Evidence map›Paper›PMID 38425781›Full record

ArticleBioinformatics advances2024

ExpoSeq: simplified analysis of high-throughput sequencing data from antibody discovery campaigns.

Christoffer V Sørensen, Nils Hofmann, Puneet Rawat, Frederik V Sørensen, Anne Ljungars, Victor Greiff, Andreas H Laustsen, Timothy P Jenkins

Abstract read
In one paragraph

Article in Bioinformatics advances, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. mAbs · 2026
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Christoffer V SørensenDepartment of Biotechnology and Biomedicine, Technical University of Denmark, DK-2800 Kongens Lyngby, Denmark.ORCID https://orcid.org/0000-0001-7727-936X
Nils HofmannDepartment of Biotechnology and Biomedicine, Technical University of Denmark, DK-2800 Kongens Lyngby, Denmark.ORCID https://orcid.org/0009-0006-4639-6161
Puneet RawatDepartment of Immunology, University of Oslo and Oslo University Hospital, NO-0316 Oslo, Norway.ORCID https://orcid.org/0000-0002-3822-8081
Frederik V SørensenBornerups A/S, DK-7700 Thisted, Denmark.
Anne LjungarsDepartment of Biotechnology and Biomedicine, Technical University of Denmark, DK-2800 Kongens Lyngby, Denmark.ORCID https://orcid.org/0000-0002-2158-0601
Victor GreiffDepartment of Immunology, University of Oslo and Oslo University Hospital, NO-0316 Oslo, Norway.ORCID https://orcid.org/0000-0003-2622-5032
Andreas H LaustsenDepartment of Biotechnology and Biomedicine, Technical University of Denmark, DK-2800 Kongens Lyngby, Denmark.ORCID https://orcid.org/0000-0001-6918-5574
Timothy P JenkinsDepartment of Biotechnology and Biomedicine, Technical University of Denmark, DK-2800 Kongens Lyngby, Denmark.ORCID https://orcid.org/0000-0003-2979-5663

Funding

European Research Council 850974Wellcome Trust 221702
6 · The paper itself

Abstract

Summary: High-throughput sequencing (HTS) offers a modern, fast, and explorative solution to unveil the full potential of display techniques, like antibody phage display, in molecular biology. However, a significant challenge lies in the processing and analysis of such data. Furthermore, there is a notable absence of open-access user-friendly software tools that can be utilized by scientists lacking programming expertise. Here, we present ExpoSeq as an easy-to-use tool to explore, process, and visualize HTS data from antibody discovery campaigns like an expert while only requiring a beginner's knowledge. Availability and implementation: The pipeline is distributed via GitHub and PyPI, and it can either be installed as a package with pip or the user can choose to clone the repository.

Identifiers

PMID38425781
PMCPMC10902677

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.