Evidence map›Paper›PMID 38426275›Full record

ArticleHaematologica2024

Efficacy of DYRK1A inhibitors in novel models of Down syndrome acute lymphoblastic leukemia.

Shannon L Carey-Smith, Maryam H Simad, Kunjal Panchal, Carlos Aya-Bonilla, Hannah Smolders, Sang Lin, Jesse D Armitage, Vivien T Nguyen, Kathryn Bentley, Jette Ford and 13 more

Abstract readLetter
PubMed Full text at PMC Publisher
In one paragraph

Article in Haematologica, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
  4. Article
  5. Novel Thiazole-Fused [4,5-Pharmaceuticals (Basel, Switzerland) · 2024
    Article
  6. Review
  7. Aberrant stem cell and developmental programs in pediatric leukemia.Frontiers in cell and developmental biology · 2024
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

23 authors.

Shannon L Carey-SmithTelethon Kids Cancer Centre, Telethon Kids Institute, Perth, WA, Australia; Curtin Medical School, Curtin University, Perth, WA.
Maryam H SimadTelethon Kids Cancer Centre, Telethon Kids Institute, Perth, WA.
Kunjal PanchalTelethon Kids Cancer Centre, Telethon Kids Institute, Perth, WA, Australia; Curtin Medical School, Curtin University, Perth, WA.
Carlos Aya-BonillaTelethon Kids Cancer Centre, Telethon Kids Institute, Perth, WA.
Hannah SmoldersTelethon Kids Cancer Centre, Telethon Kids Institute, Perth, WA.
Sang LinTelethon Kids Cancer Centre, Telethon Kids Institute, Perth, WA.
Jesse D ArmitageTelethon Kids Cancer Centre, Telethon Kids Institute, Perth, WA.
Vivien T NguyenTelethon Kids Cancer Centre, Telethon Kids Institute, Perth, WA.
Kathryn BentleyTelethon Kids Cancer Centre, Telethon Kids Institute, Perth, WA.
Jette FordTelethon Kids Cancer Centre, Telethon Kids Institute, Perth, WA.
Sajla SinghTelethon Kids Cancer Centre, Telethon Kids Institute, Perth, WA.
Joyce OommenTelethon Kids Cancer Centre, Telethon Kids Institute, Perth, WA.
Anouchka P LaurentU1170 INSERM, Gustave Roussy, Villejuif.
Thomas MercherU1170 INSERM, Gustave Roussy, Villejuif.
John D CrispinoDepartment of Hematology, St Jude Children's Hospital, Memphis, TN.
Andrew P MontgomerySchool of Chemistry, University of Sydney, NSW.
Michael KassiouSchool of Chemistry, University of Sydney, NSW.
Thierry BessonUniversity Rouen Normandie, INSA Rouen Normandie, CNRS, COBRA UMR 6014, 76000.
Emmanuel DeauPerha Pharmaceuticals, Perharidy Peninsula, Roscoff.
Laurent MeijerPerha Pharmaceuticals, Perharidy Peninsula, Roscoff.
Laurence C CheungTelethon Kids Cancer Centre, Telethon Kids Institute, Perth, WA, Australia; Curtin Medical School, Curtin University, Perth, WA, Australia; Curtin Health Innovation Research Institute, Curtin University, Perth, WA.
Rishi S KotechaTelethon Kids Cancer Centre, Telethon Kids Institute, Perth, WA, Australia; Curtin Medical School, Curtin University, Perth, WA, Australia; Department of Clinical Haematology, Oncology, Blood and Marrow Transplantation, Perth Children's Hospital, Perth, WA, Australia; University of Western Australia, Perth, WA.
Sébastien MalingeTelethon Kids Cancer Centre, Telethon Kids Institute, Perth, WA, Australia; Curtin Medical School, Curtin University, Perth, WA, Australia; University of Western Australia, Perth, WA. sebastien.malinge@telethonkids.org.au.

Funding

Medical Research Council APP1154692
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

Down SyndromeDyrk KinasesPrecursor Cell Lymphoblastic Leukemia-LymphomaProtein Kinase InhibitorsProtein Serine-Threonine KinasesProtein-Tyrosine KinasesAnimalsDisease Models, AnimalHumansMiceDyrk KinasesProtein Kinase InhibitorsProtein Serine-Threonine KinasesProtein-Tyrosine Kinases

Identifiers

PMID38426275
PMCPMC11215345

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.