ReviewNature cell biology2024
A guideline on the molecular ecosystem regulating ferroptosis.
Open access · greenAbstract readReview
In one paragraph
Review in Nature cell biology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 149 papers, 2 of them syntheses that pooled it.
0numbers the graph read from it
0cells of the map it votes in
149citing papers in PubMed, 2 pooled it
93.4field-weighted citation impact, top 1% of its field
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
149 citing papers in PubMed, 2 syntheses or guidelines pooled it, 223 citations in OpenAlex.
- Current perspectives and trend of ferroptosis in head and neck cancer: a bibliometric analysis.Frontiers in oral health · 2025Pooled it
- A Risk Model Based on Ferroptosis-Related Genes OSMR, G0S2, IGFBP6, IGHG2, and FMOD Predicts Prognosis in Glioblastoma Multiforme.CNS neuroscience & therapeutics · 2025Pooled it
- Research progress of ferroptosis in gynecological diseases.Annals of medicine · 2026Review
- Diet-Induced Phospholipid Remodeling Dictates Ferroptosis Sensitivity and Tumorigenesis in the Pancreas.Cancer discovery · 2026Article
- Ferroptosis at the Metabolic-Immune Interface in Metastatic Castration-Resistant Prostate Cancer: Mechanistic Evidence, Translational Gaps, and Combination Strategies.Annals of surgical oncology · 2026Review
- Itaconate metabolism in regulated cell death.Molecular and cellular biochemistry · 2026Review
- The role of ferroptosis in juvenile idiopathic arthritis: Causal inference and mediation by immune phenotypes.Medicine · 2026Article
- Ferrostatin-1 Attenuates CLP-Induced Colonic Injury: Associations with Ferroptosis-Related Alterations, Oxidative Stress, Inflammation, and Treatment Timing.Current issues in molecular biology · 2026Article
- Ferroptotic propagation: from single-cell execution to tissue-scale death programs.Cell research · 2026Review
- Bap1-mediated deubiquitination determines immune tolerance and anti-tumor immunity via modulating eTreg cell differentiation and ferroptosis.Cell death and differentiation · 2026Article
- Reconstituted phospholipid membrane-coated FeBioactive materials · 2026Article
- Context-Dependent Modulation of Ferroptosis by Metformin: Mechanisms, Therapeutic Implications and Open Questions.Pharmaceuticals (Basel, Switzerland) · 2026Review
- Linoleic acid accelerates osteoarthritis progression in male rats by targeting iron-sulfur clusters to drive ferroptosis in chondrocytes.Nature communications · 2026Article
- Unlocking the ferroptotic window: Lipidomic rewiring and metabolic addiction in EMT-driven breast cancer resistance.Cell death discovery · 2026Review
- DHODH-Mediated Suppression of Ferroptosis Supports Radioresistance and Represents a Therapeutic Vulnerability in Lung Cancer.Cancer research · 2026Article
- Emerging roles of ferroptosis in modulating the immune landscape of glial tumours.Nature cell biology · 2026Review
- Article
- Ferroptosis in colorectal cancer: Molecular mechanisms and regulatory crosstalk with therapeutic prospects (Review).Oncology reports · 2026Review
- FABP5 drives ferroptosis in psoriasis.Cell death and differentiation · 2026Article
- Deubiquitinating enzymes-mediated post-translational modifications of ferroptosis regulates cancer drug resistance.Discover oncology · 2026Review
89 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
48 authors at 20 institutions in 12 countries.
Enyong DaiDepartment of Oncology and Hematology, China-Japan Union Hospital of Jilin University, Changchun, China. daiey@jlu.edu.cn.ORCID http://orcid.org/0000-0002-5263-3454
Xin ChenGuangzhou Municipal and Guangdong Provincial Key Laboratory of Protein Modification and Degradation, School of Basic Medical Sciences, Guangzhou Medical University, Guangzhou, China.ORCID http://orcid.org/0000-0003-3668-4830
Andreas LinkermannDivision of Nephrology, Department of Internal Medicine III, University Hospital Carl Gustav Carus at the Technische Universität Dresden, Dresden, Germany.
Xuejun JiangCell Biology Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA.ORCID http://orcid.org/0000-0002-8670-3828
Rui KangDepartment of Surgery, University of Texas Southwestern Medical Center, Dallas, TX, USA.ORCID http://orcid.org/0000-0003-2725-1574
Valerian E KaganDepartment of Environmental Health, University of Pittsburgh, Pittsburgh, PA, USA.ORCID http://orcid.org/0000-0002-7245-1885
Hülya BayirDepartment of Pediatrics, Columbia University, New York, NY, USA.
Wan Seok YangDepartment of Biological Sciences, St. John's University, New York, NY, USA.
Ana J Garcia-SaezInstitute for Genetics, CECAD, University of Cologne, Cologne, Germany.ORCID http://orcid.org/0000-0002-3894-5945
Maria S IoannouDepartment of Physiology, University of Alberta, Edmonton, Alberta, Canada.ORCID http://orcid.org/0000-0001-6252-8626
Tobias JanowitzCold Spring Harbor Laboratory, New York, USA.ORCID http://orcid.org/0000-0002-7820-3727
Qitao RanDepartment of Cell Systems and Anatomy, South Texas Veterans Health Care System, San Antonio, TX, USA.
Wei GuInstitute for Cancer Genetics, and Herbert Irving Comprehensive Cancer Center, Vagelos College of Physicians and Surgeons, Columbia University, New York, NY, USA.ORCID http://orcid.org/0000-0002-1480-2368
Boyi GanDepartment of Experimental Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.ORCID http://orcid.org/0000-0001-8884-6040
Dmitri V KryskoCell Death Investigation and Therapy (CDIT) Laboratory, Department of Human Structure and Repair, Ghent University, Ghent, Belgium.ORCID http://orcid.org/0000-0002-9692-2047
Xiaofeng ZhuState Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, and Guangdong Key Laboratory of Nasopharyngeal Carcinoma Diagnosis and Therapy, Sun Yat-sen University Cancer Center, Guangzhou, China.ORCID http://orcid.org/0000-0002-1250-0796
Jiayi WangDepartment of Clinical Laboratory, Shanghai Institute of Thoracic Oncology, Shanghai Chest Hospital and College of Medical Technology, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Stefan KrautwaldDepartment of Nephrology and Hypertension, University Hospital Schleswig-Holstein, Kiel, Germany.ORCID http://orcid.org/0000-0001-7768-2132
Shinya ToyokuniDepartment of Pathology and Biological Response, Nagoya University Graduate School of Medicine, Nagoya, Japan.ORCID http://orcid.org/0000-0002-5757-1109
Yangchun XieDepartment of Oncology, The Second Xiangya Hospital of Central South University, Changsha, China.
Florian R GretenInstitute for Tumor Biology and Experimental Therapy, Georg-Speyer-Haus, Frankfurt am Main, Germany.ORCID http://orcid.org/0000-0002-3928-6080
Qing YiHouston Methodist Neal Cancer Center/Houston Methodist Research Institute, Houston Methodist Hospital, Houston, Texas, USA.ORCID http://orcid.org/0000-0003-1529-3398
Joel SchickGenetics and Cellular Engineering Group, Institute of Molecular Toxicology and Pharmacology, Helmholtz Zentrum Munich, Neuherberg, Germany.ORCID http://orcid.org/0000-0002-8623-4910
Jiao LiuDAMP Laboratory, The Third Affiliated Hospital of Guangzhou Medical University, Guangzhou, China.
Dmitry I GabrilovichAstraZeneca, Early Oncology R&D, Gaithersburg, MD, USA.ORCID http://orcid.org/0000-0001-9913-6407
Jinbao LiuGuangzhou Municipal and Guangdong Provincial Key Laboratory of Protein Modification and Degradation, School of Basic Medical Sciences, Guangzhou Medical University, Guangzhou, China.ORCID http://orcid.org/0000-0003-2220-2407
Herbert J ZehDepartment of Surgery, University of Texas Southwestern Medical Center, Dallas, TX, USA.
Donna D ZhangDepartment of Pharmacology and Toxicology, College of Pharmacy, University of Arizona, Tucson, AZ, USA.ORCID http://orcid.org/0000-0002-8972-697X
Minghua YangDepartment of Pediatrics, The Third Xiangya Hospital, Central South University, Changsha, China.
Juan IovannaCentre de Recherche en Cancérologie de Marseille (CRCM), INSERM U1068, CNRS UMR 7258, Aix-Marseille Université and Institut Paoli-Calmettes, Marseille, France.
Manfred KopfInstitute of Molecular Health Sciences, Department of Biology, ETH Zurich, Zurich, Switzerland.
Timon E AdolphDepartment of Internal Medicine I, Gastroenterology, Hepatology, Endocrinology, and Metabolism, Medical University of Innsbruck, Innsbruck, Austria.ORCID http://orcid.org/0000-0002-4736-830X
Jen-Tsan ChiDepartment of Molecular Genetics and Microbiology Center for Applied Genomic Technologies, Duke University, Durham, NC, USA.
Changfeng LiDepartment of Endoscopy Center, China-Japan Union Hospital of Jilin University, Changchun, China.
Hidenori IchijoLaboratory of Cell Signaling, Graduate School of Pharmaceutical Sciences, The University of Tokyo, Tokyo, Japan.ORCID http://orcid.org/0000-0002-5005-6438
Michael KarinLaboratory of Gene Regulation and Signal Transduction, Departments of Pharmacology and Pathology, School of Medicine, University of California San Diego, La Jolla, CA, USA.
Vijay G SankaranDivision of Hematology/Oncology, Boston Children's Hospital and Department of Pediatric Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA, USA.ORCID http://orcid.org/0000-0003-0044-443X
Weiping ZouDepartments of Surgery and Pathology, University of Michigan Medical School, Ann Arbor, MI, USA.ORCID http://orcid.org/0000-0001-7952-3549
Lorenzo GalluzziDepartment of Radiation Oncology, Weill Cornell Medical College, New York, NY, USA.ORCID http://orcid.org/0000-0003-2257-8500
Ashley I BushMelbourne Dementia Research Centre, The Florey Institute of Neuroscience and Mental Health, The University of Melbourne, Parkville, Victoria, Australia.ORCID http://orcid.org/0000-0001-8259-9069
Binghui LiDepartment of Biochemistry and Molecular Biology, School of Basic Medical Sciences, Capital Medical University, Beijing, China.ORCID http://orcid.org/0000-0002-6110-8010
Gerry MelinoDepartment of Experimental Medicine, Tor Vergata University of Rome, Rome, Italy.ORCID http://orcid.org/0000-0001-9428-5972
Eric H BaehreckeDepartment of Molecular, Cell and Cancer Biology, University of Massachusetts Chan Medical School, Worcester, MA, USA.ORCID http://orcid.org/0000-0003-1683-5064
Michael T LotzeDepartments of Surgery, Immunology and Bioengineering, University of Pittsburgh, Pittsburgh, PA, USA.ORCID http://orcid.org/0000-0003-3988-5419
Daniel J KlionskyLife Sciences Institute and Department of Molecular, Cellular and Developmental Biology, University of Michigan, Ann Arbor, MI, USA.ORCID http://orcid.org/0000-0002-7828-8118
Brent R StockwellDepartment of Biological Sciences and Department of Chemistry, Columbia University, New York, NY, USA. bs2198@columbia.edu.ORCID http://orcid.org/0000-0002-3532-3868
Guido KroemerEquipe labellisée par la Ligue contre le cancer, Centre de Recherche des Cordeliers, Université de Paris, Sorbonne Université, INSERM U1138, Institut Universitaire de France, Paris, France. kroemer@orange.fr.ORCID http://orcid.org/0000-0002-9334-4405
Daolin TangDepartment of Surgery, University of Texas Southwestern Medical Center, Dallas, TX, USA. daolin.tang@utsouthwestern.edu.ORCID http://orcid.org/0000-0002-1903-6180
Central South University · CNColumbia University · USThe University of Texas Southwestern Medical Center · USThird Affiliated Hospital of Guangzhou Medical University · CNUniversity of Michigan · USUniversity of Pittsburgh · USAlbert Einstein College of Medicine · USAstraZeneca (United States) · USBroad Institute · USCancer Genetics (United States) · USCapital Medical University · CNCentre National de la Recherche Scientifique · FRCold Spring Harbor Laboratory · USCornell University · USDuke University · USETH Zurich · CHGhent University · BEGoethe University Frankfurt · DEGuangzhou Medical University · CNHelmholtz Zentrum München · DE
Funding
X-RAY CRYSTALLOGRAPHYP30CA008748 · NCI · SLOAN-KETTERING INSTITUTE FOR CANCER RES · PI SELWYN M VICKERS · 1985 to 2026
$347.4MSingle-Cell Biology Shared ResourceP30CA045508 · NCI · COLD SPRING HARBOR LABORATORY · PI David A Tuveson · 1987 to 2026
$118.9MALTERNATIVE VACUOLAR TARGETING MECHANISMS IN YEASTR01GM053396 · NIGMS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI KLIONSKY, DANIEL J. · 1995 to 2018
$12.1MThe mechanism and regulation of autophagyR35GM131919 · NIGMS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI DANIEL J. KLIONSKY · 2019 to 2026
$6.4MRegulation of autophagy during animal developmentR35GM131689 · NIGMS · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI Eric H Baehrecke · 2019 to 2026
$4.9MFerroptosis, Cellular Metabolism, and CancerR01CA204232 · NCI · SLOAN-KETTERING INST CAN RESEARCH · PI JIANG, XUEJUN · 2017 to 2025
$4.1MMechanisms and Function of Autophagy in CancerR01CA166413 · NCI · SLOAN-KETTERING INST CAN RESEARCH · PI JIANG, XUEJUN · 2013 to 2023
$3.9MTargeting HMGB1-mediated Autophagy in Cancer TherapyR01CA160417 · NCI · UT SOUTHWESTERN MEDICAL CENTER · PI TANG, DAOLIN · 2012 to 2023
$3.0MFerroptosis and Cancer Cell SignalingR01CA258622 · NCI · SLOAN-KETTERING INST CAN RESEARCH · PI Xuejun Jiang · 2022 to 2026
$2.2MTargeting ACOD1 to attenuate innate immune responses to lethal infectionsR01GM127791 · NIGMS · UT SOUTHWESTERN MEDICAL CENTER · PI Daolin Tang · 2018 to 2026
$2.2MMechanisms of Ferroptotic Cancer Cell DeathR01CA229275 · NCI · UT SOUTHWESTERN MEDICAL CENTER · PI TANG, DAOLIN · 2019 to 2024
$1.8MVPS13D, organelle contact, and cellular stress in models of diseaseR01AG082740 · NIA · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI Eric H Baehrecke · 2023 to 2026
$1.7MNCI NIH HHS P30 CA008748NCI NIH HHS P30 CA045508NCI NIH HHS R01 CA160417NCI NIH HHS R01 CA166413NCI NIH HHS R01 CA204232NCI NIH HHS R01 CA229275NCI NIH HHS R01 CA258622NIA NIH HHS R01 AG082740NIGMS NIH HHS R01 GM053396NIGMS NIH HHS R01 GM127791NIGMS NIH HHS R35 GM131689NIGMS NIH HHS R35 GM131919U.S. Department of Health & Human Services | National Institutes of Health (NIH) 733 310030_170320
Abstract
Ferroptosis, an intricately regulated form of cell death characterized by uncontrolled lipid peroxidation, has garnered substantial interest since this term was first coined in 2012. Recent years have witnessed remarkable progress in elucidating the detailed molecular mechanisms that govern ferroptosis induction and defence, with particular emphasis on the roles of heterogeneity and plasticity. In this Review, we discuss the molecular ecosystem of ferroptosis, with implications that may inform and enable safe and effective therapeutic strategies across a broad spectrum of diseases.
Indexed as
FerroptosisLipid PeroxidationAnimalsGuidelines as TopicHumansIronReactive Oxygen SpeciesSignal TransductionIronReactive Oxygen Species
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