Evidence map›Paper›PMID 38424483›Full record

SynthesisBMC cardiovascular disorders2024

Catheter ablation versus medical therapy in atrial fibrillation: an umbrella review of meta-analyses of randomized clinical trials.

Anoop Titus, Sakil Syeed, Abiram Baburaj, Karan Bhanushali, Pramod Gaikwad, Mannil Sooraj, Anu Mariam Saji, Wasey Ali Yadullahi Mir, Pramukh Arun Kumar, Mahati Dasari and 16 more

Abstract readSystematic Review
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in BMC cardiovascular disorders, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

26 authors.

Anoop Titus *DeBakey Heart and Vascular Center, Houston Methodist, Houston, TX, USA.
Sakil Syeed *University of Utah, Salt Lake City, UT, USA.
Abiram BaburajQueen's University Belfast, Belfast, UK. ababuraj01@qub.ac.uk.
Karan BhanushaliRoger Williams Medical Center, Providence, RI, USA.
Pramod GaikwadMassachusetts General Hospital, Boston, MA, USA.
Mannil SoorajDr. Chandramma Dayananda Sagar Institute of Medical Education and Research, Kanakapura, Karnataka, India.
Anu Mariam SajiSaint Vincent Hospital, Worcester, MA, USA.
Wasey Ali Yadullahi MirSaint Elizabeth Medical Center, Boston, MA, USA.
Pramukh Arun KumarSaint Vincent Hospital, Worcester, MA, USA.
Mahati DasariSaint Vincent Hospital, Worcester, MA, USA.
Mubashir Ayaz AhmedAscension Saint Joseph Hospital, Chicago, IL, USA.
Mohammed Omer KhanRush University Medical Center, Chicago, IL, USA.
Aishwarya TitusPushpagiri Institute of Medical Sciences and Research Centre, Thiruvalla, Kerala, India.
Janamjey GaurSaint Vincent Hospital, Worcester, MA, USA.
Dilanthy AnnappahCanton Medical Education Foundation, Canton, OH, USA.
Arjun RajUniversity Hospital of Leicester, Leicester, UK.
Nabeela NoreenRajshahi Medical College, Rajshahi, Bangladesh.
Adrian HasdiandaBrigham and Women's Hospital, Harvard University, Cambridge, MA, USA.
Yasar SattarWest Virginia University, Morgantown, WV, USA.
Bharat NarasimhanDeBakey Heart and Vascular Center, Houston Methodist, Houston, TX, USA.
Nishaki MehtaBeaumont Hospital Royal Oak, Oakland University William Beaumont School of Medicine, Royal Oak, MI, USA.
Christopher V DesimoneMayo Clinic, Rochester, Minnesota, USA.
Abhishek DeshmukhMayo Clinic, Rochester, Minnesota, USA.
Sarju GanatraDepartment of Cardiology, Lahey Hospital and Medical Center, Beth Israel Lahey Health, 41 Mall Road, Burlington, MA, 10805, USA.
Khurram NasirDeBakey Heart and Vascular Center, Houston Methodist, Houston, TX, USA.
Sourbha DaniDepartment of Cardiology, Lahey Hospital and Medical Center, Beth Israel Lahey Health, 41 Mall Road, Burlington, MA, 10805, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

This umbrella review synthesizes data from 17 meta-analyses investigating the comparative outcomes of catheter ablation (CA) and medical treatment (MT) for atrial fibrillation (AF). Outcomes assessed were mortality, risk of hospitalization, AF recurrence, cardiovascular events, pulmonary vein stenosis, major bleeding, and changes in left ventricular ejection fraction (LVEF) and MLHFQ score. The findings indicate that CA significantly reduces overall mortality and cardiovascular hospitalization with high strength of evidence. The risk of AF recurrence was notably lower with CA, with moderate strength of evidence. Two associations reported an increased risk of pulmonary vein stenosis and major bleeding with CA, supported by high strength of evidence. Improved LVEF and a positive change in MLHFQ were also associated with CA. Among patients with AF and heart failure, CA appears superior to MT for reducing mortality, improving LVEF, and reducing cardiovascular rehospitalizations. In nonspecific populations, CA reduced mortality and improved LVEF but had higher complication rates. Our findings suggest that CA might offer significant benefits in managing AF, particularly in patients with heart failure. However, the risk of complications, including pulmonary vein stenosis and major bleeding, is notable. Further research in understudied populations may help refine these conclusions.

Indexed as

Atrial FibrillationCatheter AblationHeart FailureStenosis, Pulmonary VeinHemorrhageHumansMeta-Analysis as TopicRandomized Controlled Trials as TopicStroke VolumeTreatment OutcomeVentricular Function, LeftAtrial fibrillationCardiovascular hospitalizationCatheter ablationHeart failureLeft ventricular ejection fractionMajor bleedingMedical treatmentMeta-analysisMortalityPulmonary vein stenosis

Identifiers

PMID38424483
PMCPMC10902941

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.