Trial reportThe European respiratory journal2024
The effect of high altitude (2500 m) on incremental cycling exercise in patients with pulmonary arterial hypertension and chronic thromboembolic pulmonary hypertension: a randomised controlled crossover trial.
Trial report in The European respiratory journal, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
13 citing papers in PubMed, 14 citations in OpenAlex.
- Pulmonary haemodynamics and right heart function during exercise at high versus low altitude in patients with pulmonary vascular disease: a randomised crossover trial.Heart (British Cardiac Society) · 2025Trial
- Effect of sildenafil on resting and exercise haemodynamics in hypoxia in patients with pulmonary vascular diseases: data from a randomised controlled trial.ERJ open research · 2026Article
- Iron Homeostasis at High Altitude in Patients With Pulmonary Hypertension.Pulmonary circulation · 2026Article
- Nocturnal Cerebral Oxygenation in Low-Altitude Residents With Pulmonary Vascular Disease Staying Overnight at High Altitude. Data From a Randomized, Controlled, Crossover Trial.Pulmonary circulation · 2026Article
- The effect of high altitude on exercise capacity and cardiorespiratory function in patients with pulmonary vascular disease after an overnight stay at 2500 m: a randomised crossover study.ERJ open research · 2026Article
- Exercise in acute and subacute hypoxic conditions: physiological responses affecting oxygen delivery and their applications to human health.The Journal of physiology · 2026Review
- Hypertension Prevalence Among People Lifted Out of Poverty in China in 2018-2023: Retrospective Spatiotemporal Analysis.JMIR public health and surveillance · 2025Article
- Long-term maternal and fetal outcomes of pulmonary hypertension in pregnancy in the southwest plateau area of China: a retrospective study.BMC pulmonary medicine · 2025Article
- Effect of Normobaric Hypoxia on Invasive Exercise Hemodynamics in Patients with Pulmonary Vascular Disease: A Randomized Controlled Trial.American journal of respiratory and critical care medicine · 2025Article
- PVRI International Conference 2025: Embracing Heterogeneity.Pulmonary circulation · 2025Article
- Peak Eccentric Cycling Exercise and Cardiorespiratory Responses to Normobaric Hypoxia Versus Normobaric Normoxia in Healthy Adults: A Randomized, Controlled Crossover Trial.Journal of clinical medicine · 2025Article
- Differences in Exercise Capacity, Ventilatory Efficiency, and Gas Exchange between Patients with Pulmonary Arterial Hypertension and Chronic Thromboembolic Pulmonary Hypertension Residing at High Altitude.Reviews in cardiovascular medicine · 2024Article
- Survival rates at one and five years for patients with group 1 pulmonary arterial hypertension at high altitude: A retrospective cohort study.Science progressArticle
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Authors and funding
13 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundOur objective was to investigate the effect of a day-long exposure to high altitude on peak exercise capacity and safety in stable patients with pulmonary arterial hypertension (PAH) and chronic thromboembolic pulmonary hypertension (CTEPH).
methodsIn a randomised controlled crossover trial, stable patients with PAH or distal CTEPH without resting hypoxaemia at low altitude performed two incremental exercise tests to exhaustion: one after 3-5 h at high altitude (2500 m) and one at low altitude (470 m).
resultsIn 27 patients with PAH/CTEPH (44% females, mean±sd age 62±14 years), maximal work rate was 110±64 W at 2500 m and 123±64 W at 470 m (-11%, 95% CI -16- -11%; p<0.001). Oxygen saturation measured by pulse oximetry and arterial oxygen tension at end-exercise were 83±6%
conclusionsAmong predominantly low-risk patients with stable PAH/CTEPH, cycling exercise during the first day at 2500 m was well tolerated, but peak exercise capacity, blood oxygenation and ventilatory efficiency were lower compared with 470 m.
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