ReviewStress (Amsterdam, Netherlands)2024
Multi-omics in stress and health research: study designs that will drive the field forward.
Review in Stress (Amsterdam, Netherlands), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
15 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Metabolomics in stress-related disorders: a systematic review and bioinformatics analysis.Naunyn-Schmiedeberg's archives of pharmacology · 2026Pooled it
- Grief-Related Chest Pain: A Review, Conceptual Analysis, and Integrative Model.Psychophysiology · 2026Pooled it
- Advancing women's mental health: Recommendations from a National Academies of Sciences, Engineering, and Medicine workshop.PNAS nexus · 2026Article
- Consensus Statements-Optimizing Performance of the Elite Athlete.Scandinavian journal of medicine & science in sports · 2025Review
- Stress tests and biomarkers of resilience: Proceedings of the second state of resilience science conference.Journal of the American Geriatrics Society · 2025Article
- Dynamic Lipidome Reorganization in Response to Heat Shock Stress.International journal of molecular sciences · 2025Article
- Rethinking Depression-Beyond Neurotransmitters: An Integrated Psychoneuroendocrineimmunology Framework for Depression's Pathophysiology and Tailored Treatment.International journal of molecular sciences · 2025Review
- How community connection, homophobia, and racism shape gene expression in sexual minority men with and without HIV.Health psychology : official journal of the Division of Health Psychology, American Psychological Association · 2025Article
- Dynamic Lipidome Reorganization in Response to Heat Shock Stress.bioRxiv : the preprint server for biology · 2025Article
- Identification of Proactive Health Behavior Clusters in Atrial Fibrillation-Related Ischemic Stroke Patients: A Multi-Center Latent Class Analysis.Vascular health and risk management · 2025Observational
- The effects of childhood adversity on twenty-five disease biomarkers and twenty health conditions in adulthood: Differences by sex and stressor type.Brain, behavior, and immunity · 2025Article
- RNA Editing Signatures Powered by Artificial Intelligence: A New Frontier in Differentiating Schizophrenia, Bipolar, and Schizoaffective Disorders.International journal of molecular sciences · 2024Article
- AMP-Activated Protein Kinase Treatment Ameliorates Chronic Restraint Stress Induced Memory Impairment in Early Adolescent Rat by Restoring Metabolite Profile and Synaptic Proteins.Neurochemical research · 2024Article
- Neurobehavioral dysfunction in a mouse model of Down syndrome: upregulation of cystathionine β-synthase, HGeroScience · 2024Article
- Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
Abstract
Despite decades of stress research, there still exist substantial gaps in our understanding of how social, environmental, and biological factors interact and combine with developmental stressor exposures, cognitive appraisals of stressors, and psychosocial coping processes to shape individuals' stress reactivity, health, and disease risk. Relatively new biological profiling approaches, called multi-omics, are helping address these issues by enabling researchers to quantify thousands of molecules from a single blood or tissue sample, thus providing a panoramic snapshot of the molecular processes occurring in an organism from a systems perspective. In this review, we summarize two types of research designs for which multi-omics approaches are best suited, and describe how these approaches can help advance our understanding of stress processes and the development, prevention, and treatment of stress-related pathologies. We first discuss incorporating multi-omics approaches into theory-rich, intensive longitudinal study designs to characterize, in high-resolution, the transition to stress-related multisystem dysfunction and disease throughout development. Next, we discuss how multi-omics approaches should be incorporated into intervention research to better understand the transition from stress-related dysfunction back to health, which can help inform novel precision medicine approaches to managing stress and fostering biopsychosocial resilience. Throughout, we provide concrete recommendations for types of studies that will help advance stress research, and translate multi-omics data into better health and health care.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.