Evidence map›Paper›PMID 38426887›Full record

ArticleRadiology. Imaging cancer2024

Characterizing Metabolic Heterogeneity of Hepatocellular Carcinoma with Hyperpolarized

Qianhui Dou, Aaron K Grant, Patricia Coutinto de Souza, Marwan Moussa, Imad Nasser, Muneeb Ahmed, Leo L Tsai

Open access · diamondAbstract read
In one paragraph

Article in Radiology. Imaging cancer, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
1.7field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 7 citations in OpenAlex.

  1. Proof-of-Concept Study of Hyperpolarized [1-Radiology. Imaging cancer · 2026
    Article
  2. Hyperpolarized [2-NMR in biomedicine · 2026
    Article
  3. Article
  4. Article
  5. Article
  6. Review
  7. Review
  8. Review
  9. HyperpolarizedRadiology. Imaging cancer · 2024
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Qianhui DouFrom the Departments of Radiology (Q.D., A.K.G., M.M., M.A., L.L.T.) and Pathology (I.N.), Beth Israel Deaconess Medical Center, Harvard Medical School, 330 Brookline Ave, ANSIN 230, Boston, MA 02215; and Merck & Co, Rahway, NJ (P.C.d.S.).ORCID 0000-0002-2418-4858
Aaron K GrantFrom the Departments of Radiology (Q.D., A.K.G., M.M., M.A., L.L.T.) and Pathology (I.N.), Beth Israel Deaconess Medical Center, Harvard Medical School, 330 Brookline Ave, ANSIN 230, Boston, MA 02215; and Merck & Co, Rahway, NJ (P.C.d.S.).ORCID 0000-0002-2605-8062
Patricia Coutinto de SouzaFrom the Departments of Radiology (Q.D., A.K.G., M.M., M.A., L.L.T.) and Pathology (I.N.), Beth Israel Deaconess Medical Center, Harvard Medical School, 330 Brookline Ave, ANSIN 230, Boston, MA 02215; and Merck & Co, Rahway, NJ (P.C.d.S.).
Marwan MoussaFrom the Departments of Radiology (Q.D., A.K.G., M.M., M.A., L.L.T.) and Pathology (I.N.), Beth Israel Deaconess Medical Center, Harvard Medical School, 330 Brookline Ave, ANSIN 230, Boston, MA 02215; and Merck & Co, Rahway, NJ (P.C.d.S.).ORCID 0000-0003-3462-7007
Imad NasserFrom the Departments of Radiology (Q.D., A.K.G., M.M., M.A., L.L.T.) and Pathology (I.N.), Beth Israel Deaconess Medical Center, Harvard Medical School, 330 Brookline Ave, ANSIN 230, Boston, MA 02215; and Merck & Co, Rahway, NJ (P.C.d.S.).ORCID 0000-0003-1228-2474
Muneeb AhmedFrom the Departments of Radiology (Q.D., A.K.G., M.M., M.A., L.L.T.) and Pathology (I.N.), Beth Israel Deaconess Medical Center, Harvard Medical School, 330 Brookline Ave, ANSIN 230, Boston, MA 02215; and Merck & Co, Rahway, NJ (P.C.d.S.).
Leo L TsaiFrom the Departments of Radiology (Q.D., A.K.G., M.M., M.A., L.L.T.) and Pathology (I.N.), Beth Israel Deaconess Medical Center, Harvard Medical School, 330 Brookline Ave, ANSIN 230, Boston, MA 02215; and Merck & Co, Rahway, NJ (P.C.d.S.).ORCID 0000-0001-6941-7443
Beth Israel Deaconess Medical Center · US

Funding

Hyperpolarized NMR for Studies of Cancer Therapies Targeting the Warburg EffectR01CA169470 · NCI · BETH ISRAEL DEACONESS MEDICAL CENTER · PI GRANT, AARON KEITH · 2013 to 2017
$1.8M
Pathway Specific Imaging in VHL Deficient Renal CancerR01CA152330 · NCI · BETH ISRAEL DEACONESS MEDICAL CENTER · PI SETH, PANKAJ K. · 2011 to 2014
$1.6M
Improved methods for perfusion imaging with hyperpolarized carbon-13R01EB028824 · NIBIB · BETH ISRAEL DEACONESS MEDICAL CENTER · PI GRANT, AARON KEITH · 2020 to 2023
$1.6M
NCI NIH HHS R01 CA152330NCI NIH HHS R01 CA169470NIBIB NIH HHS R01 EB028824
6 · The paper itself

Abstract

Purpose To characterize the metabolomic profiles of two hepatocellular carcinoma (HCC) rat models, track evolution of these profiles to a stimulated tumor state, and assess their effect on lactate flux with hyperpolarized (HP) carbon 13 (

Indexed as

Carcinoma, HepatocellularLiver NeoplasmsAnimalsFemaleLactatesMagnetic Resonance ImagingPyruvic AcidRatsRats, Inbred F344LactatesPyruvic AcidAbdomen/GIHepatocellular CarcinomaLiverMolecular Imaging-Probe DevelopmentOncology

Identifiers

PMID38426887
PMCPMC10988335
OpenAlexW4392387082

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.