ArticleThe Journal of allergy and clinical immunology2024
Early-life nasal microbiota dynamics relate to longitudinal respiratory phenotypes in urban children.
Article in The Journal of allergy and clinical immunology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
What it found
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Who cites it
7 citing papers in PubMed, 11 citations in OpenAlex.
- Composition and dynamics of the adult nasal microbiome.Microbiome · 2026Article
- The nasal-oral microbiome axis in allergic rhinitis: environmental triggers, microbial dysbiosis, and immune dysregulation.Frontiers in allergy · 2026Review
- Non-pharmaceutical interventions restructured the upper respiratory bacterial microbiota in children under 2 during COVID-19: implications for infection control strategies.Frontiers in microbiology · 2026Article
- The effect of developmental stages on microbiome assembly in the phyllosphere and rhizosphere of rice grown in urban area soil.Environmental microbiome · 2025Article
- Respiratory Microbiota and Health Risks in Children with Cerebral Palsy: A Narrative Review.Children (Basel, Switzerland) · 2025Review
- Microbial influencers: the airway microbiome's role in asthma.The Journal of clinical investigation · 2025Review
- Microbial Buffer? The Human Lung Microbiome and Immune Responses to Diesel Exhaust.Environmental health perspectives · 2024Article
Corrections and comments
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Authors and funding
21 authors at 9 institutions in 1 country.
Funding
Abstract
backgroundFive distinct respiratory phenotypes based on latent classes of longitudinal patterns of wheezing, allergic sensitization. and pulmonary function measured in urban children from ages from 0 to 7 years have previously been described.
objectiveOur aim was to determine whether distinct respiratory phenotypes are associated with early-life upper respiratory microbiota development and environmental microbial exposures.
methodsMicrobiota profiling was performed using 16S ribosomal RNA-based sequencing of nasal samples collected at age 12 months (n = 120) or age 36 months (n = 142) and paired house dust samples collected at 3 months (12-month, n = 73; 36-month, n = 90) from all 4 centers in the Urban Environment and Childhood Asthma (URECA) cohort.
resultsIn these high-risk urban children, nasal microbiota increased in diversity between ages 12 and 36 months (ß = 2.04; P = .006). Age-related changes in microbiota evenness differed significantly by respiratory phenotypes (interaction P = .0007), increasing most in the transient wheeze group. At age 12 months, respiratory illness (R
conclusionNasal microbiota development over the course of early childhood and composition at age 3 years are associated with longitudinal respiratory phenotypes. These data provide evidence supporting an early-life window of airway microbiota development that is influenced by environmental microbial exposures in infancy and associates with wheeze- and atopy-associated respiratory phenotypes through age 7 years.
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Registered trials
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