Evidence map›Paper›PMID 38426490›Full record

ArticleThe Journal of clinical investigation2024

G protein-coupled receptors: from radioligand binding to cellular signaling.

Howard A Rockman, Robert J Lefkowitz

Abstract read
In one paragraph

Article in The Journal of clinical investigation, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

  1. Article
  2. Review
  3. GPCR Biased Signaling in Cancer.Handbook of experimental pharmacology · 2026
    Review
  4. Article
  5. Discovering Key Activation Hotspots in the MJournal of the American Chemical Society · 2025
    Article
  6. Article
  7. A method for rapid and reliable quantification of VEGF-cell binding activity.Biochemical and biophysical research communications · 2024
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Howard A RockmanDepartment of Medicine.
Robert J LefkowitzDepartment of Medicine.

Funding

Molecular Regulation of Cardiovascular 7 TM ReceptorsR01HL016037 · NHLBI · DUKE UNIVERSITY · PI ROBERT J LEFKOWITZ · 1985 to 2026
$14.5M
MECHANISMS OF MALADAPTATION IN HEART FAILURER01HL056687 · NHLBI · UNIVERSITY OF NORTH CAROLINA CHAPEL HILL · PI Howard A Rockman · 1996 to 2026
$12.3M
NHLBI NIH HHS R01 HL016037NHLBI NIH HHS R01 HL056687
6 · The paper itself

Abstract

Radioligand binding techniques facilitated the identification and study of G-protein coupled receptors that now represent the largest class of targets for therapeutic drugs.

Indexed as

Receptors, G-Protein-CoupledRadioligand AssayReceptors, G-Protein-Coupled

Identifiers

PMID38426490
PMCPMC10904040

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.