ArticleEnvironmental science & technology2024
Direct Analysis of Marine Dissolved Organic Matter Using LC-FT-ICR MS.
Article in Environmental science & technology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
14 citing papers in PubMed, 42 citations in OpenAlex.
- Molecular signatures of electrochemically reduced peatland dissolved organic matter resolved by liquid chromatography Fourier transform ion cyclotron resonance mass spectrometry.Analytical and bioanalytical chemistry · 2026Article
- Ammonification Process Is Limited by Transformation of Medium Molecular Weight Nitrogenous Organics but Not Hydrolysis of Proteins.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Chromatography Coupled to High-Resolution Mass Spectrometry Analysis Reveals Flaws in van Krevelen Compound Class Assignments in DOM.Environmental science & technology · 2026Article
- Determination of stable carbon isotope ratios for molecules in natural organic matter using ESI FT-ICR MS.Science advances · 2026Article
- Graph-based understanding of isomeric diversity in complex dissolved organic matter.Communications chemistry · 2026Article
- Practical guide for marine exo-metabolomic sample preparation.The ISME journal · 2026Review
- Functional Group Distribution Shapes Chemical Properties of Degraded Terrestrial and Marine Dissolved Organic Matter.Environmental science & technology · 2025Article
- Underestimated input of terrestrial dissolved organic carbon to the ocean.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Improvement of Electrospray Ionization Response Linearity and Quantification in Dissolved Organic Matter Using Synthetic Deuterated Internal Standards.Analytical chemistry · 2025Article
- Temporal Dynamics and Intermediate Product Formation in DOM Phototransformation Revealed by Liquid Chromatography Ultrahigh-Resolution Mass Spectrometry.Environmental science & technology · 2025Article
- Constraining biorecalcitrance of carboxyl-rich alicyclic molecules in the ocean.Science advances · 2025Article
- Molecular-Level Insights into Recalcitrant Ozonation Products from Effluent Organic Matter.Environmental science & technology · 2025Article
- Combined Quantification and Characterization of Dissolved Organic Matter by Liquid Chromatography-Mass Spectrometry Using Charged Aerosol Detection.Journal of the American Society for Mass Spectrometry · 2024Article
- Fourier Transform Ion Cyclotron Resonance Mass Spectrometry Applications for Metabolomics.Biomedicines · 2024Review
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Marine dissolved organic matter (DOM) is an important component of the global carbon cycle, yet its intricate composition and the sea salt matrix pose major challenges for chemical analysis. We introduce a direct injection, reversed-phase liquid chromatography ultrahigh resolution mass spectrometry approach to analyze marine DOM without the need for solid-phase extraction. Effective separation of salt and DOM is achieved with a large chromatographic column and an extended isocratic aqueous step. Postcolumn dilution of the sample flow with buffer-free solvents and implementing a counter gradient reduced salt buildup in the ion source and resulted in excellent repeatability. With this method, over 5,500 unique molecular formulas were detected from just 5.5 nmol carbon in 100 μL of filtered Arctic Ocean seawater. We observed a highly linear detector response for variable sample carbon concentrations and a high robustness against the salt matrix. Compared to solid-phase extracted DOM, our direct injection method demonstrated superior sensitivity for heteroatom-containing DOM. The direct analysis of seawater offers fast and simple sample preparation and avoids fractionation introduced by extraction. The method facilitates studies in environments, where only minimal sample volume is available e.g. in marine sediment pore water, ice cores, or permafrost soil solution. The small volume requirement also supports higher spatial (e.g., in soils) or temporal sample resolution (e.g., in culture experiments). Chromatographic separation adds further chemical information to molecular formulas, enhancing our understanding of marine biogeochemistry, chemodiversity, and ecological processes.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.