Evidence map›Paper›PMID 38426133›Full record

ArticlePeerJ2024

Impact of coexisting type 2 diabetes mellitus on the urinary microbiota of kidney stone patients.

Xiang Li, Yifan Tang, Zhenyi Xu, Hao Lin, Shichao Wei, Jiayi Sheng, Lei Hu, Shiyu Wang, Yu Zhao, Zhi Li and 6 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in PeerJ, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed, 1 pooled it
1.3field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 synthesis or guideline pooled it, 3 citations in OpenAlex.

  1. Pooled it
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors at 6 institutions in 1 country.

Xiang Li *Department of Urology, The First Affiliated Hospital of Soochow University, Suzhou, China.
Yifan Tang *Department of Urology, Affiliated Wuxi No. 2 Hospital, Nanjing Medical University, Wuxi, China.
Zhenyi XuDepartment of Urology, Affiliated Wuxi No. 2 Hospital, Nanjing Medical University, Wuxi, China.
Hao LinDepartment of Urology, Affiliated Wuxi No. 2 Hospital, Nanjing Medical University, Wuxi, China.
Shichao WeiDepartment of Urology, Affiliated Wuxi No. 2 Hospital, Nanjing Medical University, Wuxi, China.
Jiayi ShengDepartment of Urology, Affiliated Wuxi No. 2 Hospital, Nanjing Medical University, Wuxi, China.
Lei HuDepartment of Urology, Affiliated Wuxi No. 2 Hospital, Nanjing Medical University, Wuxi, China.
Shiyu WangWuxi School of Medicine, Jiangnan University, Wuxi, China.
Yu ZhaoWuxi School of Medicine, Jiangnan University, Wuxi, China.
Zhi LiWuxi School of Medicine, Jiangnan University, Wuxi, China.
Chaowei FuWuxi School of Medicine, Jiangnan University, Wuxi, China.
Yifeng GuCollaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, School of Medicine, The First Affiliated Hospital, Zhejiang University, Hangzhou, China.
Qun WeiDepartment of Surgical Oncology, Institute of Clinical Medicine, Sir Run Run Shaw Hospital, School of Medicine, Zhejiang University, Hangzhou, China.
Fengping LiuWuxi School of Medicine, Jiangnan University, Wuxi, China.
Ninghan FengDepartment of Urology, Affiliated Wuxi No. 2 Hospital, Nanjing Medical University, Wuxi, China.
Weiguo ChenDepartment of Urology, The First Affiliated Hospital of Soochow University, Suzhou, China.
Jiangnan University · CNNanjing Medical University · CNWuxi No.2 People's Hospital · CNFirst Affiliated Hospital of Soochow University · CNFirst Affiliated Hospital Zhejiang University · CNSir Run Run Shaw Hospital · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Objectives: Type 2 diabetes mellitus (T2DM) commonly complicates kidney stone disease (KSD). Our objective is to investigate the variations in the urinary microbiota between individuals with KSD alone and those with KSD plus T2DM. This exploration could have implications for disease diagnosis and treatment strategies. Methods: During lithotripsy, a ureterscope was employed, and 1 mL of urine was collected from the renal pelvis after bladder disinfection. Sequencing targeting the V3-V4 hypervariable region was performed using the 16S rRNA and Illumina Novaseq platform. Results: The Shannon index showed a significant decrease in the KSD plus T2DM group compared to the KSD-only group (false discovery rate = 0.041). Principal Coordinate Analysis (PCoA) demonstrated a distinct bacterial community in the KSD plus T2DM group compared to the KSD-only group (false discovery rate = 0.027). The abundance of Conclusions: The urinary microbiota in the renal pelvis exhibits differences between patients with KSD plus T2DM and those with KSD alone. Further studies employing animal models are necessary to validate these distinctions, potentially paving the way for therapeutic developments based on the urinary microbiota.

Indexed as

Diabetes Mellitus, Type 2Kidney CalculiMicrobiotaBacteriaHumansRNA, Ribosomal, 16SRNA, Ribosomal, 16SKidney stoneMetabolicRenal pelvisType 2 diabetic mellitusUrinary microbiota

Identifiers

PMID38426133
PMCPMC10903351
OpenAlexW4392159887

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.