Evidence map›Paper›PMID 38427243›Full record

ArticleMethods in molecular biology (Clifton, N.J.)2024

Quantitative Investigation of Neuroprotective Role of ROR1 in a Cell Culture Model of Alzheimer's Disease.

Kaushik Chanda, Debashis Mukhopadhyay

Abstract read
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In one paragraph

Article in Methods in molecular biology (Clifton, N.J.), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact, top 92% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 0 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 2 institutions in 2 countries.

Kaushik ChandaDepartment of Neuroscience, UF Scripps Biomedical Research, Jupiter, FL, USA. kaushik.chanda@ufl.edu.ORCID 0000-0002-8600-5210
Debashis MukhopadhyayBiophysics and Structural Genomics Division, Saha Institute of Nuclear Physics, HBNI, Kolkata, India. debashis.mukhopadhyay@saha.ac.in.ORCID 0000-0002-4516-2260
Saha Institute of Nuclear Physics · INScripps Research Institute · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Cytoskeletal and microtubule atrophy are major hallmarks of Alzheimer's disease (AD). A method to investigate endogenous proteins that can interact/stabilize the cytoskeleton (under pathological cues) is rare. Here, we describe how receptor tyrosine kinase-like orphan receptor 1 (ROR1), a receptor tyrosine kinase (RTK), can act as a neuroprotective molecule by promoting neurite outgrowth, stabilizing cytoskeletal components, and altering the dynamics of actin assembly in a cell culture model of AD.

Indexed as

Alzheimer DiseaseActinsCell Culture TechniquesCytoskeletonHumansReceptor Tyrosine Kinase-like Orphan ReceptorsActinsReceptor Tyrosine Kinase-like Orphan ReceptorsROR1 protein, humanAlzheimer’s diseaseConfocal microscopyNeuroprotectionROR1RTK

Identifiers

PMID38427243
OpenAlexW4392398034

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.