Evidence map›Paper›PMID 38423390›Full record

ArticleMucosal immunology2024

Mechanotransduction-induced interplay between phospholamban and yes-activated protein induces smooth muscle cell hypertrophy.

Renee Rawson, Loan Duong, Eugene Tkachenko, Austin W T Chiang, Kevin Okamoto, Ranjan Dohil, Nathan E Lewis, Richard Kurten, Edsel M Abud, Seema S Aceves

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Mucosal immunology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
1.3field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 4 citations in OpenAlex.

  1. Prostaglandin EbioRxiv : the preprint server for biology · 2026
    Article
  2. Article
  3. Muscular hyperplasia in Crohn's disease strictures: through thick and thin.American journal of physiology. Cell physiology · 2024
    Review
  4. Development and dysfunction of structural cells in eosinophilic esophagitis.The Journal of allergy and clinical immunology · 2024
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 4 institutions in 1 country.

Renee RawsonDepartment of Pediatrics, University of California, San Diego, California; Division of Allergy Immunology, University of California, San Diego, California.
Loan DuongDepartment of Pediatrics, University of California, San Diego, California; Division of Allergy Immunology, University of California, San Diego, California.
Eugene TkachenkoDepartment of Pediatrics, University of California, San Diego, California; Division of Allergy Immunology, University of California, San Diego, California; Department of Medicine, University of California, San Diego, California.
Austin W T ChiangDepartment of Pediatrics, University of California, San Diego, California; Department of Bioengineering, University of California, San Diego, California.
Kevin OkamotoDepartment of Pediatrics, University of California, San Diego, California; Division of Allergy Immunology, University of California, San Diego, California.
Ranjan DohilDepartment of Pediatrics, University of California, San Diego, California; Division of Gastroenterology, University of California, San Diego, California; XXX, Rady Children's Hospital, San Diego, California.
Nathan E LewisDepartment of Pediatrics, University of California, San Diego, California; Department of Bioengineering, University of California, San Diego, California.
Richard KurtenDepartment of Physiology and Biophysics, University of Arkansas for Medical Sciences, Arkansas Children's Hospital Research Institute, Little Rock, Arkansas; Department of Pediatrics, University of California, San Diego, California; Division of Allergy Immunology, University of California, San Diego, California.
Edsel M AbudDepartment of Pediatrics, University of California, San Diego, California; Division of Allergy Immunology, University of California, San Diego, California; XXX, Scripps Research Translational Institute, Scripps Research, San Diego, California.
Seema S AcevesDepartment of Pediatrics, University of California, San Diego, California; Division of Allergy Immunology, University of California, San Diego, California; XXX, Rady Children's Hospital, San Diego, California; Department of Medicine, University of California, San Diego, California. Electronic address: saceves@health.ucsd.edu.
University of California San Diego · USUniversity of California System · USArkansas Children's Hospital · USScripps Research Institute · US

Funding

UC San Diego Clinical and Translational Research InstituteUL1TR001442 · NCATS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI FIRESTEIN, GARY S, HOGARTH, MICHAEL · 2015 to 2024
$88.3M
Institutional Career Development CoreKL2TR002552 · NCATS · SCRIPPS RESEARCH INSTITUTE, THE · PI NICHOLSON, LAURA · 2018 to 2022
$5.2M
Mechanisms of tissue damage leading to chronic allergic eosinophilic esophagitisR01AI092135 · NIAID · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI ACEVES, SEEMA S · 2011 to 2020
$4.4M
Unraveling the mammalian secretory pathway through systems biology and algorithm developmentR35GM119850 · NIGMS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI LEWIS, NATHAN ENOCH · 2016 to 2025
$4.3M
CTSA K12 Program at The Scripps Research InstituteK12TR004410 · NCATS · SCRIPPS RESEARCH INSTITUTE, THE · PI Laura Nicholson, Athena Philis-Tsimikas · 2023 to 2026
$3.9M
Mentoring Patient Oriented Research in Allergic Eosinophilic Gastrointestinal DisordersK24AI135034 · NIAID · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI ACEVES, SEEMA S · 2018 to 2022
$898k
NCATS NIH HHS K12 TR004410NCATS NIH HHS KL2 TR002552NCATS NIH HHS UL1 TR001442NIAID NIH HHS K24 AI135034NIAID NIH HHS R01 AI092135NIGMS NIH HHS R35 GM119850
6 · The paper itself

Abstract

The gastrointestinal system is a hollow organ affected by fibrostenotic diseases that cause volumetric compromise of the lumen via smooth muscle hypertrophy and fibrosis. Many of the driving mechanisms remain unclear. Yes-associated protein-1 (YAP) is a critical mechanosensory transcriptional regulator that mediates cell hypertrophy in response to elevated extracellular rigidity. In the type 2 inflammatory disorder, eosinophilic esophagitis (EoE), phospholamban (PLN) can induce smooth muscle cell hypertrophy. We used EoE as a disease model for understanding a mechanistic pathway in which PLN and YAP interact in response to rigid extracellular substrate to induce smooth muscle cell hypertrophy. PLN-induced YAP nuclear sequestration in a feed-forward loop caused increased cell size in response to a rigid substrate. This mechanism of rigidity sensing may have previously unappreciated clinical implications for PLN-expressing hollow systems such as the esophagus and heart.

Indexed as

Calcium-Binding ProteinsHypertrophyMechanotransduction, CellularMyocytes, Smooth MuscleYAP-Signaling ProteinsAdaptor Proteins, Signal TransducingAnimalsHumansMicePhospholambanTranscription FactorsAdaptor Proteins, Signal TransducingCalcium-Binding ProteinsPhospholambanTranscription FactorsYAP-Signaling Proteins

Identifiers

PMID38423390
PMCPMC11195688
OpenAlexW4392184702

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.