Evidence map›Paper›PMID 38424039›Full record

ArticleNature communications2024

Magnetically driven capsules with multimodal response and multifunctionality for biomedical applications.

Yuxuan Sun, Wang Zhang, Junnan Gu, Liangyu Xia, Yinghao Cao, Xinhui Zhu, Hao Wen, Shaowei Ouyang, Ruiqi Liu, Jialong Li and 9 more

Registry-linked trialAbstract read
In one paragraph

Article in Nature communications, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06848400 (A Multicenter, Prospective Study of Capsule Gastric Endoscopy for Gastric Disease Screening in Simulated Home Scenarios), which is not on this map. Cited by 34 papers.

0numbers the graph read from it
0cells of the map it votes in
34citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06848400 narecruitingnot on this mapstarted 2025, after this paper: background citation

A Multicenter, Prospective Study of Capsule Gastric Endoscopy for Gastric Disease Screening in Simulated Home Scenarios

TypeinterventionalSponsorNanfang Hospital, Southern Medical UniversityRan2025 to 2026Enrolled482ConditionsGastric Lesion, Gastritis, Upper Gastrointestinal Bleeding (UGIB), Gastric DysplasiaArmsAI-integrated Capsule Gastroscopy (ACG) examination, Electronic gastroduodenoscopy (EGD) examination
3 · Its place in the literature

Who cites it

34 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
  4. Review
  5. Miniature Soft Robot With Magnetically Reprogrammable Surgical Functions.Advanced materials (Deerfield Beach, Fla.) · 2026
    Article
  6. Article
  7. Review
  8. Article
  9. Article
  10. Review
  11. Review
  12. Article
  13. Magneto-X Effects in Magnetic Soft Materials and Their Applications.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026
    Review
  14. Article
  15. Article
  16. Article
  17. Article
  18. Article
  19. A Pill That Prints-An Ingestible Bioprinter for Non-Invasive Structured Bioink Deposition.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025
    Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors.

Yuxuan Sun *Wuhan National High Magnetic Field Center, Huazhong University of Science and Technology, Wuhan, 430074, China.ORCID 0000-0002-7057-3459
Wang Zhang *Wuhan National High Magnetic Field Center, Huazhong University of Science and Technology, Wuhan, 430074, China.
Junnan GuDepartment of Gastrointestinal Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022, China.
Liangyu XiaWuhan National High Magnetic Field Center, Huazhong University of Science and Technology, Wuhan, 430074, China.
Yinghao CaoCancer Center, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022, China.
Xinhui ZhuWuhan National High Magnetic Field Center, Huazhong University of Science and Technology, Wuhan, 430074, China.
Hao WenWuhan National High Magnetic Field Center, Huazhong University of Science and Technology, Wuhan, 430074, China.
Shaowei OuyangWuhan National High Magnetic Field Center, Huazhong University of Science and Technology, Wuhan, 430074, China.
Ruiqi LiuWuhan National High Magnetic Field Center, Huazhong University of Science and Technology, Wuhan, 430074, China.
Jialong LiWuhan National High Magnetic Field Center, Huazhong University of Science and Technology, Wuhan, 430074, China.
Zhenxing JiangDepartment of Gastrointestinal Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022, China.
Denglong ChengDepartment of Gastrointestinal Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022, China.
Yiliang LvWuhan National High Magnetic Field Center, Huazhong University of Science and Technology, Wuhan, 430074, China.
Xiaotao HanWuhan National High Magnetic Field Center, Huazhong University of Science and Technology, Wuhan, 430074, China.
Wu QiuSchool of Life Science and Technology, Huazhong University of Science and Technology, Wuhan, 430074, China.
Kailin CaiDepartment of Gastrointestinal Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022, China.
Enmin SongSchool of Computer and Technology, Huazhong University of Science and Technology, Wuhan, 430074, China.
Quanliang CaoWuhan National High Magnetic Field Center, Huazhong University of Science and Technology, Wuhan, 430074, China. quanliangcao@hust.edu.cn.ORCID 0000-0003-3691-2311
Liang LiWuhan National High Magnetic Field Center, Huazhong University of Science and Technology, Wuhan, 430074, China. liangli44@hust.edu.cn.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Untethered capsules hold clinical potential for the diagnosis and treatment of gastrointestinal diseases. Although considerable progress has been achieved recently in this field, the constraints imposed by the narrow spatial structure of the capsule and complex gastrointestinal tract environment cause many open-ended problems, such as poor active motion and limited medical functions. In this work, we describe the development of small-scale magnetically driven capsules with a distinct magnetic soft valve made of dual-layer ferromagnetic soft composite films. A core technological advancement achieved is the flexible opening and closing of the magnetic soft valve by using the competitive interactions between magnetic gradient force and magnetic torque, laying the foundation for the functional integration of both drug release and sampling. Meanwhile, we propose a magnetic actuation strategy based on multi-frequency response control and demonstrate that it can achieve effective decoupled regulation of the capsule's global motion and local responses. Finally, through a comprehensive approach encompassing ideal models, animal ex vivo models, and in vivo assessment, we demonstrate the versatility of the developed magnetic capsules and their multiple potential applications in the biomedical field, such as targeted drug delivery and sampling, selective dual-drug release, and light/thermal-assisted therapy.

Indexed as

Drug Delivery SystemsGastrointestinal DiseasesAnimalsPhysical Phenomena

Identifiers

PMID38424039
PMCPMC10904804

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.