SynthesisAlzheimer's & dementia : the journal of the Alzheimer's Association2024
Early detection of diseases causing dementia using digital navigation and gait measures: A systematic review of evidence.
Synthesis in Alzheimer's & dementia : the journal of the Alzheimer's Association, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
16 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Early detection of diseases causing dementia using digital navigation and gait measures: A systematic review of evidence.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2024Pooled it
- Walking as a Window to the Brain: Redefining Gait in Neurology.Medical sciences (Basel, Switzerland) · 2026Review
- Passive digital health technologies for Alzheimer's disease screening and diagnosis: a systematic review.NPJ digital medicine · 2026Article
- Turning versus straight walking under dual-task conditions: a preliminary study for identifying mild cognitive impairment and Alzheimer's disease.BMC neurology · 2026Article
- Clinical translation of fluid, imaging, and digital biomarkers for Alzheimer's disease.Alzheimer's research & therapy · 2026Review
- Beyond single-modality screening: toward an EEG-IoT dual-stream framework for early detection of mild cognitive impairment in community-dwelling older adults.Frontiers in aging neuroscience · 2026Article
- Using Virtual Reality to Assess Spatial Navigation Ability in Individuals With Mild Cognitive Impairment and Older Adults: Cross-Sectional Study.JMIR aging · 2025Article
- Structural brain correlates of neuropsychomotor performance in older adults with early cognitive decline.World journal of psychiatry · 2025Article
- AI-Based Severity Classification of Dementia Using Gait Analysis.Sensors (Basel, Switzerland) · 2025Article
- Link of gray matter volume to cognitive and motor function in elderly patients with mild cognitive impairment.World journal of psychiatry · 2025Article
- Talking during walking: the diagnostic potential of turn dynamics in Alzheimer's disease, mild cognitive impairment and cognitive aging.Frontiers in aging neuroscience · 2025Article
- Perceptual learning and neural correlates of virtual navigation in subjective cognitive decline: A pilot study.iScience · 2024Article
- Identifying older adults at risk for dementia based on smartphone data obtained during a wayfinding task in the real world.PLOS digital health · 2024Article
- Guardians of memory: The urgency of early dementia screening in an aging society.Intractable & rare diseases research · 2024Review
- Subjective spatial orientation discomfort is associated with decreased real-world spatial performance and lower cognitive function.Frontiers in neuroscience · 2024Article
- An experimental framework for conjoint measures of olfaction, navigation, and motion as pre-clinical biomarkers of Alzheimer's disease.Journal of Alzheimer's disease reports · 2024Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
Abstract
Wearable digital technologies capable of measuring everyday behaviors could improve the early detection of dementia-causing diseases. We conducted two systematic reviews following Preferred Reporting Items for Systematic reviews and Meta-Analyses (PRISMA) guidelines to establish the evidence base for measuring navigation and gait, two everyday behaviors affected early in AD and non-AD disorders and not adequately measured in current practice. PubMed and Web of Science databases were searched for studies on asymptomatic and early-stage symptomatic individuals at risk of dementia, with the Newcastle-Ottawa Scale used to assess bias and evaluate methodological quality. Of 316 navigation and 2086 gait records identified, 27 and 83, respectively, were included in the final sample. We highlight several measures that may identify at-risk individuals, whose quantifiability with different devices mitigates the risk of future technological obsolescence. Beyond navigation and gait, this review also provides the framework for evaluating the evidence base for future digital measures of behaviors considered for early disease detection.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.