Evidence map›Paper›PMID 38427352›Full record

ArticleJAMA network open2024

Self-Reported Everyday Functioning After COVID-19 Infection.

Theodore J Iwashyna, Valerie A Smith, Sarah Seelye, Amy S B Bohnert, Edward J Boyko, Denise M Hynes, George N Ioannou, Matthew L Maciejewski, Ann M O'Hare, Elizabeth M Viglianti and 7 more

Registry-linked trialAbstract read
In one paragraph

Article in JAMA network open, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05394025 (COVID-19 Observational Research Collaboratory - Long-Term Outcomes), which is not on this map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05394025 completednot on this map

COVID-19 Observational Research Collaboratory - Long-Term Outcomes (LTO) Study

TypeobservationalSponsorVA Office of Research and DevelopmentRan2022 to 2024Enrolled479ConditionsCOVID-19, SARS-CoV-2 Infection
3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors.

Theodore J IwashynaVA Center for Clinical Management Research, Ann Arbor VA, Ann Arbor, Michigan.
Valerie A SmithCenter of Innovation to Accelerate Discovery and Practice Transformation, Durham VA Medical Center, Durham, North Carolina.
Sarah SeelyeVA Center for Clinical Management Research, Ann Arbor VA, Ann Arbor, Michigan.
Amy S B BohnertVA Center for Clinical Management Research, Ann Arbor VA, Ann Arbor, Michigan.
Edward J BoykoSeattle Epidemiologic Research and Information Center, VA Puget Sound Health Care System, Seattle, Washington.
Denise M HynesVA Portland Healthcare System, Center to Improve Veteran Involvement in Care, Portland, Oregon.
George N IoannouUniversity of Washington, Seattle.
Matthew L MaciejewskiCenter of Innovation to Accelerate Discovery and Practice Transformation, Durham VA Medical Center, Durham, North Carolina.
Ann M O'HareUniversity of Washington, Seattle.
Elizabeth M VigliantiVA Center for Clinical Management Research, Ann Arbor VA, Ann Arbor, Michigan.
Theodore S BerkowitzCenter of Innovation to Accelerate Discovery and Practice Transformation, Durham VA Medical Center, Durham, North Carolina.
John PuraCenter of Innovation to Accelerate Discovery and Practice Transformation, Durham VA Medical Center, Durham, North Carolina.
James WomerSchool of Medicine, Johns Hopkins University, Baltimore, Maryland.
Lee A KamphuisVA Center for Clinical Management Research, Ann Arbor VA, Ann Arbor, Michigan.
Max L MonahanVA Center for Clinical Management Research, Ann Arbor VA, Ann Arbor, Michigan.
C Barrett BowlingCenter of Innovation to Accelerate Discovery and Practice Transformation, Durham VA Medical Center, Durham, North Carolina.
VA HSR&D COVID-19 Observational Research Collaboratory (CORC)

Funding

MULTIDISCIPLINARY TRAINING PROGRAM IN LUNG DISEASEST32HL007534 · NHLBI · JOHNS HOPKINS UNIVERSITY · PI Nadia N Hansel, Larissa A. Shimoda · 1985 to 2026
$28.3M
HSR&D Senior Research Career Scientist AwardIK6HX003395 · VA · PORTLAND VA MEDICAL CENTER · PI Denise M. Hynes · 2021 to 2026
–
HSRD VA IK6 HX003395NHLBI NIH HHS T32 HL007534
6 · The paper itself

Abstract

Importance: Changes in everyday functioning are crucial to assessing the long-term impact of COVID-19 infection. Objective: To examine the impact of COVID-19 infection on everyday functioning 18 months after infection among veterans with and without histories of COVID-19 infection. Design, Setting, and Participants: This cohort study used data from the US Veterans Affairs (VA) and included 186 veterans who had COVID-19 between October 2020 and April 2021 (ie, COVID-19 cohort) and 186 matched comparators who did not have documented COVID-19 infections (ie, control cohort). This match balanced the risk of COVID-19 based on 39 variables measured in the 24 months before infection or match, using principles of target trial emulation. Data were analyzed from December 2022 to December 2023. Exposure: First documented COVID-19. Main Outcome and Measures: The differences in self-reported everyday functioning 18 months after COVID-19 infection were estimated and compared with their matched comparators. Within-matched pair logistic and linear regressions assessed differences in outcomes and were weighted to account for sampling and nonresponse. Results: Among the 186 matched pairs of participants, their weighted mean age was 60.4 (95% CI, 57.5 to 63.2) years among veterans in the COVID-19 cohort (weighted sample, 91 459 of 101 133 [90.4%] male; 30 611 [30.3%] Black or African American veterans; 65 196 [64.4%] White veterans) and 61.1 (95% CI, 57.8 to 64.4) years among their comparators in the control cohort (91 459 [90.4%] male; 24 576 [24.3%] Black or African American veterans; 70 157 [69.4%] White veterans). A high proportion of veterans in the COVID-19 cohort (weighted percentage, 44.9% [95% CI, 34.2% to 56.2%]) reported that they could do less than what they felt they could do at the beginning of 2020 compared with the control cohort (weighted percentage, 35.3%; [95% CI, 25.6% to 46.4%]; within-matched pair adjusted odds ratio [OR], 1.52 [95% CI, 0.79 to 2.91]). There was no association of documented COVID-19 infection with fatigue, substantial pain, limitations in either activities of daily living and instrumental activities of daily living, severely curtailed life-space mobility, employment, or mean health-related quality of life on a utility scale. Conclusions and Relevance: In this cohort study of veterans with and without documented COVID-19, many reported a substantial loss of everyday functioning during the pandemic regardless of whether or not they had a documented infection with COVID-19. Future work with larger samples is needed to validate the estimated associations.

Indexed as

COVID-19Activities of Daily LivingCohort StudiesFemaleHumansMaleMiddle AgedQuality of LifeSelf ReportVeterans

Identifiers

PMID38427352
PMCPMC10907923

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.