Evidence map›Paper›PMID 38427311›Full record

ArticleBreast cancer research and treatment2024

Primary MALT lymphoma of the breast: pathological and radiological characteristics.

Yukiko Shibahara, Jan M A Delabie, Supriya Kulkarni, Allison Grant, Anca Prica, David R McCready, Susan J Done

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Article in Breast cancer research and treatment, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
1.7field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 4 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 2 countries.

Yukiko ShibaharaDepartment of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, ON, Canada.
Jan M A DelabieDepartment of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, ON, Canada.
Supriya KulkarniDepartment of Medical Imaging, University of Toronto, Toronto, ON, Canada.
Allison GrantDepartment of Medical Imaging, University of Toronto, Toronto, ON, Canada.
Anca PricaDepartment of Medical Oncology and Hematology, Princess Margaret Cancer Centre, Toronto, ON, Canada.
David R McCreadyDepartment of Surgery, University of Toronto, Toronto, ON, Canada.
Susan J DoneDepartment of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, ON, Canada. susan.done@uhn.ca.ORCID http://orcid.org/0000-0002-1770-988X
University Health Network · CA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposePrimary Mucosa-associated lymphoid tissue (MALT) lymphoma is a rare diagnosis in the breast, and clinical diagnosis based on radiological features is often challenging. This study aimed to evaluate the clinicopathological, and radiological characteristics of the patients diagnosed with primary breast MALT lymphoma.

methodsThis study examined 18 cases of primary MALT lymphoma of the breast diagnosed at a single tertiary center between January 2002 to December 2020. Medical charts, radiological imaging and original pathology slides were reviewed for each case.

resultsAll cases were female (gender assigned at birth) and presented with a palpable mass or an incidental imaging finding. Imaging presentation ranged from mammographic asymmetries, circumscribed masses, and ultrasound masses lacking suspicious features. Seventeen cases were biopsied under ultrasound; one received a diagnostic excision biopsy. Microscopic examination of the breast specimens demonstrated atypical small lymphocyte infiltration with plasmacytoid differentiation and rare lymphoepithelial lesions. Immunohistochemistry was performed in all cases and established the diagnosis. Most patients were treated with radiotherapy, and only three were treated with chemotherapy. The median follow-up period was 4 years and 7.5 months, and all patients were alive at the last follow-up.

conclusionPrimary MALT breast lymphomas are usually indolent and non-systemic, and local radiotherapy may effectively alleviate local symptoms. Radiological findings show overlap with benign morphological features, which can delay the diagnosis of this unusual etiology. Although further studies involving a larger cohort could help establish the clinical and radiological characteristics of primary breast MALT lymphomas, pathology remains the primary method of diagnosis. TRIAL REGISTRATION NUMBER: University Health Network Ethics Committee (CAPCR/UHN REB number 19-5844), retrospectively registered.

Indexed as

Breast NeoplasmsLymphoma, B-Cell, Marginal ZoneMammographyAdultAgedBiopsyBreastFemaleFollow-Up StudiesHumansMiddle AgedRetrospective StudiesBreast mammogramBreast ultrasoundExtranodal marginal zone lymphomaMALT lymphomaPrimary breast lymphoma

Identifiers

PMID38427311
OpenAlexW4392386270

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.