Evidence map›Paper›PMID 38425049›Full record

ArticleRenal failure2024

Advancing the application of the analytical renal pathology system in allograft IgA nephropathy patients.

Xumeng Liu, Huiwen Fang, Dongmei Liang, Qunjuan Lei, Jiaping Wang, Feng Xu, Shaoshan Liang, Dandan Liang, Fan Yang, Heng Li and 4 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Renal failure, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

Who cites it

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4 · The record

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5 · Who and what money

Authors and funding

14 authors.

Xumeng LiuNational Clinical Research Center for Kidney Diseases, Jinling Hospital, Affiliated Hospital of Medical School, Nanjing University, Nanjing, China.
Huiwen FangNational Clinical Research Center for Kidney Diseases, Jinling Hospital, Affiliated Hospital of Medical School, Nanjing University, Nanjing, China.
Dongmei LiangNational Clinical Research Center for Kidney Diseases, Jinling Hospital, Affiliated Hospital of Medical School, Nanjing University, Nanjing, China.
Qunjuan LeiNational Clinical Research Center for Kidney Diseases, Jinling Hospital, Affiliated Hospital of Medical School, Nanjing University, Nanjing, China.
Jiaping WangPing An Healthcare Technology, Shanghai, China.
Feng XuNational Clinical Research Center for Kidney Diseases, Jinling Hospital, Affiliated Hospital of Medical School, Nanjing University, Nanjing, China.
Shaoshan LiangNational Clinical Research Center for Kidney Diseases, Jinling Hospital, Affiliated Hospital of Medical School, Nanjing University, Nanjing, China.
Dandan LiangNational Clinical Research Center for Kidney Diseases, Jinling Hospital, Affiliated Hospital of Medical School, Nanjing University, Nanjing, China.
Fan YangNational Clinical Research Center for Kidney Diseases, Jinling Hospital, Affiliated Hospital of Medical School, Nanjing University, Nanjing, China.
Heng LiKidney Disease Center, First Affiliated Hospital, College of Medicine, Zhejiang University, Zhejiang, China.
Jianghua ChenKidney Disease Center, First Affiliated Hospital, College of Medicine, Zhejiang University, Zhejiang, China.
Yuan NiPing An Healthcare Technology, Shanghai, China.
Guotong XiePing An Healthcare Technology, Shanghai, China.
Caihong ZengNational Clinical Research Center for Kidney Diseases, Jinling Hospital, Affiliated Hospital of Medical School, Nanjing University, Nanjing, China.ORCID 0000-0002-3816-5164

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThe analytical renal pathology system (ARPS) based on convolutional neural networks has been used successfully in native IgA nephropathy (IgAN) patients. Considering the similarity of pathologic features, we aim to evaluate the performance of the ARPS in allograft IgAN patients and broaden its implementation.

methodsBiopsy-proven allograft IgAN patients from two different centers were enrolled for internal and external validation. We implemented the ARPS to identify glomerular lesions and intrinsic glomerular cells, and then evaluated its performance. Consistency between the ARPS and pathologists was assessed using intraclass correlation coefficients. The association of digital pathological features with clinical and pathological data was measured. Kaplan-Meier survival curve and cox proportional hazards model were applied to investigate prognosis prediction.

resultsA total of 56 biopsy-proven allograft IgAN patients from the internal center and 17 biopsy-proven allograft IgAN patients from the external center were enrolled in this study. The ARPS was successfully applied to identify the glomerular lesions (F1-score, 0.696-0.959) and quantify intrinsic glomerular cells (F1-score, 0.888-0.968) in allograft IgAN patients rapidly and precisely. Furthermore, the mesangial hypercellularity score was positively correlated with all mesangial metrics provided by ARPS [Spearman's correlation coefficient (

conclusionWe propose that the ARPS could be implemented in future clinical practice with outstanding capability.

Indexed as

Glomerulonephritis, IGAAllograftsEndothelial CellsHumansKidney GlomerulusPrognosisRetrospective StudiesTransplantation, Homologousallograft IgANDeep learningglomerular lesionintrinsic glomerular celloutcome

Identifiers

PMID38425049
PMCPMC10911252

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.