Evidence map›Paper›PMID 38425390›Full record

ArticleWorld journal of gastrointestinal oncology2024

Prognostic nutritional index in predicting survival of patients with gastric or gastroesophageal junction adenocarcinoma: A systematic review.

Stylianos Fiflis, Grigorios Christodoulidis, Menelaos Papakonstantinou, Alexandros Giakoustidis, Stergos Koukias, Paraskevi Roussos, Marina Nektaria Kouliou, Konstantinos Eleftherios Koumarelas, Dimitrios Giakoustidis

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Article in World journal of gastrointestinal oncology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

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0cells of the map it votes in
3citing papers in PubMed
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1 · What the graph read from it

What it found

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2 · The registry

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3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

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4 · The record

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5 · Who and what money

Authors and funding

9 authors.

Stylianos FiflisFirst Department of Surgery, General Hospital Papageorgiou, Thessaloniki 56429, Greece.
Grigorios ChristodoulidisDepartment of General Surgery, University Hospital of Larissa, Larissa 41110, Greece. gregsurg@yahoo.gr.
Menelaos PapakonstantinouFirst Department of Surgery, General Hospital Papageorgiou, Thessaloniki 56429, Greece.
Alexandros GiakoustidisFirst Department of Surgery, General Hospital Papageorgiou, Thessaloniki 56429, Greece.
Stergos KoukiasFirst Department of Surgery, General Hospital Papageorgiou, Thessaloniki 56429, Greece.
Paraskevi RoussosFirst Department of Surgery, General Hospital Papageorgiou, Thessaloniki 56429, Greece.
Marina Nektaria KouliouDepartment of General Surgery, University Hospital of Larissa, Larissa 41110, Greece.
Konstantinos Eleftherios KoumarelasDepartment of General Surgery, University Hospital of Larissa, Larissa 41110, Greece.
Dimitrios GiakoustidisFirst Department of Surgery, General Hospital Papageorgiou, Thessaloniki 56429, Greece.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundGastric cancer is the third most common cause of cancer related death worldwide. Surgery with or without chemotherapy is the most common approach with curative intent; however, the prognosis is poor as mortality rates remain high. Several indexes have been proposed in the past few years in order to estimate the survival of patients undergoing gastrectomy. The preoperative nutritional status of gastric cancer patients has recently gained attention as a factor that could affect the postoperative course and various indexes have been developed. The aim of this systematic review was to assess the role of the prognostic nutritional index (PNI) in predicting the survival of patients with gastric or gastroesophageal adenocarcinoma who underwent gastrectomy with curative intent.

aimTo investigate the role of PNI in predicting the survival of patients with gastric or gastroesophageal junction adenocarcinoma.

methodsA thorough literature search of PubMed and the Cochrane library was performed for studies comparing the overall survival (OS) of patients with gastric or gastroesophageal cancer after surgical resection depending on the preoperative PNI value. The PRISMA algorithm was used in the screening process and finally 16 studies were included in this systematic review. The review protocol was registered in the International Prospective Register of Systematic Reviews (PROSPERO).

resultsSixteen studies involving 14551 patients with gastric or esophagogastric junction adenocarcinoma undergoing open or laparoscopic or robotic gastrectomy with or without adjuvant chemotherapy were included in this systematic review. The patients were divided into high- and low-PNI groups according to cut-off values that were set according to previous reports or by using receiver operating characteristic curve analysis in each individual study. The 5-year OS of patients in the low-PNI groups ranged between 39% and 70.6%, while in the high-PNI groups, it ranged between 54.9% and 95.8%. In most of the included studies, patients with high preoperative PNI showed statistically significant better OS than the low PNI groups. In multivariate analyses, low PNI was repeatedly recognised as an independent prognostic factor for poor survival.

conclusionAccording to the present study, low preoperative PNI seems to be an indicator of poor OS of patients undergoing gastrectomy for gastric or gastroesophageal cancer.

Indexed as

Gastric adenocarcinomaGastroesophageal junction cancerOverall survivalPrognosisPrognostic nutritional index

Identifiers

PMID38425390
PMCPMC10900152

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