Evidence map›Paper›PMID 38426099›Full record

ArticleFrontiers in immunology2024

Isolation and expansion of pure and functional γδ T cells.

Tamara Verkerk, Anouk T Pappot, Tineke Jorritsma, Lisa A King, Mariël C Duurland, Robbert M Spaapen, S Marieke van Ham

Open access · goldAbstract read
In one paragraph

Article in Frontiers in immunology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
3.4field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 14 citations in OpenAlex.

  1. Article
  2. Viscoelastic Niches Shape γδ T-Cell Phenotype and Effector Function.bioRxiv : the preprint server for biology · 2026
    Article
  3. Article
  4. Efficient multiplex non-viral engineering and expansion of polyclonal γδ CAR-T cells for immunotherapy.Molecular therapy : the journal of the American Society of Gene Therapy · 2026
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 4 institutions in 1 country.

Tamara VerkerkDepartment of Immunopathology, Sanquin Research, Amsterdam, Netherlands.
Anouk T PappotDepartment of Immunopathology, Sanquin Research, Amsterdam, Netherlands.
Tineke JorritsmaDepartment of Immunopathology, Sanquin Research, Amsterdam, Netherlands.
Lisa A KingAmsterdam Institute for Infection and Immunity, Amsterdam, Netherlands.
Mariël C DuurlandDepartment of Immunopathology, Sanquin Research, Amsterdam, Netherlands.
Robbert M SpaapenDepartment of Immunopathology, Sanquin Research, Amsterdam, Netherlands.
S Marieke van HamDepartment of Immunopathology, Sanquin Research, Amsterdam, Netherlands.
University of Amsterdam · NLSanquin · NLAmsterdam University Medical Centers · NLCancer Center Amsterdam

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

γδ T cells are important components of the immune system due to their ability to elicit a fast and strong response against infected and transformed cells. Because they can specifically and effectively kill target cells in an MHC independent fashion, there is great interest to utilize these cells in anti-tumor therapies where antigen presentation may be hampered. Since only a small fraction of T cells in the blood or tumor tissue are γδ T cells, they require extensive expansion to allow for fundamental, preclinical and

Indexed as

CytokinesReceptors, Antigen, T-Cell, gamma-deltaCell Line, TumorCytokinesReceptors, Antigen, T-Cell, gamma-deltafunctional validationgamma delta (γδ) T cellshigh purityisolation and expansionmethod comparison

Identifiers

PMID38426099
PMCPMC10902048
OpenAlexW4391841921

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.