ArticleBMC women's health2024
Comparison of microbial abundance and diversity in uterine and peritoneal fluid in infertile patients with or without endometriosis.
Article in BMC women's health, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed, 10 citations in OpenAlex.
- The Effects and Mechanisms Underlying Red Meat Diet on Endometriosis Through Modulating Gut Microbiota.Food science & nutrition · 2026Article
- Vaginal Dysbiosis in Infertility: A Comparative Analysis Between Women with Primary and Secondary Infertility.Microorganisms · 2025Article
- Comparison of the lower genital tract microbiome composition in patients with benign gynecological disease.Frontiers in global women's health · 2025Article
- Microbiome dysbiosis and endometriosis: a systematic scoping review of current literature and knowledge gaps.Human reproduction open · 2025Review
- Acupuncture mediates the "gut-testis axis" to improve asthenozoospermia.Frontiers in endocrinology · 2025Article
- Update on the pathogenesis of endometriosis-related infertility based on contemporary evidence.Frontiers in endocrinology · 2025Review
- Correction: Comparison of microbial abundance and diversity in uterine and peritoneal fluid in infertile patients with or without endometriosis.BMC women's health · 2024Article
Corrections and comments
- Erratum issued
Authors and funding
9 authors at 2 institutions in 1 country.
Funding
Abstract
introductionEndometriosis (EM) is a multifactorial disease that affects 10 - 15% of women of reproductive age. Additionally, 30-50% of women with EM suffer from infertility. The mechanism of infertility caused by EM has not yet been consistently explained. In recent years, studies have shown a link between infertility associated with EM and changes in the reproductive tract microbiota.
methodsIn this study, we involved 26 EM patients (8 cases of stage I-II and 18 cases of stage III-IV) and 31 control subjects who were tubal obstruction-related infertility (TORI). The samples from peritoneal fluid (PF) and uterine fluid (UF) were collected and sequenced by 16 S rRNA amplicon.
resultsIn the comparison of microbial diversity, we found no significant differences in the microbial diversity of PF and UF between patients with stage I-II EM and those with TORI. However, there was a significant difference in microbial diversity among patients with stage III-IV EM compared to the previous two groups. Lactobacillus decreased in PF of EM compared to the control group, while it increased in UF. In PF, the abundance of Pseudomonas, Enterococcus, Dubosiella and Klebsiella was significantly higher in patients with stage III-IV compared to TORI patients. And in UF, the main differences existed between stage I-II EM compared to the other two groups. The abundance of pontibacter, aquabacterium, Rikenellaceae and so on at the genus level was significantly enriched in the EM patients with stage I-II. In the analysis based on KEGG database, EM may affect the receptivity related pathways of the endometrium by influencing changes in the uterine microbiota.
conclusionOur results indicated that as EM progresses, the microorganisms in UF and PF keep changing. These changes in the microbiota, as well as the resulting alternations in gene functional classification, may play an important role in the infertility associated with EM.
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