Evidence map›Paper›PMID 38426371›Full record

ArticleAlzheimer's & dementia : the journal of the Alzheimer's Association2024

Genetic diversity promotes resilience in a mouse model of Alzheimer's disease.

Neelakshi Soni, Lindsay A Hohsfield, Kristine M Tran, Shimako Kawauchi, Amber Walker, Dominic Javonillo, Jimmy Phan, Dina Matheos, Celia Da Cunha, Asli Uyar and 12 more

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Alzheimer's & dementia : the journal of the Alzheimer's Association, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
5.2field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 16 citations in OpenAlex.

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  12. Genetic diversity promotes resilience in a mouse model of Alzheimer's disease.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2024
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

22 authors at 3 institutions in 1 country.

Neelakshi SoniDepartment of Neurobiology and Behavior, University of California, Irvine, California, USA.
Lindsay A HohsfieldDepartment of Neurobiology and Behavior, University of California, Irvine, California, USA.
Kristine M TranDepartment of Neurobiology and Behavior, University of California, Irvine, California, USA.
Shimako KawauchiInstitute for Memory Impairments and Neurological Disorders, University of California, Irvine, California, USA.
Amber WalkerInstitute for Memory Impairments and Neurological Disorders, University of California, Irvine, California, USA.
Dominic JavonilloDepartment of Neurobiology and Behavior, University of California, Irvine, California, USA.
Jimmy PhanInstitute for Memory Impairments and Neurological Disorders, University of California, Irvine, California, USA.
Dina MatheosDepartment of Neurobiology and Behavior, University of California, Irvine, California, USA.
Celia Da CunhaInstitute for Memory Impairments and Neurological Disorders, University of California, Irvine, California, USA.
Asli UyarThe Jackson Laboratory, Bar Harbor, Maine, USA.
Giedre MilinkeviciuteInstitute for Memory Impairments and Neurological Disorders, University of California, Irvine, California, USA.
Angela Gomez-ArboledasInstitute for Memory Impairments and Neurological Disorders, University of California, Irvine, California, USA.
Katelynn TranInstitute for Memory Impairments and Neurological Disorders, University of California, Irvine, California, USA.
Catherine C KaczorowskiDepartment of Neurology, University of Michigan, Ann Arbor, Michigan, USA.
Marcelo A WoodDepartment of Neurobiology and Behavior, University of California, Irvine, California, USA.
Andrea J TennerDepartment of Neurobiology and Behavior, University of California, Irvine, California, USA.
Frank M LaFerlaDepartment of Neurobiology and Behavior, University of California, Irvine, California, USA.
Gregory W CarterThe Jackson Laboratory, Bar Harbor, Maine, USA.
Ali MortazaviInstitute for Memory Impairments and Neurological Disorders, University of California, Irvine, California, USA.
Vivek SwarupDepartment of Neurobiology and Behavior, University of California, Irvine, California, USA.
Grant R MacGregorTransgenic Mouse Facility, ULAR, Office of Research, University of California, Irvine, California, USA.
Kim N GreenDepartment of Neurobiology and Behavior, University of California, Irvine, California, USA.
University of California, Irvine · USJackson Laboratory · USUniversity of Michigan–Ann Arbor · US

Funding

UC Irvine MODEL-ADU54AG054349 · NIA · UNIVERSITY OF CALIFORNIA-IRVINE · PI Kim Green, FRANK M LAFERLA · 2017 to 2026
$71.9M
Univ.of Calif., Irvine Cancer Center Support GrantP30CA062203 · NCI · UNIVERSITY OF CALIFORNIA-IRVINE · PI Melanie Funes · 1994 to 2026
$57.9M
Training in the Neurobiology of Aging and Alzheimers DiseaseT32AG000096 · NIA · UNIVERSITY OF CALIFORNIA-IRVINE · PI VIVEK SWARUP, Craig E Stark · 1985 to 2026
$9.6M
NCI NIH HHS P30 CA062203NIA NIH HHS T32 AG000096NIA NIH HHS U54 AG054349
6 · The paper itself

Abstract

introductionAlzheimer's disease (AD) is a neurodegenerative disorder with multifactorial etiology, including genetic factors that play a significant role in disease risk and resilience. However, the role of genetic diversity in preclinical AD studies has received limited attention.

methodsWe crossed five Collaborative Cross strains with 5xFAD C57BL/6J female mice to generate F1 mice with and without the 5xFAD transgene. Amyloid plaque pathology, microglial and astrocytic responses, neurofilament light chain levels, and gene expression were assessed at various ages.

resultsGenetic diversity significantly impacts AD-related pathology. Hybrid strains showed resistance to amyloid plaque formation and neuronal damage. Transcriptome diversity was maintained across ages and sexes, with observable strain-specific variations in AD-related phenotypes. Comparative gene expression analysis indicated correlations between mouse strains and human AD. DISCUSSION: Increasing genetic diversity promotes resilience to AD-related pathogenesis, relative to an inbred C57BL/6J background, reinforcing the importance of genetic diversity in uncovering resilience in the development of AD. HIGHLIGHTS: Genetic diversity's impact on AD in mice was explored. Diverse F1 mouse strains were used for AD study, via the Collaborative Cross. Strain-specific variations in AD pathology, glia, and transcription were found. Strains resilient to plaque formation and plasma neurofilament light chain (NfL) increases were identified. Correlations with human AD transcriptomics were observed.

Indexed as

Alzheimer DiseaseResilience, PsychologicalAmyloid beta-PeptidesAnimalsDisease Models, AnimalFemaleGenetic VariationHumansMiceMice, Inbred C57BLMice, TransgenicMicrogliaPlaque, AmyloidAmyloid beta-Peptides5xFADAlzheimer's diseaseamyloidastrocytescollaborative cross micegenetic diversitymicroglianeurofilament light chainresilience

Identifiers

PMID38426371
PMCPMC11032575
OpenAlexW4392355476

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.