Evidence map›Paper›PMID 38423263›Full record

ArticleNeuroImage2024

A novel restrainer device for acquistion of brain images in awake rats.

Jakov Tiefenbach, Logan Shannon, Mark Lobosky, Sadie Johnson, Hugh H Chan, Nicole Byram, Andre G Machado, Charlie Androjna, Kenneth B Baker

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in NeuroImage, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact, top 97% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 0 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Jakov TiefenbachDepartment of Neuroscience, Lerner Research Institute, Cleveland Clinic, OH 44195, USA. Electronic address: Tiefenj2@ccf.org.
Logan ShannonEngineering Core, Lerner Research Institute, Cleveland Clinic, OH 44195, USA.
Mark LoboskySmall Animal Imaging Core, Lerner Research Institute, Cleveland Clinic, OH 44195, USA.
Sadie JohnsonEngineering Core, Lerner Research Institute, Cleveland Clinic, OH 44195, USA.
Hugh H ChanDepartment of Neuroscience, Lerner Research Institute, Cleveland Clinic, OH 44195, USA.
Nicole ByramCleveland Clinic Innovations, Cleveland Clinic, OH 44195, USA.
Andre G MachadoDepartment of Neuroscience, Lerner Research Institute, Cleveland Clinic, OH 44195, USA.
Charlie AndrojnaEngineering Core, Lerner Research Institute, Cleveland Clinic, OH 44195, USA.
Kenneth B BakerDepartment of Neuroscience, Lerner Research Institute, Cleveland Clinic, OH 44195, USA.
Cleveland Clinic Lerner College of Medicine · USCleveland Clinic · US

Funding

Deep Brain Stimulation of the Cerebellar Dentate Nucleus to Enhance Chronic, Post-Traumatic Brain Injury RehabilitationR01NS116384 · NINDS · CLEVELAND CLINIC LERNER COM-CWRU · PI BAKER, KENNETH B, MACHADO, ANDRE GUELMAN · 2020 to 2024
$2.5M
Cerebellar deep brain stimulation to enhance chronic post-stroke rehabilitationR01NS105899 · NINDS · CLEVELAND CLINIC LERNER COM-CWRU · PI BAKER, KENNETH B, MACHADO, ANDRE GUELMAN · 2018 to 2022
$2.5M
NINDS NIH HHS R01 NS105899NINDS NIH HHS R01 NS116384
6 · The paper itself

Abstract

Functional neuroimaging methods like fMRI and PET are vital in neuroscience research, but require that subjects remain still throughout the scan. In animal research, anesthetic agents are typically applied to facilitate the acquisition of high-quality data with minimal motion artifact. However, anesthesia can have profound effects on brain metabolism, selectively altering dynamic neural networks and confounding the acquired data. To overcome the challenge, we have developed a novel head fixation device designed to support awake rat brain imaging. A validation experiment demonstrated that the device effectively minimizes animal motion throughout the scan, with mean absolute displacement and mean relative displacement of 0.0256 (SD: 0.001) and 0.009 (SD: 0.002), across eight evaluated subjects throughout fMRI image acquisition (total scanning time per subject: 31 min, 12 s). Furthermore, the awake scans did not induce discernable stress to the animals, with stable physiological parameters throughout the scan (Mean HR: 344, Mean RR: 56, Mean SpO

Indexed as

AnestheticsWakefulnessAnimalsBrainHeadHumansMagnetic Resonance ImagingNeuroimagingRatsAnestheticsAwake imagingFunctional imagingfunctional MRIHead fixation deviceRestrainer deviceSmall animal imaging

Identifiers

PMID38423263
PMCPMC10935597
OpenAlexW4392202577

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.