Evidence map›Paper›PMID 38424597›Full record

ArticlePilot and feasibility studies2024

Flexible bronchoscopy insufflated and high-flow nasal oxygen pilot trial (BUFFALO protocol pilot trial).

Susan Humphreys, Andreas Schibler, Tara Williams, Susan Spall, Trang Pham, Tiffany Atkins, Vikas Goyal, David Sommerfield, Aine Sommerfield, Adam Keys and 2 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Pilot and feasibility studies, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.6field-weighted citation impact, top 35% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 citations in OpenAlex.

  1. Trial
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 5 institutions in 1 country.

Susan HumphreysDepartment of Anaesthesia, Queensland Children's Hospital, South Brisbane, Queensland, Australia. susan.humphreys@uq.edu.au.ORCID http://orcid.org/0000-0003-0286-2088
Andreas SchiblerWesley Research Institute, Wesley Hospital, Auchenflower, Australia.
Tara WilliamsChildren's Health Research Centre, The University of Queensland, Brisbane, Australia.
Susan SpallDepartment of Anaesthesia, Queensland Children's Hospital, South Brisbane, Queensland, Australia.
Trang PhamChildren's Health Research Centre, The University of Queensland, Brisbane, Australia.
Tiffany AtkinsInstitute for Evidence-Based Healthcare, Bond University, Robina, Queensland, Australia.
Vikas GoyalAustralian Centre for Health Services Innovation, Queensland University of Technology, Brisbane, Queensland, Australia.
David SommerfieldDepartment of Anaesthesia and Pain Medicine, Perth Children's Hospital, Nedlands, Western Australia, Australia.
Aine SommerfieldDepartment of Anaesthesia and Pain Medicine, Perth Children's Hospital, Nedlands, Western Australia, Australia.
Adam KeysDepartment of Anaesthesia, Queensland Children's Hospital, South Brisbane, Queensland, Australia.
Neil HauserDepartment of Anaesthesia and Pain Medicine, Perth Children's Hospital, Nedlands, Western Australia, Australia.
Britta S von Ungern-SternbergDepartment of Anaesthesia and Pain Medicine, Perth Children's Hospital, Nedlands, Western Australia, Australia.
Children's Medical Research Institute · AUThe Kids Research Institute Australia · AUBond University · AUQueensland University of Technology · AUWesley Hospital · AU

Funding

Australian and New Zealand College of Anaesthetists 22/025
6 · The paper itself

Abstract

backgroundHypoxaemia occurs in approximately 30% of children during anaesthesia for flexible bronchoscopy. High-flow nasal oxygen (HFNO) can prolong safe apnoea time and be used in children with abnormal airways. During flexible bronchoscopy, there is limited evidence if HFNO confers advantages over current standard practice in avoiding hypoxaemia. The aim is to investigate feasibility of HFNO use during anaesthesia for flexible bronchoscopy to reduce frequency of rescue oxygenation and hypoxaemia.

methodsBUFFALO is a bi-centre, unmasked, randomised controlled, parallel group, protocol for a pilot trial comparing HFNO techniques to standard practice during anaesthesia. Children (n = 81) aged > 37 weeks to 16 years presenting for elective bronchoscopy who fulfil inclusion but not exclusion criteria will be randomised prior to the procedure to HFNO or standard care oxygenation post induction of anaesthesia. Maintenance of anaesthesia with HFNO requires total venous anaesthesia (TIVA) and with standard, either inhalational or TIVA at discretion of anaesthetist in charge of the patient. Outcomes will include the feasibility of recruitment and adherence to trial procedures, acceptability of the intervention of the protocol and completion rates of data collection methods. DISCUSSION: Findings of this trial will determine feasibility to plan for a larger multicentre randomised clinical trial and support the feasibility of the proposed study procedures.

trial registrationBUFFALO trial was registered with Australia and New Zealand Clinical Trials Registry (TRN12621001635853) on 29 November 2021 and commenced recruitment in May 2022. https://www.anzctr.org.au/ . The primary manuscript will be submitted for publication in a peer-reviewed journal.

Indexed as

AnaesthesiaChildrenHigh-flowHypoxaemiaPaediatric

Identifiers

PMID38424597
PMCPMC10902996
OpenAlexW4392289298

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.