Evidence map›Paper›PMID 38426638›Full record

ReviewWiley interdisciplinary reviews. Nanomedicine and nanobiotechnology

Advances in nanoprobes for molecular MRI of Alzheimer's disease.

Parag Parekh, Andrew A Badachhape, Eric A Tanifum, Ananth V Annapragada, Ketan B Ghaghada

Abstract readReview
In one paragraph

Review in Wiley interdisciplinary reviews. Nanomedicine and nanobiotechnology. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Brain-Targeting siRNA Delivery to Tackle Alzheimer's Disease.Wiley interdisciplinary reviews. Nanomedicine and nanobiotechnology
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Parag ParekhDepartment of Radiology, Baylor College of Medicine, Houston, Texas, USA.
Andrew A BadachhapeDepartment of Radiology, Baylor College of Medicine, Houston, Texas, USA.
Eric A TanifumDepartment of Radiology, Baylor College of Medicine, Houston, Texas, USA.
Ananth V AnnapragadaDepartment of Radiology, Baylor College of Medicine, Houston, Texas, USA.
Ketan B GhaghadaDepartment of Radiology, Baylor College of Medicine, Houston, Texas, USA.ORCID 0000-0003-1012-8668

Funding

The PreVAIL-kIds Common ProtocolR33HD105593 · NICHD · BAYLOR COLLEGE OF MEDICINE · PI ALLEN, CARL E, ANNAPRAGADA, ANANTH V · 2023 to 2023
$6.3M
Targeting the immunosuppressive tumor microenvironment to enhance efficacy of radiotherapy and immuno-radiotherapy for oral cancerU01DE028233 · NIDCR · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI ANNAPRAGADA, ANANTH V, SIKORA, ANDREW · 2018 to 2022
$3.9M
Endothelial Dysfunction in the Development of Aortic Degeneration, Dissection, and RuptureR01HL159988 · NHLBI · BAYLOR COLLEGE OF MEDICINE · PI GHAGHADA, KETAN B, LEMAIRE, SCOTT A · 2022 to 2025
$2.6M
Molecular and Vascular MRI of Placenta AccretaR01HD094347 · NICHD · BAYLOR COLLEGE OF MEDICINE · PI ANNAPRAGADA, ANANTH V, FOX, KARIN ANNELIESE · 2018 to 2022
$2.2M
Cardiac photon counting CT and its application in studying interactions between Alzheimer's and heart diseaseRF1AG070149 · NIA · DUKE UNIVERSITY · PI BADEA, CRISTIAN T · 2021 to 2022
$2.1M
Personalizing Nanoparticle TherapyR01CA159042 · NCI · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI KUNDRA, VIKAS · 2011 to 2015
$1.6M
AICORE-kids: Artificial Intelligence COVID-19 Risk AssEssment for kidsR61HD105593 · NICHD · BAYLOR COLLEGE OF MEDICINE · PI ALLEN, CARL E, ANNAPRAGADA, ANANTH V · 2021 to 2022
$1.6M
American Heart Association-American Stroke Association 23IPA1054637NCI NIH HHS R01 CA159042NHLBI NIH HHS R01 HL159988NIA NIH HHS RF1 AG070149NICHD NIH HHS R01 HD094347NICHD NIH HHS R33 HD105593NICHD NIH HHS R61 HD105593NIDCR NIH HHS U01 DE028233NIH HHS R01CA159042NIH HHS R01HD094347NIH HHS R01HL159988NIH HHS R33HD105593NIH HHS R61HD105593NIH HHS RF1AG070149NIH HHS U01DE028233
6 · The paper itself

Abstract

Alzheimer's disease is the most common cause of dementia and a leading cause of mortality in the elderly population. Diagnosis of Alzheimer's disease has traditionally relied on evaluation of clinical symptoms for cognitive impairment with a definitive diagnosis requiring post-mortem demonstration of neuropathology. However, advances in disease pathogenesis have revealed that patients exhibit Alzheimer's disease pathology several decades before the manifestation of clinical symptoms. Magnetic resonance imaging (MRI) plays an important role in the management of patients with Alzheimer's disease. The clinical availability of molecular MRI (mMRI) contrast agents can revolutionize the diagnosis of Alzheimer's disease. In this article, we review advances in nanoparticle contrast agents, also referred to as nanoprobes, for mMRI of Alzheimer's disease. This article is categorized under: Diagnostic Tools > In Vivo Nanodiagnostics and Imaging Therapeutic Approaches and Drug Discovery > Nanomedicine for Neurological Disease.

Indexed as

Alzheimer DiseaseCognitive DysfunctionAgedBrainContrast MediaHumansMagnetic Resonance ImagingPositron-Emission TomographyContrast MediaAlzheimer's diseaseamyloidmagnetic resonance imagingmicrogliamolecular imagingnanoparticle contrast agentnanoprobesneurodegenerationneuroinflammationneurontau

Identifiers

PMID38426638
PMCPMC10983770

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.