Evidence map›Paper›PMID 38426363›Full record

ArticleRheumatology (Oxford, England)2024

A simple, clinically usable whole-body MRI system of joint assessment in adolescents and young people with juvenile idiopathic arthritis.

Varvara Choida, Timothy J P Bray, Niels van Vucht, Maaz Ali Abbasi, Alan P Bainbridge, Thomas Parry, Sue Mallett, Coziana Ciurtin, Margaret A Hall-Craggs

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Rheumatology (Oxford, England), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
3.2field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 7 citations in OpenAlex.

  1. Imaging in Juvenile Idiopathic Arthritis: A Comprehensive Review.The Indian journal of radiology & imaging · 2026
    Article
  2. Review
  3. Whole-body MRI in arthritis.Skeletal radiology · 2025
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 1 country.

Varvara ChoidaCentre for Medical Imaging, University College London, London, UK.ORCID 0000-0003-2418-9648
Timothy J P BrayCentre for Medical Imaging, University College London, London, UK.
Niels van VuchtDepartment of Imaging, University College London Hospitals NHS Foundation Trust, London, UK.
Maaz Ali AbbasiDepartment of Imaging, University College London Hospitals NHS Foundation Trust, London, UK.
Alan P BainbridgeCentre for Medical Imaging, University College London, London, UK.
Thomas ParryCentre for Medical Imaging, University College London, London, UK.
Sue MallettCentre for Medical Imaging, University College London, London, UK.
Coziana CiurtinDivision of Medicine, Centre for Adolescent Rheumatology, University College London, UK.ORCID 0000-0002-8911-4113
Margaret A Hall-CraggsCentre for Medical Imaging, University College London, London, UK.
University College London Hospitals NHS Foundation Trust · GBUniversity College London · GBUniversity College Hospital · GB

Funding

Action Medical Research and Humanimal TrustBiomedical Research Centre BRC 525 III/CC 101350British Society of Rheumatology 3220566Centre for Adolescent Rheumatology 21593Centre of ExcellenceDepartment of HealthNational Health ServiceNational Institute for Health ResearchNIHRThe Albert Gubay Foundation GN 2697UCLHUniversity College London Hospitals
6 · The paper itself

Abstract

objectivesTo introduce and evaluate a simple method for assessing joint inflammation and structural damage on whole-body MRI (WBMRI) in juvenile idiopathic arthritis (JIA), which is usable in clinical practice.

methodsThe proposed system utilizes post-contrast Dixon WBMRI scans. Joints are assessed for synovitis (grade 0-2) and structural damage (present/absent) at 81 sites. The synovitis grading is based on features including above-normal intensity synovial enhancement, synovial hypertrophy, joint effusion, subarticular bone marrow oedema and peri-articular soft tissue oedema.This system was evaluated in a prospective study of 60 young people (47 patients with JIA and 13 controls with non-inflammatory musculoskeletal pain) who underwent a WBMRI. Three readers (blinded to diagnosis) independently reviewed all images and re-reviewed 20 individual scans. The intra- and inter-reader overall agreement (OA) and the intra- and inter-reader Gwet's agreement coefficients 2 (GAC2) were measured for the detection of a) participants with ≥1 joint with inflammation or structural damage and b) joint inflammation or structural damage for each joint.

resultsThe inter-reader OA for detecting patients with ≥1 joint with inflammation, defined as grade 2 synovitis (G2), and ≥1 joint with structural damage were 80% and 73%, respectively. The intra-reader OA for readers 1-3 was 80-90% and 75-90%, respectively. The inter-reader OA and GAC2 for joint inflammation (G2) at each joint were both ≥85% for all joints but were lower if grade 1 synovitis was included as positive.

conclusionThe intra- and inter-reader agreements of this WBMRI assessment system are adequate for assessing objective joint inflammation and damage in JIA.

Indexed as

Arthritis, JuvenileMagnetic Resonance ImagingSynovitisWhole Body ImagingAdolescentCase-Control StudiesChildFemaleHumansJointsMaleObserver VariationProspective StudiesReproducibility of ResultsSeverity of Illness IndexYoung AdultactivityagreementDixonJIAjointMRIreliabilityscoringsynovitiswhole-body

Identifiers

PMID38426363
PMCPMC11381680
OpenAlexW4392351881

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.