Evidence map›Paper›PMID 38423547›Full record

Trial reportBMJ global health2024

Impact of topical applications of sunflower seed oil on neonatal mortality and morbidity in southern Nepal: a community-based, cluster-randomised trial.

Joanne Katz, Subarna K Khatry, Laxman Shrestha, Aimee Summers, Marty O Visscher, Jeevan B Sherchand, James M Tielsch, Seema Subedi, Steven C LeClerq, Luke C Mullany

Registry-linked trialOpen access · goldAbstract readMulticenter StudyRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in BMJ global health, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01177111 (Impact of Sunflower Seed Oil Massage on Neonatal Mortality and Morbidity in Nepal), which is not on this map. Cited by 3 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed, 1 pooled it
2.6field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT01177111 phase3completednot on this map

Impact of Sunflower Seed Oil Massage on Neonatal Mortality and Morbidity in Nepal

TypeinterventionalSponsorJohns Hopkins Bloomberg School of Public HealthRan2010 to 2017Enrolled29,260ConditionsNeonatal Mortality, Neonatal SepsisArmsSunflower seed oil, Mustard seed oil
3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 1 synthesis or guideline pooled it, 3 citations in OpenAlex.

  1. Pooled it
  2. Trial
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 5 institutions in 2 countries.

Joanne KatzDepartment of International Health, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, USA jkatz1@jhu.edu.ORCID http://orcid.org/0000-0002-5997-7823
Subarna K KhatryNepal Nutrition Intervention Project, Kathmandu, Nepal.
Laxman ShresthaInstitute of Medicine, Tribhuvan University, Kirtipur, Nepal.
Aimee SummersDepartment of International Health, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, USA.
Marty O VisscherCincinnati Children's Hospital Medical Center, Cincinnati, Ohio, USA.
Jeevan B SherchandTribhuvan University, Kirtipur, Nepal.
James M TielschGlobal Health, George Washington University School of Public Health and Health Services, Washington, District of Columbia, USA.
Seema SubediDepartment of International Health, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, USA.
Steven C LeClerqDepartment of International Health, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, USA.
Luke C MullanyDepartment of International Health, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, USA.
Johns Hopkins University · USTribhuvan University · NPCincinnati Children's Hospital Medical Center · USGeorge Washington University · USNLR Nepal · NP

Funding

Impact of Sunflower Oil Massage on Neonatal Mortality in NepalR01HD060712 · NICHD · JOHNS HOPKINS UNIVERSITY · PI MULLANY, LUKE C · 2009 to 2013
$2.9M
Prioritization of modifiable risk factors for adverse pregnancy outcomes and neonatal mortality in rural NepalR01HD092411 · NICHD · JOHNS HOPKINS UNIVERSITY · PI KATZ, JOANNE · 2018 to 2020
$822k
NICHD NIH HHS R01 HD060712NICHD NIH HHS R01 HD092411
6 · The paper itself

Abstract

introductionHospital-based studies have demonstrated topical applications of sunflower seed oil (SSO) to skin of preterm infants can reduce nosocomial infections and improve survival. In South Asia, replacing traditional mustard with SSO might have similar benefits.

methods340 communities in Sarlahi, Nepal were randomised to use mustard oil (MO) or SSO for community practice of daily newborn massage. Women were provided oil in late pregnancy and the first month post partum, and visited daily through the first week of life to encourage massage practice. A separate data collection team visited on days 1, 3, 7, 10, 14, 21 and 28 to record vital status and assess serious bacterial infection.

resultsBetween November 2010 and January 2017, we enrolled 39 479 pregnancies. 32 114 live births were analysed. Neonatal mortality rates (NMRs) were 31.8/1000 (520 deaths, 16 327 births) and 30.5/1000 (478 deaths, 15 676 births) in control and intervention, respectively (relative risk (RR)=0.95, 95% CI: 0.84, 1.08). Among preterm births, NMR was 90.4/1000 (229 deaths, 2533 births) and 79.2/1000 (188 deaths, 2373 births) in control and intervention, respectively (RR=0.88; 95% CI: 0.74, 1.05). Among preterm births <34 weeks, the RR was 0.83 (95% CI: 0.67, 1.02). No statistically significant differences were observed in incidence of serious bacterial infection.

conclusionsWe did not find any neonatal mortality or morbidity benefit of using SSO instead of MO as emollient therapy in the early neonatal period. Further studies examining whether very preterm babies may benefit are warranted. TRIAL REGISTRATION NUMBER: ClinicalTrials.gov Registry (NCT01177111).

Indexed as

Bacterial InfectionsPremature BirthFemaleHumansInfantInfant MortalityInfant, NewbornInfant, PrematureMorbidityNepalPregnancySunflower OilSunflower OilChild healthCluster randomized trialPaediatrics

Identifiers

PMID38423547
PMCPMC10910473
OpenAlexW4392303097

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.