Evidence map›Paper›PMID 38426788›Full record

Trial reportThe Journal of clinical endocrinology and metabolism2024

Association of Serum Phosphate, Calcium and Alkaline Phosphatase With Risk of Incident Fractures in Healthy Older Adults.

Sultana Monira Hussain, Ego Seeman, Hans G Schneider, Peter R Ebeling, Anna L Barker, Kevan Polkinghorne, Anne B Newman, Chenglong Yu, Paul Lacaze, Alice Owen and 7 more

Open access · hybridAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in The Journal of clinical endocrinology and metabolism, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
2.0field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 6 citations in OpenAlex.

  1. Trial
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors at 6 institutions in 2 countries.

Sultana Monira HussainSchool of Public Health and Preventive Medicine, Monash University, Melbourne, VIC 3004, Australia.ORCID 0000-0001-7894-2485
Ego SeemanDepartment of Medical Education, Melbourne Medical School, The University of Melbourne, Parkville, VIC 3010, Australia.
Hans G SchneiderAlfred Health, Monash University, Melbourne, VIC 3004, Australia.
Peter R EbelingSchool of Clinical Sciences, Monash University, Melbourne, VIC 3168, Australia.
Anna L BarkerSchool of Public Health and Preventive Medicine, Monash University, Melbourne, VIC 3004, Australia.
Kevan PolkinghorneSchool of Public Health and Preventive Medicine, Monash University, Melbourne, VIC 3004, Australia.
Anne B NewmanCenter for Aging and Population Health, Department of Epidemiology, University of Pittsburgh, Pittsburgh, PA 15260, USA.
Chenglong YuSchool of Public Health and Preventive Medicine, Monash University, Melbourne, VIC 3004, Australia.
Paul LacazeSchool of Public Health and Preventive Medicine, Monash University, Melbourne, VIC 3004, Australia.ORCID 0000-0002-0902-6798
Alice OwenSchool of Public Health and Preventive Medicine, Monash University, Melbourne, VIC 3004, Australia.ORCID 0000-0002-4807-6069
Cammie TranSchool of Public Health and Preventive Medicine, Monash University, Melbourne, VIC 3004, Australia.
Mark R NelsonMenzies Institute for Medical Research, University of Tasmania, Hobart, TAS 7000, Australia.
Robyn Lorraine WoodsSchool of Public Health and Preventive Medicine, Monash University, Melbourne, VIC 3004, Australia.
Bu B YeapSchool of Medicine, University of Western Australia, Perth, WA 6009, Australia.ORCID 0000-0002-7612-5892
David ClarkSchool of Public Health and Preventive Medicine, Monash University, Melbourne, VIC 3004, Australia.
Lawrence J BeilinSchool of Medicine, University of Western Australia, Perth, WA 6009, Australia.ORCID 0000-0003-4853-7360
John J McNeilSchool of Public Health and Preventive Medicine, Monash University, Melbourne, VIC 3004, Australia.
Monash University · AUAlfred Health · AUThe University of Melbourne · AUThe University of Western Australia · AUUniversity of Pittsburgh · USUniversity of Tasmania · AU

Funding

ASPirin in Reducing Events in the ElderlyU01AG029824 · NIA · HENNEPIN HEALTHCARE RESEARCH INSTITUTE · PI MCNEIL, JOHN JAMES, MURRAY, ANNE M · 2009 to 2018
$64.6M
Monash UniversityNational Health and Medical Research Council 334037National Institute on Aging and the National Cancer InstituteNIA NIH HHS U01 AG029824NIH HHS U01AG029824the NIHVictorian Cancer Agency
6 · The paper itself

Abstract

contextAging increases fracture risk through bone loss and microarchitecture deterioration due to an age-related imbalance in bone resorption and formation during bone remodeling.

objectiveWe examined the associations between levels of phosphate, calcium (Ca), and alkaline phosphatase (ALP), and fracture risk in initially healthy older individuals.

methodsA post hoc analysis of the Aspirin in Reducing Events in the Elderly (ASPREE) trial recruited 16 703 Australian participants aged 70 years and older and 2411 US participants aged 65 years and older. Analyses were conducted on ASPREE-Fracture substudy participants from Australia with serum calcium, phosphate, and ALP measurement. Fracture data were collected post randomization. Cox regression was used to calculate hazard ratios (HRs) and 95% CIs. Phosphate, Ca, and ALP were analyzed in deciles (D1-D10), with deciles 4 to 7 (31%-70%) as the reference category. Restricted cubic spline curves were used to identify nonlinear associations.

resultsOf the 9915 participants, 907 (9.2%) individuals had incident fractures recorded over 3.9 (SD 1.4) years. In the fully adjusted model, men in the top decile (D10) of phosphate had a 78% higher risk of incident fracture (HR 1.78; 95% CI, 1.25-2.54). No such association was observed for women (HR 1.09; 95% CI, 0.83-1.44). The population attributable fraction in men within the D10 phosphate category is 6.9%.

conclusionThis result confirms that high-normal serum phosphate levels are associated with increased fracture risk in older men.

Indexed as

Alkaline PhosphataseCalciumFractures, BonePhosphatesAgedAged, 80 and overAustraliaBiomarkersFemaleHumansIncidenceMaleRisk FactorsUnited StatesAlkaline PhosphataseBiomarkersCalciumPhosphatesalkaline phosphatasecalciumfracturesolder individualsphosphate

Identifiers

PMID38426788
PMCPMC11570385
OpenAlexW4392386695

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.