Evidence map›Paper›PMID 38423764›Full record

ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2024

Encoding of Predictive Associations in Human Prefrontal and Medial Temporal Neurons During Pavlovian Appetitive Conditioning.

Tomas G Aquino, Hristos Courellis, Adam N Mamelak, Ueli Rutishauser, John P O Doherty

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
1.7field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 5 citations in OpenAlex.

  1. Article
  2. Review
  3. Consistent Hierarchies of Single-Neuron Timescales in Mice, Macaques, and Humans.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025
    Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Tomas G AquinoDepartment of Neurosurgery, Cedars-Sinai Medical Center, Los Angeles, California 90048 tg2863@columbia.edu.
Hristos CourellisBiological Engineering, Division of Biology and Biological Engineering, California Institute of Technology, Pasadena, California 91125.
Adam N MamelakDepartment of Neurosurgery, Cedars-Sinai Medical Center, Los Angeles, California 90048.
Ueli RutishauserDepartment of Neurosurgery, Cedars-Sinai Medical Center, Los Angeles, California 90048.ORCID 0000-0002-9207-7069
John P O DohertyComputation and Neural Systems, Division of Biology and Biological Engineering, California Institute of Technology, Pasadena, California 91125.
California Institute of Technology · USCedars-Sinai Medical Center · US

Funding

The Neurobiology of Social Decision-Making: Social Inference and ContextP50MH094258 · NIMH · CALIFORNIA INSTITUTE OF TECHNOLOGY · PI ANDERSEN, RICHARD A · 2012 to 2021
$18.6M
Neuronal mechanisms of human episodic memoryU01NS117839 · NINDS · CEDARS-SINAI MEDICAL CENTER · PI MAMELAK, ADAM NATHANIEL, RUTISHAUSER, UELI · 2020 to 2024
$7.8M
Determining the neural substrates of model-based and model-free reinforcement-learning during Pavlovian conditioning (Minority Supplement)R01DA040011 · NIDA · CALIFORNIA INSTITUTE OF TECHNOLOGY · PI O'DOHERTY, JOHN P · 2016 to 2020
$2.6M
Probing the neural computations underlying goal-directed decision-making in humans with single-neuron recordingsR01MH133729 · NIMH · CALIFORNIA INSTITUTE OF TECHNOLOGY · PI O'DOHERTY, JOHN P, RUTISHAUSER, UELI · 2023 to 2024
$862k
Role of the X-chromosome in Pulmonary Arterial HypertensionR03HL110831 · NHLBI · CLEVELAND CLINIC LERNER COM-CWRU · PI ALDRED, MICHEALA A · 2011 to 2012
$157k
NHLBI NIH HHS R03 HL110831NIDA NIH HHS R01 DA040011NIMH NIH HHS P50 MH094258NIMH NIH HHS R01 MH133729NINDS NIH HHS U01 NS117839
6 · The paper itself

Abstract

Pavlovian conditioning is thought to involve the formation of learned associations between stimuli and values, and between stimuli and specific features of outcomes. Here, we leveraged human single neuron recordings in ventromedial prefrontal, dorsomedial frontal, hippocampus, and amygdala while patients of both sexes performed an appetitive Pavlovian conditioning task probing both stimulus-value and stimulus-stimulus associations. Ventromedial prefrontal cortex encoded predictive value along with the amygdala, and also encoded predictions about the identity of stimuli that would subsequently be presented, suggesting a role for neurons in this region in encoding predictive information beyond value. Unsigned error signals were found in dorsomedial frontal areas and hippocampus, potentially supporting learning of non-value related outcome features. Our findings implicate distinct human prefrontal and medial temporal neuronal populations in mediating predictive associations which could partially support model-based mechanisms during Pavlovian conditioning.

Indexed as

Conditioning, ClassicalNeuronsPrefrontal CortexAdultAppetitive BehaviorAssociation LearningFemaleHumansMaleTemporal LobeYoung Adultamygdalahuman single neuronsintracranial recordingsPavlovian conditioningReinforcement learningvmPFC

Identifiers

PMID38423764
PMCPMC11044193
OpenAlexW4392283263

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.