Observational studyScientific reports2024
Characteristic functional connectome related to Post-COVID-19 syndrome.
Observational study in Scientific reports, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
20 citing papers in PubMed, 1 synthesis or guideline pooled it, 23 citations in OpenAlex.
- [Cognition and Long COVID: A PRISMA Systematic Review of Longitudinal Studies].Revista de neurologia · 2025Pooled it
- Functional brain abnormalities in post COVID-19 condition and their relationship with cognition.Scientific reports · 2025Trial
- Resting-state functional connectivity and cognitive impairment after COVID-19 infection: Evidence from a large-scale fMRI study.European psychiatry : the journal of the Association of European Psychiatrists · 2026Article
- Thalamic homeostatic transcriptomic signatures are altered in a mouse model of cholestatic liver injury and are mitigated by systemic TNF neutralization.Molecular brain · 2026Article
- Intra and inter-network functional connectivity among long-Covid patients with ongoing disease duration.Scientific reports · 2026Article
- Brain connectivity and its relation to cognitive function in patients with post-COVID 19 condition after mild infection.Scientific reports · 2026Article
- Longitudinal modeling of Post-COVID-19 condition over three years: A machine learning approach using clinical, neuropsychological, and fluid markers.Scientific reports · 2026Article
- Acupuncture for cognitive functions in post-COVID-19 condition: study protocol of a three-armed, randomized controlled trial with multimodal MRI.Frontiers in medicine · 2026Article
- Association of structural brain changes with cognitive deficits and fatigue in patients with post-COVID-19 condition.Brain communications · 2026Article
- Assessment of dynamic cerebral blood flow changes during cognitive tasks in patients with post-COVID-19 syndrome.Brain communications · 2026Article
- Reconceptualizing rehabilitation research via an enactive framework and a radically interdisciplinary cross-analysis: a study protocol on fatigue in post COVID-19 condition (PCC).Journal of rehabilitation medicine · 2025Article
- Two-year impact of COVID-19: Longitudinal MRI brain changes and neuropsychiatric trajectories.Psychiatry and clinical neurosciences · 2025Article
- Factors associated with reduction in quality of life after SARS-CoV-2 infection.Scientific reports · 2025Article
- Evaluating contributions of neuropsychological, psychiatric, and inflammatory processes to the expression of cognitive symptoms in post-acute COVID-19 syndrome.Frontiers in psychiatry · 2025Article
- Altered putamen connectivity in patients with neurological post-COVID condition.Brain communications · 2025Article
- Functional Connectivity Alterations Associated with COVID-19-Related Sleep Problems: A Longitudinal Resting-State fMRI Study.Nature and science of sleep · 2025Article
- Evidence of clinical and brain recovery in post-COVID-19 condition: a three-year follow-up study.Brain communications · 2025Article
- Altered functional brain connectivity, efficiency, and information flow associated with brain fog after mild to moderate COVID-19 infection.Scientific reports · 2024Article
- Cognitive profile, neuroimaging and fluid biomarkers in post-acute COVID-19 syndrome.Scientific reports · 2024Article
- Multimodal neuroimaging in Long-COVID and its correlates with cognition 1.8 years after SARS-CoV-2 infection: a cross-sectional study of theFrontiers in neurology · 2024Article
Corrections and comments
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Authors and funding
11 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Post-COVID-19 syndrome is a serious complication following SARS-CoV-2 infection, characterized primarily by fatigue and cognitive complaints. Although first metabolic and structural imaging alterations in Post-COVID-19 syndrome have been identified, their functional consequences remain unknown. Thus, we explored the impact of Post-COVID-19 syndrome on the functional connectome of the brain providing a deeper understanding of pathophysiological mechanisms. In a cross-sectional observational study, resting-state functional magnetic resonance imaging data of 66 patients with Post-COVID-19 syndrome after mild infection (mean age 42.3 years, 57 female) and 57 healthy controls (mean age 42.1 years, 38 female) with a mean time of seven months after acute COVID-19 were analysed using a graph theoretical approach. Network features were quantified using measures including mean distance, nodal degree, betweenness and Katz centrality, and compared between both groups. Graph measures were correlated with clinical measures quantifying fatigue, cognitive function, affective symptoms and sleep disturbances. Alterations were mainly found in the brainstem, olfactory cortex, cingulate cortex, thalamus and cerebellum on average seven months after SARS-CoV-2 infection. Additionally, strong correlations between fatigue severity, cognitive functioning and daytime sleepiness from clinical scales and graph measures were observed. Our study confirms functional relevance of brain imaging changes in Post-COVID-19 syndrome as mediating factors for persistent symptoms and improves our pathophysiological understanding.
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