ArticleEMBO reports2024
mTert induction in p21-positive cells counteracts capillary rarefaction and pulmonary emphysema.
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Article in EMBO reports, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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0cells of the map it votes in
9citing papers in PubMed
4.2field-weighted citation impact, top 5% of its field
What it found
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Who cites it
9 citing papers in PubMed, 13 citations in OpenAlex.
- Angiogenesis in Lung Regeneration and Aging.Arteriosclerosis, thrombosis, and vascular biology · 2026Review
- TERT drives liver tumorigenesis beyond telomere elongation.Life science alliance · 2026Article
- Pathogenesis and Phenotypes of Pulmonary Vascular Disease in COPD: A Consensus Statement From the Pulmonary Vascular Research Institute's Innovative Drug Development Initiative - PH Group 3 Workstream.Pulmonary circulation · 2026Article
- Lung mTOR activation leads to lung fibrosis or emphysema via senescence of specific lung cells.Scientific reports · 2026Article
- Microvascular Health as a Key Determinant of Organismal Aging.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Review
- Piezo1 in PASMCs: Critical for Hypoxia-Induced Pulmonary Hypertension Development.Circulation research · 2025Article
- Premature ageing of lung alveoli and bone marrow cells from Terc deficient mice with different telomere lengths.Scientific reports · 2025Article
- Noncoding RNA Terc-53 and hyaluronan receptor Hmmr regulate aging in mice.Protein & cell · 2025Article
- Mechanisms of cellular senescence-induced vascular aging: evidence of senotherapeutic strategies.The journal of cardiovascular aging · 2025Article
Corrections and comments
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Authors and funding
22 authors at 4 institutions in 3 countries.
Larissa Lipskaia *Institute for Lung Health, Justus Liebig University, Giessen, Germany.
Marielle Breau *Marseille Cancer Research Centre (CRCM), U1068 INSERM, UMR7258 CNRS, UM105 Aix-Marseille University, Institut Paoli-Calmettes, Ligue Nationale Contre le Cancer (Equipe labellisée), Team Telomeres and Chromatin, Marseille, France.
Christelle CayrouMarseille Cancer Research Centre (CRCM), U1068 INSERM, UMR7258 CNRS, UM105 Aix-Marseille University, Institut Paoli-Calmettes, Ligue Nationale Contre le Cancer (Equipe labellisée), Team Telomeres and Chromatin, Marseille, France.ORCID 0000-0002-6910-8023
Dmitri ChurikovMarseille Cancer Research Centre (CRCM), U1068 INSERM, UMR7258 CNRS, UM105 Aix-Marseille University, Institut Paoli-Calmettes, Ligue Nationale Contre le Cancer (Equipe labellisée), Team Telomeres and Chromatin, Marseille, France.ORCID 0000-0003-1127-8852
Laura BraudMarseille Cancer Research Centre (CRCM), U1068 INSERM, UMR7258 CNRS, UM105 Aix-Marseille University, Institut Paoli-Calmettes, Ligue Nationale Contre le Cancer (Equipe labellisée), Team Telomeres and Chromatin, Marseille, France.ORCID 0000-0002-8958-3817
Juliette JacquetInstitute for Lung Health, Justus Liebig University, Giessen, Germany.
Emmanuelle BornInstitute for Lung Health, Justus Liebig University, Giessen, Germany.ORCID 0000-0002-0557-3727
Charles FouilladeInstitut Curie, Inserm U1021, CNRS UMR 3347, University Paris-Saclay, PSL Research University, Orsay, France.ORCID 0000-0003-2692-5645
Sandra Curras-AlonsoInstitut Curie, PSL Research University, CNRS UMR3244, Sorbonne Université, Telomeres and Cancer, 75005, Paris, France.
Serge BauwensUniversité Côte d'Azur, CNRS, Inserm, IRCAN, Faculty of Medicine, Nice, France.
Frederic JourquinMarseille Cancer Research Centre (CRCM), U1068 INSERM, UMR7258 CNRS, UM105 Aix-Marseille University, Institut Paoli-Calmettes, Ligue Nationale Contre le Cancer (Equipe labellisée), Team Telomeres and Chromatin, Marseille, France.ORCID 0000-0001-6848-6973
Frederic FioreCentre d'Immunophénomique, Aix Marseille Université, INSERM, CNRS UMR, Marseille, France.ORCID 0000-0001-7955-6594
Rémy CastellanoMarseille Cancer Research Centre (CRCM), TrGET Preclinical Platform, Institut Paoli-Calmettes, Inserm, CNRS, Aix Marseille Université, Marseille, France.ORCID 0000-0002-0152-985X
Emmanuelle JosselinMarseille Cancer Research Centre (CRCM), TrGET Preclinical Platform, Institut Paoli-Calmettes, Inserm, CNRS, Aix Marseille Université, Marseille, France.
Carlota Sánchez-FerrerCentro Nacional de Investigaciones Cardiovasculares Carlos III, 28029, Madrid, Spain.
Giovanna GiovinazzoCentro Nacional de Investigaciones Cardiovasculares Carlos III, 28029, Madrid, Spain.
Christophe LachaudMarseille Cancer Research Centre (CRCM), U1068 INSERM, UMR7258 CNRS, UM105 Aix-Marseille University, Institut Paoli-Calmettes, Team DNA Interstrand Crosslink Lesions and Blood Disorders, Marseille, France.ORCID 0000-0003-2762-1619
Eric GilsonUniversité Côte d'Azur, CNRS, Inserm, IRCAN, Faculty of Medicine, Nice, France.ORCID 0000-0001-5738-6723
Ignacio FloresCentro Nacional de Investigaciones Cardiovasculares Carlos III, 28029, Madrid, Spain.
Arturo Londono-VallejoInstitut Curie, PSL Research University, CNRS UMR3244, Sorbonne Université, Telomeres and Cancer, 75005, Paris, France.ORCID 0000-0003-3535-7563
Serge AdnotInstitute for Lung Health, Justus Liebig University, Giessen, Germany. Serge.Adnot@innere.med.uni-giessen.de.ORCID 0000-0001-5666-3063
Vincent GéliMarseille Cancer Research Centre (CRCM), U1068 INSERM, UMR7258 CNRS, UM105 Aix-Marseille University, Institut Paoli-Calmettes, Ligue Nationale Contre le Cancer (Equipe labellisée), Team Telomeres and Chromatin, Marseille, France. vincent.geli@inserm.fr.ORCID 0000-0002-4103-7462
Centre National de la Recherche Scientifique · FRSpanish National Centre for Cardiovascular Research · ESInserm · FRJustus-Liebig-Universität Gießen · DE
Funding
CARCINOGEN-INDUCED GENETIC ALTERATIONS IN ANIMAL CELLSF32CA007524 · NCI · UNIVERSITY OF MIAMI SCHOOL OF MEDICINE · PI MONTELONE, BETH A · 1985 to 1985
–MARIHUANA EFFECTS ON TESTIS AND BEHAVIOR IN MICER01DA003875 · NIDA · SOUTHERN ILLINOIS UNIVERSITY CARBONDALE · PI BARTKE, ANDRZEJ · 1985 to 1988
–Canceropôle PACA (Canceropole PACA) Projet EmergentComunidad de Madrid (Community of Madrid) S2017/BMD-3875Fondation ARC pour la Recherche sur le Cancer (ARC) Projet ARCInstitut National de la Santé et de la Recherche Médicale (Inserm) AGEMEDInstitut National Du Cancer (INCa) PLBIO2019Ligue Contre le Cancer (French League Against Cancer) Comité Paris RS21/75-24Ligue Contre le Cancer (French League Against Cancer) Equipe LabelliséeMinisterio de Ciencia e Innovación (MCIN) PID2019-110339RB-I00PHENOMIN (French National Infrastructure for Mouse Phenogenomics) ANR10-INBS-07
Abstract
Lung diseases develop when telomeres shorten beyond a critical point. We constructed a mouse model in which the catalytic subunit of telomerase (mTert), or its catalytically inactive form (mTert
Indexed as
EmphysemaMicrovascular RarefactionPulmonary EmphysemaTelomeraseAnimalsMiceTelomere ShorteningTelomeraseCapillary DensityEmphysemap21SenescenceTelomerase
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.