Evidence map›Paper›PMID 38427071›Full record

SynthesisNeuroradiology2024

Brain imaging prior to thrombectomy in the late window of large vessel occlusion ischemic stroke: a systematic review and meta-analysis.

Chun-Hsien Lin, Bruce Ovbiagele, David S Liebeskind, Jeffrey L Saver, Meng Lee

Abstract readMeta-AnalysisSystematic Review
PubMed Publisher
In one paragraph

Synthesis in Neuroradiology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed, 1 pooled it
0.8field-weighted citation impact, top 29% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 1 synthesis or guideline pooled it, 2 citations in OpenAlex.

  1. Pooled it
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 4 institutions in 2 countries.

Chun-Hsien LinDivision of Neurology, Department of Internal Medicine, Ditmanson Medical Foundation, Chia-Yi Christian Hospital, Chiayi, Taiwan.
Bruce OvbiageleDepartment of Neurology, University of California, San Francisco, San Francisco, CA, USA.
David S LiebeskindComprehensive Stroke Center and Department of Neurology, University of California, Los Angeles, Los Angeles, CA, USA.
Jeffrey L SaverComprehensive Stroke Center and Department of Neurology, University of California, Los Angeles, Los Angeles, CA, USA.
Meng LeeDepartment of Neurology, Chang Gung University College of Medicine, Chang Gung Memorial Hospital, Chiayi Branch, Puzi, Taiwan. menglee5126@gmail.com.ORCID http://orcid.org/0000-0002-7491-0571
University of California, Los Angeles · USChang Gung University · TWChia-Yi Christian Hospital · TWUniversity of California, San Francisco · US

Funding

Chang Gung Memorial Hospital CMRPG6H0191Chang Gung Memorial Hospital CMRPG6H0441National Science and Technology Council 109-2314-B-182-033-National Science and Technology Council MOST 108-2314-B-182-017National Science and Technology Council MOST 110-2314-B-182-036 -MY2
6 · The paper itself

Abstract

purposeOptimal imaging modalities to select patients for endovascular thrombectomy (EVT) in the late window of acute ischemic stroke due to large vessel occlusions (AIS-LVO) are not known. We conducted a systematic review comparing outcomes of patients selected by non-contrast computed tomography (NCCT)/CT angiography (CTA) vs. those selected by CT perfusion (CTP) or magnetic resonance imaging (MRI) for EVT in these patients.

methodsWe searched PUBMED, EMBASE, and the Cochrane Library from January 1, 2000, to July 15, 2023, to identify studies comparing outcomes of patients selected for EVT by NCCT/CTA vs. CTP or MRI in the late time window for AIS-LVO. Primary outcome was independence (mRS 0-2) at 90 days or discharge. Secondary outcomes were symptomatic intracranial hemorrhage (sICH) and mortality. We pooled data across studies based on an inverse variance method.

resultsSix cohort studies with 4208 patients were included. Pooled results showed no significant difference in the rate of independence at 90 days or discharge (RR 0.96, 95% CI 0.88-1.03) and sICH (RR 1.26, 0.85-1.86) between patients selected by NCCT/CTA vs. CTP or MRI for EVT in the late window of AIS-LVO. However, patients selected by NCCT/CTA vs. CTP or MRI for EVT were associated with a higher risk of mortality (RR 1.21, 1.06-1.39).

conclusionFor AIS-LVO in the late window, patients selected by NCCT/CTA compared with those selected by CTP or MRI for EVT might have a comparable rate of functional independence and sICH. Baseline NCCT/CTA may triage AIS-LVO in the late window.

Indexed as

Ischemic StrokeThrombectomyCerebral AngiographyComputed Tomography AngiographyEndovascular ProceduresHumansMagnetic Resonance ImagingComputed tomography angiographyEndovascular thrombectomyLarge vessel occlusionsLate windowNon-contrast computed tomographyStroke

Identifiers

PMID38427071
OpenAlexW4392358419

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.