Evidence map›Paper›PMID 38424578›Full record

ArticleJournal of nanobiotechnology2024

Development of finely tuned liposome nanoplatform for macrophage depletion.

Tae Hyeon Choi, Ran Ji Yoo, Ji Yong Park, Ji Yoon Kim, Young Chan Ann, Jeongbin Park, Jin Sil Kim, Kyuwan Kim, Yu Jin Shin, Yong Jin Lee and 6 more

Open access · goldAbstract read
In one paragraph

Article in Journal of nanobiotechnology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed
4.1field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 17 citations in OpenAlex.

  1. Article
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  4. Spleen-associated macrophage alterations and embryo viability in a murine model of recurrent spontaneous abortion.Inflammation research : official journal of the European Histamine Research Society ... [et al.] · 2026
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  16. Macrophage-targetedScience advances · 2025
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors at 2 institutions in 1 country.

Tae Hyeon Choi *Department of Nuclear Medicine, Seoul National University College of Medicine, Seoul, South Korea.
Ran Ji Yoo *Department of Nuclear Medicine, Seoul National University College of Medicine, Seoul, South Korea.
Ji Yong ParkDepartment of Nuclear Medicine, Seoul National University College of Medicine, Seoul, South Korea.
Ji Yoon KimDepartment of Nuclear Medicine, Seoul National University College of Medicine, Seoul, South Korea.
Young Chan AnnDepartment of Nuclear Medicine, Seoul National University College of Medicine, Seoul, South Korea.
Jeongbin ParkDepartment of Molecular Medicine and Biopharmaceutical Sciences, Graduate School of Convergence Science and Technology, Seoul National University, Seoul, 08826, South Korea.
Jin Sil KimDepartment of Nuclear Medicine, Seoul National University College of Medicine, Seoul, South Korea.
Kyuwan KimDepartment of Nuclear Medicine, Seoul National University College of Medicine, Seoul, South Korea.
Yu Jin ShinDepartment of Nuclear Medicine, Seoul National University College of Medicine, Seoul, South Korea.
Yong Jin LeeDivision of Applied RI, Korea Institute of Radiological and Medical Sciences (KIRAMS), Seoul, South Korea.
Kyo Chul LeeDivision of Applied RI, Korea Institute of Radiological and Medical Sciences (KIRAMS), Seoul, South Korea.
Jisu ParkCancer Research Institute, Seoul National University College of Medicine, Seoul, South Korea.
Hyewon ChungCancer Research Institute, Seoul National University College of Medicine, Seoul, South Korea.
Seung Hyeok SeokCancer Research Institute, Seoul National University College of Medicine, Seoul, South Korea.
Hyung-Jun ImDepartment of Molecular Medicine and Biopharmaceutical Sciences, Graduate School of Convergence Science and Technology, Seoul National University, Seoul, 08826, South Korea. iiihjjj@snu.ac.kr.
Yun-Sang LeeDepartment of Nuclear Medicine, Seoul National University College of Medicine, Seoul, South Korea. wonza43@snu.ac.kr.
Seoul National University · KRKorea Institute of Radiological and Medical Sciences · KR

Funding

Ministry of Health and Welfare HN22C0644National Research Foundation of Korea 2021R1A2C3009427National Research Foundation of Korea 2021R1C1C2004706
6 · The paper itself

Abstract

backgroundImmunotherapy with clodronate-encapsulated liposomes, which induce macrophage depletion, has been studied extensively. However, previously reported liposomal formulation-based drugs (Clodrosome

resultsWe developed four types of click chemistry-based liposome nanoplatforms that were uniformly sized and encapsulated with clodronate, for effective macrophage depletion, followed by conjugation with Man-N

conclusionThe newly-developed liposome nanoplatform, with finely tuned size control, high in vivo stability, and excellent ex vivo M2 macrophage targeting and depletion effects, is a promising macrophage-depleting agent.

Indexed as

Clodronic AcidLiposomesHumansMacrophagesMaleTissue DistributionClodronic AcidLiposomesClick chemistryClodronateLiposomeMacrophageMolecular imaging

Identifiers

PMID38424578
PMCPMC10903058
OpenAlexW4392298518

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.