Evidence map›Paper›PMID 38424079›Full record

ArticleScientific data2024

A large open access dataset of brain metastasis 3D segmentations on MRI with clinical and imaging information.

Divya Ramakrishnan, Leon Jekel, Saahil Chadha, Anastasia Janas, Harrison Moy, Nazanin Maleki, Matthew Sala, Manpreet Kaur, Gabriel Cassinelli Petersen, Sara Merkaj and 12 more

Abstract readDataset
In one paragraph

Article in Scientific data, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed.

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  19. Morphological MRI features as prognostic indicators in brain metastases.Cancer imaging : the official publication of the International Cancer Imaging Society · 2024
    Article
  20. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

22 authors.

Divya RamakrishnanYale School of Medicine, Department of Radiology and Biomedical Imaging, New Haven, CT, USA. divya.ramakrishnan@yale.edu.ORCID 0000-0003-2581-1793
Leon JekelYale School of Medicine, Department of Radiology and Biomedical Imaging, New Haven, CT, USA.ORCID 0000-0001-9954-3328
Saahil ChadhaYale School of Medicine, Department of Radiology and Biomedical Imaging, New Haven, CT, USA.
Anastasia JanasYale School of Medicine, Department of Radiology and Biomedical Imaging, New Haven, CT, USA.
Harrison MoyYale School of Medicine, Department of Radiology and Biomedical Imaging, New Haven, CT, USA.
Nazanin MalekiYale School of Medicine, Department of Radiology and Biomedical Imaging, New Haven, CT, USA.
Matthew SalaYale School of Medicine, Department of Radiology and Biomedical Imaging, New Haven, CT, USA.
Manpreet KaurYale School of Medicine, Department of Radiology and Biomedical Imaging, New Haven, CT, USA.
Gabriel Cassinelli PetersenYale School of Medicine, Department of Radiology and Biomedical Imaging, New Haven, CT, USA.
Sara MerkajYale School of Medicine, Department of Radiology and Biomedical Imaging, New Haven, CT, USA.
Marc von ReppertYale School of Medicine, Department of Radiology and Biomedical Imaging, New Haven, CT, USA.
Ujjwal BaidDivision of Computational Pathology, Department of Pathology & Laboratory Medicine, Indiana University School of Medicine, Indianapolis, IN, USA.
Spyridon BakasDivision of Computational Pathology, Department of Pathology & Laboratory Medicine, Indiana University School of Medicine, Indianapolis, IN, USA.ORCID 0000-0001-8734-6482
Claudia KirschYale School of Medicine, Department of Radiology and Biomedical Imaging, New Haven, CT, USA.
Melissa DavisYale School of Medicine, Department of Radiology and Biomedical Imaging, New Haven, CT, USA.
Khaled BousabarahVisage Imaging, GmbH, Berlin, Germany.
Wolfgang HollerVisage Imaging, GmbH, Berlin, Germany.
MingDe LinYale School of Medicine, Department of Radiology and Biomedical Imaging, New Haven, CT, USA.
Malte WesterhoffVisage Imaging, GmbH, Berlin, Germany.
Sanjay AnejaDepartment of Therapeutic Radiology, Yale School of Medicine, New Haven, CT, USA.
Fatima MemonYale School of Medicine, Department of Radiology and Biomedical Imaging, New Haven, CT, USA.
Mariam S AboianYale School of Medicine, Department of Radiology and Biomedical Imaging, New Haven, CT, USA.

Funding

Yale Clinical and Translational Science Award (U Component)UL1TR001863 · NCATS · YALE UNIVERSITY · PI John H. Krystal, LUCILA OHNO-MACHADO · 2016 to 2026
$102.9M
The Federated Tumor Segmentation (FeTS) platform: An intuitive tool facilitating secure multi-institutional collaborationU01CA242871 · NCI · UNIVERSITY OF PENNSYLVANIA · PI BAKAS, SPYRIDON · 2019 to 2021
$1.1M
NCATS NIH HHS UL1 TR001863NCI NIH HHS U01 CA242871
6 · The paper itself

Abstract

Resection and whole brain radiotherapy (WBRT) are standard treatments for brain metastases (BM) but are associated with cognitive side effects. Stereotactic radiosurgery (SRS) uses a targeted approach with less side effects than WBRT. SRS requires precise identification and delineation of BM. While artificial intelligence (AI) algorithms have been developed for this, their clinical adoption is limited due to poor model performance in the clinical setting. The limitations of algorithms are often due to the quality of datasets used for training the AI network. The purpose of this study was to create a large, heterogenous, annotated BM dataset for training and validation of AI models. We present a BM dataset of 200 patients with pretreatment T1, T1 post-contrast, T2, and FLAIR MR images. The dataset includes contrast-enhancing and necrotic 3D segmentations on T1 post-contrast and peritumoral edema 3D segmentations on FLAIR. Our dataset contains 975 contrast-enhancing lesions, many of which are sub centimeter, along with clinical and imaging information. We used a streamlined approach to database-building through a PACS-integrated segmentation workflow.

Indexed as

Brain NeoplasmsArtificial IntelligenceCranial IrradiationHumansMagnetic Resonance ImagingRadiosurgery

Identifiers

PMID38424079
PMCPMC10904366

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.