Evidence map›Paper›PMID 38427736›Full record

ArticleScience advances2024

Structure of the PCNA unloader Elg1-RFC.

Fengwei Zheng, Nina Y Yao, Roxana E Georgescu, Huilin Li, Michael E O'Donnell

Abstract read
In one paragraph

Article in Science advances, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Mechanistic diversity of clamp loading at small DNA gaps.The Journal of biological chemistry · 2026
    Review
  2. First genome report ofFrontiers in fungal biology · 2026
    Article
  3. Article
  4. PCNA is a nucleotide exchange factor for the clamp loader ATPase complex.Proceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  5. PCNA is a Nucleotide Exchange Factor for the Clamp Loader ATPase Complex.bioRxiv : the preprint server for biology · 2025
    Article
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Fengwei ZhengDepartment of Structural Biology, Van Andel Institute, Grand Rapids, MI, USA.ORCID 0000-0002-7139-4831
Nina Y YaoDNA Replication Laboratory and Howard Hughes Medical Institute, The Rockefeller University, NY, New York, USA.ORCID 0000-0002-4728-6531
Roxana E GeorgescuDNA Replication Laboratory and Howard Hughes Medical Institute, The Rockefeller University, NY, New York, USA.ORCID 0000-0002-1882-2358
Huilin LiDepartment of Structural Biology, Van Andel Institute, Grand Rapids, MI, USA.ORCID 0000-0001-8085-8928
Michael E O'DonnellDNA Replication Laboratory and Howard Hughes Medical Institute, The Rockefeller University, NY, New York, USA.ORCID 0000-0001-9002-4214

Funding

Structural mechanism of DNA replicationR35GM131754 · NIGMS · VAN ANDEL RESEARCH INSTITUTE · PI Huilin Li · 2019 to 2026
$6.0M
Biochemistry of Eukaryotic Replication Fork and DNA RepairR35GM148159 · NIGMS · ROCKEFELLER UNIVERSITY · PI MICHAEL E O'DONNELL · 2023 to 2026
$1.7M
Howard Hughes Medical InstituteNIGMS NIH HHS R35 GM131754NIGMS NIH HHS R35 GM148159
6 · The paper itself

Abstract

During DNA replication, the proliferating cell nuclear antigen (PCNA) clamps are loaded onto primed sites for each Okazaki fragment synthesis by the AAA

Indexed as

DNA-Binding ProteinsSaccharomyces cerevisiae ProteinsCarrier ProteinsDNAProliferating Cell Nuclear AntigenReplication Protein CCarrier ProteinsDNADNA-Binding ProteinsElg1 protein, S cerevisiaePOL30 protein, S cerevisiaeProliferating Cell Nuclear AntigenReplication Protein CSaccharomyces cerevisiae Proteins

Identifiers

PMID38427736
PMCPMC10906927

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.