ArticleTropical medicine and health2024
Phenotypic characterization of ESBL-producing urinary isolates of E. coli and Klebsiella spp. in a tertiary care children's hospital in Nepal.
Article in Tropical medicine and health, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed, 11 citations in OpenAlex.
- Prevalence, antibiotic susceptibility and associated risk factors for extended spectrum beta-lactamase-producing Enterobacteriaceae among patients suspected with urinary tract infection at Nigist Eleni Mohammed Memorial Hospital, Ethiopia.BMC infectious diseases · 2026Article
- Urinary Tract Infections in Children - Microbiological Challenges and Mechanisms of Bacterial Resistance.Maedica · 2026Review
- Clinical Characteristics and Antimicrobial Resistance ofInfection and drug resistance · 2026Article
- "Multidrug-Resistant Achromobacter isolated from soil: an emerging pathogen".BMC microbiology · 2025Article
- Bacterial etiology and antimicrobial resistance patterns of pediatric UTIs in the West bank, Palestine: a cross-sectional study.BMC pediatrics · 2025Article
- Incidence and antimicrobial susceptibility profiles of multi-drug resistant Klebsiella pneumoniae strains isolated from diseased Clarias gariepinus.Brazilian journal of microbiology : [publication of the Brazilian Society for Microbiology] · 2025Article
- Prevalence, Risk Factors and Antibiotic Resistance of Extended-Spectrum Beta-Lactamase-ProducingChildren (Basel, Switzerland) · 2024Article
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5 authors at 3 institutions in 2 countries.
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No grant is acknowledged in the PubMed record.
Abstract
backgroundThe production of extended-spectrum beta-lactamases (ESBLs) among uropathogens, particularly E. coli and Klebsiella spp., poses a severe public health concern. This study explored the epidemiology of ESBL-producing E. coli and Klebsiella spp. isolated from urine samples obtained at a tertiary care children's hospital in Nepal.
methodsA cross-sectional study was conducted from August 2016 to February 2017. A total of 745 clean catch urine samples were obtained from pediatric patients under the age of 13 and subjected to semiquantitative culture. E. coli and Klebsiella spp. were identified using standard laboratory protocols. Antibiotic susceptibility testing was performed using the Kirby-Bauer disc diffusion method, and ESBL producers were phenotypically identified using the combined disk method.
resultsAmong the bacterial isolates, E. coli predominated, accounting for 139 (81.8%) positive cases. Notably, E. coli showed high susceptibility to nitrofurantoin, with 117 (84.2%) isolates being susceptible. Meanwhile, K. pneumoniae showed high susceptibility to gentamicin, with 21 (91.3%) isolates being susceptible. Of the 163 isolates of E. coli and Klebsiella spp., 62 (38.0%) were identified as multidrug-resistant (MDR), with 42 (25.8%) confirmed as phenotypic ESBL producers. Remarkably, all 41 (100%) ESBL-producing E. coli isolates were susceptible to imipenem.
conclusionsThe prevalence of ESBL producers among E. coli and K. pneumoniae isolates from pediatric patients underscores the importance of antimicrobial stewardship. Nitrofurantoin and gentamicin emerge as effective empirical treatment choices against these pathogens in children. However, the high rates of multidrug resistance and ESBL production highlight the necessity for routine surveillance, and early detection strategies to manage such infections effectively.
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