ArticleMolecular psychiatry2024
Perception of social inclusion/exclusion and response inhibition in adolescents with past suicide attempt: a multidomain task-based fMRI study.
Article in Molecular psychiatry, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 2 of them syntheses that pooled it.
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Who cites it
11 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Neural mechanisms of suicide thoughts and behaviors in major depressive disorder: abnormal regional brain activity and its functional connectivity.BMC psychiatry · 2025Pooled it
- Experimental investigations of social exclusion among adolescents with psychiatric disorders: a systematic review.European child & adolescent psychiatry · 2025Pooled it
- Differential neural activation during reward processing in preadolescent suicidal ideation.Child psychiatry and human development · 2026Article
- Brain Functional Network Alterations in Adolescents With Major Depressive Disorder and Suicidal Attempt: A Resting-State fMRI Study.Alpha psychiatry · 2026Article
- Understanding the emergence of suicidal thoughts and behaviors in adolescence from a brain and behavioral developmental perspective.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2026Review
- Effects of Cyberball on cognitive vulnerability for suicide in youth with a history of multiple suicide attempts.Frontiers in psychiatry · 2026Article
- Review: Suicide and its relationship to aggression and impulsivity.Cognitive, affective & behavioral neuroscience · 2025Review
- Facial Temperature Responses to Ostracism in Women: Exploring Nasal Thermal Signatures of Different Coping Behaviors.Psychophysiology · 2025Article
- Article
- Analysis of the traits of deliberate substance abuse and its correlation with psychological states in adolescents.Frontiers in psychiatry · 2025Article
- Neural correlates of decision making and executive function in suicidal thoughts and behaviors.Frontiers in psychiatry · 2025Review
Corrections and comments
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Authors and funding
11 authors.
Funding
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Abstract
The occurrence of suicidal behaviors increases during adolescence. Hypersensitivity to negative social signals and deficits in cognitive control are putative mechanisms of suicidal behaviors, which necessitate confirmation in youths. Multidomain functional neuroimaging could enhance the identification of patients at suicidal risk beyond standard clinical measures. Three groups of adolescents (N = 96; 78% females, age = 11.6-18.1) were included: patients with depressive disorders and previous suicide attempts (SA, n = 29); patient controls with depressive disorders but without any suicide attempt history (PC, n = 35); and healthy controls (HC, n = 32). We scanned participants with 3T-MRI during social inclusion/exclusion (Cyberball Game) and response inhibition (Go-NoGo) tasks. Neural activation was indexed by the blood-oxygenation-level dependent (BOLD) of the hemodynamic response during three conditions in the Cyberball Game ("Control condition", "Social Inclusion", and "Social Exclusion"), and two conditions in Go-NoGo task ("Go" and "NoGo" blocks). ANCOVA-style analysis identified group effects across three whole-brain contrasts: 1) NoGo vs. Go, 2) Social inclusion vs. control condition, 3) Social exclusion vs. control condition. We found that SA had lower activation in the left insula during social inclusion vs. control condition compared to PC and HC. Moreover, SA compared to PC had higher activity in the right middle prefrontal gyrus during social exclusion vs. control condition, and in bilateral precentral gyri during NoGo vs. Go conditions. Task-related behavioral and self-report measures (Self-reported emotional reactivity in the Cyberball Game, response times and number of errors in the Go-NoGo Task) did not discriminate groups. In conclusion, adolescent suicidal behaviors are likely associated with neural alterations related to the processing of social perception and response inhibition. Further research, involving prospective designs and diverse cohorts of patients, is necessary to explore the potential of neuroimaging as a tool in understanding the emergence and progression of suicidal behaviors.
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