ArticleAmerican journal of physiology. Heart and circulatory physiology2024
Beat-to-beat cardiac repolarization lability increases during hypoxemia and arousals in obstructive sleep apnea patients.
Article in American journal of physiology. Heart and circulatory physiology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed.
- Hypoxemia and arousals modulate cardiac responses to respiratory events in obstructive sleep apnea.Sleep · 2026Article
- Combined explainable deep learning model to predict pediatric sleep apnea from ECG and SpOMeasurement : journal of the International Measurement Confederation · 2026Article
- Beat-to-Beat QT Variability: A Population Study of the QT Variability Index Composition.Diagnostics (Basel, Switzerland) · 2026Article
- Intra-subject covariates of QT variability indices: influence of ECG noise.Frontiers in physiology · 2026Article
- Effect Heterogeneity of CPAP on MACE by Nocturnal Hypoxia Burden in Older Adults OSAS: A Propensity Score Matching Study.Clinical interventions in aging · 2026Article
- SleepECG-Net: Explainable Deep Learning Approach With ECG for Pediatric Sleep Apnea Diagnosis.IEEE journal of biomedical and health informatics · 2025Article
- Asthma and the risk of cardiac events among patients with long QT syndrome after age 40.Heart rhythm O2 · 2025Article
- Altered ventricular repolarisation dynamic: the missing link between obstructive sleep apnoea and sudden death?ERJ open research · 2024Article
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Authors and funding
14 authors.
Funding
Abstract
Obstructive sleep apnea (OSA) is associated with the progression of cardiovascular diseases, arrhythmias, and sudden cardiac death (SCD). However, the acute impacts of OSA and its consequences on heart function are not yet fully elucidated. We hypothesized that desaturation events acutely destabilize ventricular repolarization, and the presence of accompanying arousals magnifies this destabilization. Ventricular repolarization lability measures, comprising heart rate corrected QT (QTc), short-time-variability of QT (STVQT), and QT variability index (QTVI), were calculated before, during, and after 20,955 desaturations from lead II electrocardiography signals of 492 patients with suspected OSA (52% men). Variations in repolarization parameters were assessed during and after desaturations, both with and without accompanying arousals, and groupwise comparisons were performed based on desaturation duration and depth. Regression analyses were used to investigate the influence of confounding factors, comorbidities, and medications. The standard deviation (SD) of QT, mean QTc, SDQTc, and STVQT increased significantly (
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