Evidence map›Paper›PMID 38424154›Full record

ArticleCommunications chemistry2024

Sequestration within peptide coacervates improves the fluorescence intensity, kinetics, and limits of detection of dye-based DNA biosensors.

Christopher M Green, Deborah Sementa, Divita Mathur, Joseph S Melinger, Priyasha Deshpande, Shana Elbaum-Garfinkle, Igor L Medintz, Rein V Ulijn, Sebastián A Díaz

Open access · goldAbstract read
In one paragraph

Article in Communications chemistry, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
4.3field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 24 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Recent Advances in Reactive Microdroplets for Clean Water and Energy.Advanced materials (Deerfield Beach, Fla.) · 2025
    Review
  5. Review
  6. Article
  7. Article
  8. Article
  9. Review
  10. Coacervation in systems chemistry.Communications chemistry · 2024
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 1 country.

Christopher M Green *Center for Bio/Molecular Science and Engineering Code 6900, U.S. Naval Research Laboratory, Washington, DC, 20375, USA.
Deborah Sementa *Nanoscience Initiative at Advanced Science Research Center, Graduate Center of the City University of New York, New York, NY, 10031, USA.ORCID http://orcid.org/0009-0007-6338-7598
Divita MathurDepartment of Chemistry, Case Western Reserve University, Cleveland, OH, 44106, USA.ORCID http://orcid.org/0000-0002-3537-7292
Joseph S MelingerElectronics Sciences and Technology Division Code 6816, U.S. Naval Research Laboratory, Washington, DC, 20375, USA.
Priyasha DeshpandeStructural Biology Initiative at Advanced Science Research Center, Graduate Center of the City University of New York, New York, NY, 10031, USA.
Shana Elbaum-GarfinkleStructural Biology Initiative at Advanced Science Research Center, Graduate Center of the City University of New York, New York, NY, 10031, USA.ORCID http://orcid.org/0000-0002-3953-7329
Igor L MedintzCenter for Bio/Molecular Science and Engineering Code 6900, U.S. Naval Research Laboratory, Washington, DC, 20375, USA.
Rein V UlijnNanoscience Initiative at Advanced Science Research Center, Graduate Center of the City University of New York, New York, NY, 10031, USA.
Sebastián A DíazCenter for Bio/Molecular Science and Engineering Code 6900, U.S. Naval Research Laboratory, Washington, DC, 20375, USA. sebastian.diaz@nrl.navy.mil.ORCID http://orcid.org/0000-0002-5568-0512
The Graduate Center, CUNY · USUnited States Naval Research Laboratory · USCase Western Reserve University · US

Funding

Cytosolic Access and Instability of DNA nanoparticlesR00EB030013 · NIBIB · CASE WESTERN RESERVE UNIVERSITY · PI MATHUR, DIVITA · 2022 to 2024
$747k
NIBIB NIH HHS R00 EB030013
6 · The paper itself

Abstract

Peptide-based liquid-liquid phase separated domains, or coacervates, are a biomaterial gaining new interest due to their exciting potential in fields ranging from biosensing to drug delivery. In this study, we demonstrate that coacervates provide a simple and biocompatible medium to improve nucleic acid biosensors through the sequestration of both the biosensor and target strands within the coacervate, thereby increasing their local concentration. Using the well-established polyarginine (R

Identifiers

PMID38424154
PMCPMC10904739
OpenAlexW4392282710

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.