Evidence map›Paper›PMID 38425576›Full record

ArticleBrain communications2023

Epilepsy and sudden unexpected death in epilepsy in a mouse model of human

Chunling Chen, Julie Ziobro, Larissa Robinson-Cooper, Samantha L Hodges, Yan Chen, Nnamdi Edokobi, Luis Lopez-Santiago, Karl Habig, Chloe Moore, Joe Minton and 7 more

Erratum issuedOpen access · goldAbstract read
In one paragraph

Article in Brain communications, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
4.4field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 14 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Transcriptomic Profiling of Zebrafish Mutant forInternational journal of molecular sciences · 2025
    Article
  6. Gene therapies alleviate absence epilepsy associated withbioRxiv : the preprint server for biology · 2025
    Article
  7. Article
  8. Review
  9. Article
  10. Article
  11. Article
  12. Brain communications · 2024
    Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

17 authors at 3 institutions in 3 countries.

Chunling ChenDepartment of Pharmacology, University of Michigan Medical School, Ann Arbor, MI 48109, USA.
Julie ZiobroDepartment of Pediatrics, University of Michigan Medical School, Ann Arbor, MI 48109, USA.
Larissa Robinson-CooperDepartment of Pharmacology, University of Michigan Medical School, Ann Arbor, MI 48109, USA.
Samantha L HodgesDepartment of Pharmacology, University of Michigan Medical School, Ann Arbor, MI 48109, USA.
Yan ChenDepartment of Pharmacology, University of Michigan Medical School, Ann Arbor, MI 48109, USA.
Nnamdi EdokobiDepartment of Pharmacology, University of Michigan Medical School, Ann Arbor, MI 48109, USA.
Luis Lopez-SantiagoDepartment of Pharmacology, University of Michigan Medical School, Ann Arbor, MI 48109, USA.
Karl HabigDepartment of Pharmacology, University of Michigan Medical School, Ann Arbor, MI 48109, USA.
Chloe MooreDepartment of Pharmacology, University of Michigan Medical School, Ann Arbor, MI 48109, USA.
Joe MintonDepartment of Pharmacology, University of Michigan Medical School, Ann Arbor, MI 48109, USA.
Sabrina BramsonDepartment of Pharmacology, University of Michigan Medical School, Ann Arbor, MI 48109, USA.
Caroline ScheuingDepartment of Pharmacology, University of Michigan Medical School, Ann Arbor, MI 48109, USA.
Noor DaddoDepartment of Neurology, University of Michigan Medical School, Ann Arbor, MI 48109, USA.
Katalin ŠtěrbováDepartment of Pediatric Neurology, Charles University and Motol Hospital, V Úvalu 84, 150 06 Prague 5, Czech Republic.
Sarah WeckhuysenApplied & Translational Neurogenomics Group, VIB Center for Molecular Neurology, VIB, Universiteitsplein 1 B-2610 Antwerpen, Belgium.ORCID https://orcid.org/0000-0003-2878-1147
Jack M ParentDepartment of Neurology, University of Michigan Medical School, Ann Arbor, MI 48109, USA.
Lori L IsomDepartment of Pharmacology, University of Michigan Medical School, Ann Arbor, MI 48109, USA.ORCID https://orcid.org/0000-0002-9479-6729
University of Michigan · USCharles University · CZUniversity of Antwerp · BE

Funding

Role of SCN1B in Inherited EpilepsyR37NS076752 · NINDS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI ISOM, LORI L. · 2017 to 2023
$4.8M
Training Program in Translational Cardiovascular Research and EntrepreneurshipT32HL125242 · NHLBI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI MICHELE, DANIEL E · 2015 to 2024
$1.9M
NHLBI NIH HHS T32 HL125242NINDS NIH HHS R37 NS076752
6 · The paper itself

Abstract

Voltage-gated sodium channel β1 subunits are essential proteins that regulate excitability. They modulate sodium and potassium currents, function as cell adhesion molecules and regulate gene transcription following regulated intramembrane proteolysis. Biallelic pathogenic variants in

Indexed as

developmental and epileptic encephalopathyseizuresodium channelSUDEPβ subunit

Identifiers

PMID38425576
PMCPMC10903178
OpenAlexW4387768751

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.