mitochondrial pathway.mBio · 2025Article
- In vitro HIV DNA integration in STAT3 drives T cell persistence-A model of HIV-associated T cell lymphoma.PLoS pathogens · 2025Article
- Article
- HIV, Inflammation, and Immunometabolism: A Model of the Inflammatory Theory of Disease.Viruses · 2025Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
12 authors at 4 institutions in 1 country.
Qiankun WangDivision of Infectious Diseases, Department of Medicine, Washington University School of Medicine, Saint Louis, MO, USA.
Kolin M ClarkDivision of Infectious Diseases, Department of Medicine, Washington University School of Medicine, Saint Louis, MO, USA.
Ritudhwaj TiwariDivision of Infectious Diseases, Department of Medicine, Washington University School of Medicine, Saint Louis, MO, USA.
Nagarajan RajuDivision of Microbiology and Immunology, Emory National Primate Research Center, Emory University, Atlanta, GA, USA.
Gregory K TharpDivision of Microbiology and Immunology, Emory National Primate Research Center, Emory University, Atlanta, GA, USA.
Jeffrey RogersHuman Genome Sequencing Center and Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX, USA.
R Alan HarrisHuman Genome Sequencing Center and Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX, USA.
Muthuswamy RaveendranHuman Genome Sequencing Center and Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX, USA.
Steven E BosingerDepartment of Pathology and Laboratory Medicine, Emory University School of Medicine, Atlanta, GA, USA; Division of Microbiology and Immunology, Emory National Primate Research Center, Emory University, Atlanta, GA, USA.
Tricia H BurdoDepartment of Microbiology, Immunology, and Inflammation, Center for Neurovirology and Gene Editing, Lewis Katz School of Medicine at Temple University, Philadelphia, PA, USA.
Guido SilvestriDepartment of Pathology and Laboratory Medicine, Emory University School of Medicine, Atlanta, GA, USA; Division of Microbiology and Immunology, Emory National Primate Research Center, Emory University, Atlanta, GA, USA.
Liang ShanDivision of Infectious Diseases, Department of Medicine, Washington University School of Medicine, Saint Louis, MO, USA; Andrew M. and Jane M. Bursky Center for Human Immunology and Immunotherapy Programs, Washington University School of Medicine, Saint Louis, MO, USA. Electronic address: liang.shan@wustl.edu.
Emory University · USWashington University in St. Louis · USBaylor College of Medicine · USTemple University · US
Funding
CRISPR for CureUM1AI164568 · NIAID · TEMPLE UNIV OF THE COMMONWEALTH · PI Tricia Helen Burdo, Kamel Khalili · 2021 to 2026
$27.7MUnderstand the role of CARD8 inflammasome in HIV-1 infectionR01AI162203 · NIAID · WASHINGTON UNIVERSITY · PI PINZONE, MARILIA RITA · 2021 to 2025
$3.5MHarnessing the CARD8 Inflammasome for HIV Reservoir EliminationR01AI176594 · NIAID · WASHINGTON UNIVERSITY · PI Marilia Rita Pinzone, Francesco Roberto Simonetti · 2023 to 2026
$3.2MNovel Strategies to Enhance Effector Cell Functions for Antibody-Mediated Clearance of HIV-1 InfectionR01AI155162 · NIAID · WASHINGTON UNIVERSITY · PI SHAN, LIANG · 2020 to 2024
$3.1MDetermining and Overcoming barriers in translating HIV-1 protease mediated activation of the CARD8 inflammasome to HIV cure researchF31AI165251 · NIAID · WASHINGTON UNIVERSITY · PI CLARK, KOLIN · 2022 to 2023
$54kNIAID NIH HHS F31 AI165251NIAID NIH HHS R01 AI155162NIAID NIH HHS R01 AI162203NIAID NIH HHS R01 AI176594NIAID NIH HHS UM1 AI164568
Abstract
While CD4
Indexed as
HIV InfectionsInflammasomesSimian Acquired Immunodeficiency SyndromeAnimalsCARD Signaling Adaptor ProteinsCD4-Positive T-LymphocytesDisease ProgressionHIVHumansMiceNeoplasm ProteinsSimian Immunodeficiency VirusViremiaCARD8 protein, humanCARD Signaling Adaptor ProteinsInflammasomesNeoplasm ProteinsCARD8caspase 1CD4(+) T cellsHIVinflammasomenon-human primatespyroptosisSIVviral entryviral protease
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.