ReviewFrontiers in pain research (Lausanne, Switzerland)2024
Biomarkers for assessing pain and pain relief in the neonatal intensive care unit.
Review in Frontiers in pain research (Lausanne, Switzerland), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
11 citing papers in PubMed, 1 synthesis or guideline pooled it, 18 citations in OpenAlex.
- Assessment of cortisol as a neonatal pain biomarker in the application of non-pharmacological analgesia therapies: systematic review and meta-analysis.BMC pediatrics · 2025Pooled it
- Trial
- Utilization of electrodermal activity in nursing research: A mapping review.Japan journal of nursing science : JJNS · 2026Review
- Evaluation of Pain in Infants of the First 100 Days of Age With Artificial Intelligence Techniques.Journal of evaluation in clinical practice · 2026Article
- Stress exposure, stress responses, and short-term outcomes in very preterm neonates: a national cohort study.European journal of pediatrics · 2026Observational
- Physiological correlates of pain in preterm infants: evidence from a meta-analytic approach.Frontiers in pediatrics · 2026Review
- The effect of tactile versus auditory stimulation on reducing pain associated with invasive procedures among preterm neonates at NICUs.BMC pediatrics · 2025Article
- Comparing the effects of vein finder technology and traditional venipuncture on pain and behavioural states in preterm infants: a quasi-experimental study.BMJ paediatrics open · 2025Article
- Pain management in preterm infants with necrotizing enterocolitis: an international expert consensus statement.European journal of pediatrics · 2025Article
- Impact of sociodemographic status of countries on neonatal analgosedation management.Pediatric research · 2024Article
- Why Do Nurses Fail to Implement Pain Assessment Instruments for Hospitalized Infants?Iranian journal of nursing and midwifery researchArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Newborns admitted to the neonatal intensive care unit (NICU) regularly undergo painful procedures and may face various painful conditions such as postoperative pain. Optimal management of pain in these vulnerable preterm and term born neonates is crucial to ensure their comfort and prevent negative consequences of neonatal pain. This entails accurate and timely identification of pain, non-pharmacological pain treatment and if needed administration of analgesic therapy, evaluation of treatment effectiveness, and monitoring of adverse effects. Despite the widely recognized importance of pain management, pain assessment in neonates has thus far proven to be a challenge. As self-report, the gold standard for pain assessment, is not possible in neonates, other methods are needed. Several observational pain scales have been developed, but these often rely on snapshot and largely subjective observations and may fail to capture pain in certain conditions. Incorporation of biomarkers alongside observational pain scores holds promise in enhancing pain assessment and, by extension, optimizing pain treatment and neonatal outcomes. This review explores the possibilities of integrating biomarkers in pain assessment in the NICU.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.